Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Weighty Genes: UDE-scientists find new genetic variants for obesity

26.04.2012
Obesity is influenced environmental and genetic factors. The genetic predisposition accounts for more than 50 percent of the variance in body weight. Roughly three dozen genes are known to have an influence on body weight regulation.
Together with international colleagues, a group of scientists of the University of Duisburg-Essen (UDE) has identified two new genetic loci for obesity. The results are part of a large international study.

Initially, the scientists analyzed early-onset obesity. Genetic data of 5,530 obese children and adolescents and 8,318 normal weight controls from 14 national studies – including study groups from Essen - were used. ”Subsequently it turned out that the identified genes also cause weight gain in adults” explained Dr Anke Hinney.
The molecular geneticist from the Department of Child and Adolescent Psychiatry, University of Duisburg-Essen is looking for genetic predispositions for obesity together with Prof Dr Johannes Hebebrand (Head of the Department) and Dr André Scherag of the Institute for Medical Informatics, Biometry and Epidemiology, University of Duisburg-Essen.

The newly identified variants have cumbersome names: One (‘rs9568856’) is located in the proximity of a gene called OLFM4, the other ‘rs9299’, is located near a gene called HOXB5. Their existence is far from being disadvantageous. Nature has been clever, says Anke Hinney, “The discovered genetic variants confer a clear advantage for survival during times of scarcity, because sparsely available calories can be used optimally.” Environmental conditions are also relevant. “One only gains a considerable amount of weight if further genetic variants are involved, as well as other factors like intake of highly caloric food and lack of exercise” demonstrates Dr André Scherag.

What benefit do obese people have from the fact that more and more genetic variants are being discovered? “We are hope to be able to improve therapy for overweight individuals by shedding light on underlying biological mechanisms”, claims Prof Dr Hebebrand who is also the coordinator of the obesity network that is funded by the Federal Ministry of Education and Research (BMBF).

The results of the investigation were published in the latest edition of the journal Nature Genetics (the Early Growth Genetics (EGG) Consortium et al., A genome-wide association meta-analysis identifies new childhood obesity loci. Nat Genet. 2012 Apr 8. doi: 10.1038/ng.2247. [Epub ahead of print])

For more information contact: Dr Anke Hinney,
f: 0201/959-7025, anke.hinney@uni-due.de

Editorial staff: Ulrike Bohnsack, f: 0203/379-2429

Beate Kostka | idw
Further information:
http://www.uni-due.de

More articles from Life Sciences:

nachricht Unique genome architectures after fertilisation in single-cell embryos
30.03.2017 | IMBA - Institut für Molekulare Biotechnologie der Österreichischen Akademie der Wissenschaften GmbH

nachricht Transport of molecular motors into cilia
28.03.2017 | Aarhus University

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A Challenging European Research Project to Develop New Tiny Microscopes

The Institute of Semiconductor Technology and the Institute of Physical and Theoretical Chemistry, both members of the Laboratory for Emerging Nanometrology (LENA), at Technische Universität Braunschweig are partners in a new European research project entitled ChipScope, which aims to develop a completely new and extremely small optical microscope capable of observing the interior of living cells in real time. A consortium of 7 partners from 5 countries will tackle this issue with very ambitious objectives during a four-year research program.

To demonstrate the usefulness of this new scientific tool, at the end of the project the developed chip-sized microscope will be used to observe in real-time...

Im Focus: Giant Magnetic Fields in the Universe

Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.

The results will be published on March 22 in the journal „Astronomy & Astrophysics“.

Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...

Im Focus: Tracing down linear ubiquitination

Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.

Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...

Im Focus: Perovskite edges can be tuned for optoelectronic performance

Layered 2D material improves efficiency for solar cells and LEDs

In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...

Im Focus: Polymer-coated silicon nanosheets as alternative to graphene: A perfect team for nanoelectronics

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

International Land Use Symposium ILUS 2017: Call for Abstracts and Registration open

20.03.2017 | Event News

CONNECT 2017: International congress on connective tissue

14.03.2017 | Event News

ICTM Conference: Turbine Construction between Big Data and Additive Manufacturing

07.03.2017 | Event News

 
Latest News

'On-off switch' brings researchers a step closer to potential HIV vaccine

30.03.2017 | Health and Medicine

Penn studies find promise for innovations in liquid biopsies

30.03.2017 | Health and Medicine

An LED-based device for imaging radiation induced skin damage

30.03.2017 | Medical Engineering

VideoLinks
B2B-VideoLinks
More VideoLinks >>>