Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Weighty Genes: UDE-scientists find new genetic variants for obesity

26.04.2012
Obesity is influenced environmental and genetic factors. The genetic predisposition accounts for more than 50 percent of the variance in body weight. Roughly three dozen genes are known to have an influence on body weight regulation.
Together with international colleagues, a group of scientists of the University of Duisburg-Essen (UDE) has identified two new genetic loci for obesity. The results are part of a large international study.

Initially, the scientists analyzed early-onset obesity. Genetic data of 5,530 obese children and adolescents and 8,318 normal weight controls from 14 national studies – including study groups from Essen - were used. ”Subsequently it turned out that the identified genes also cause weight gain in adults” explained Dr Anke Hinney.
The molecular geneticist from the Department of Child and Adolescent Psychiatry, University of Duisburg-Essen is looking for genetic predispositions for obesity together with Prof Dr Johannes Hebebrand (Head of the Department) and Dr André Scherag of the Institute for Medical Informatics, Biometry and Epidemiology, University of Duisburg-Essen.

The newly identified variants have cumbersome names: One (‘rs9568856’) is located in the proximity of a gene called OLFM4, the other ‘rs9299’, is located near a gene called HOXB5. Their existence is far from being disadvantageous. Nature has been clever, says Anke Hinney, “The discovered genetic variants confer a clear advantage for survival during times of scarcity, because sparsely available calories can be used optimally.” Environmental conditions are also relevant. “One only gains a considerable amount of weight if further genetic variants are involved, as well as other factors like intake of highly caloric food and lack of exercise” demonstrates Dr André Scherag.

What benefit do obese people have from the fact that more and more genetic variants are being discovered? “We are hope to be able to improve therapy for overweight individuals by shedding light on underlying biological mechanisms”, claims Prof Dr Hebebrand who is also the coordinator of the obesity network that is funded by the Federal Ministry of Education and Research (BMBF).

The results of the investigation were published in the latest edition of the journal Nature Genetics (the Early Growth Genetics (EGG) Consortium et al., A genome-wide association meta-analysis identifies new childhood obesity loci. Nat Genet. 2012 Apr 8. doi: 10.1038/ng.2247. [Epub ahead of print])

For more information contact: Dr Anke Hinney,
f: 0201/959-7025, anke.hinney@uni-due.de

Editorial staff: Ulrike Bohnsack, f: 0203/379-2429

Beate Kostka | idw
Further information:
http://www.uni-due.de

More articles from Life Sciences:

nachricht At last, butterflies get a bigger, better evolutionary tree
16.02.2018 | Florida Museum of Natural History

nachricht New treatment strategies for chronic kidney disease from the animal kingdom
16.02.2018 | Veterinärmedizinische Universität Wien

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Demonstration of a single molecule piezoelectric effect

Breakthrough provides a new concept of the design of molecular motors, sensors and electricity generators at nanoscale

Researchers from the Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague), Institute of Physics of the CAS (IP CAS) and Palacký University...

Im Focus: Hybrid optics bring color imaging using ultrathin metalenses into focus

For photographers and scientists, lenses are lifesavers. They reflect and refract light, making possible the imaging systems that drive discovery through the microscope and preserve history through cameras.

But today's glass-based lenses are bulky and resist miniaturization. Next-generation technologies, such as ultrathin cameras or tiny microscopes, require...

Im Focus: Stem cell divisions in the adult brain seen for the first time

Scientists from the University of Zurich have succeeded for the first time in tracking individual stem cells and their neuronal progeny over months within the intact adult brain. This study sheds light on how new neurons are produced throughout life.

The generation of new nerve cells was once thought to taper off at the end of embryonic development. However, recent research has shown that the adult brain...

Im Focus: Interference as a new method for cooling quantum devices

Theoretical physicists propose to use negative interference to control heat flow in quantum devices. Study published in Physical Review Letters

Quantum computer parts are sensitive and need to be cooled to very low temperatures. Their tiny size makes them particularly susceptible to a temperature...

Im Focus: Autonomous 3D scanner supports individual manufacturing processes

Let’s say the armrest is broken in your vintage car. As things stand, you would need a lot of luck and persistence to find the right spare part. But in the world of Industrie 4.0 and production with batch sizes of one, you can simply scan the armrest and print it out. This is made possible by the first ever 3D scanner capable of working autonomously and in real time. The autonomous scanning system will be on display at the Hannover Messe Preview on February 6 and at the Hannover Messe proper from April 23 to 27, 2018 (Hall 6, Booth A30).

Part of the charm of vintage cars is that they stopped making them long ago, so it is special when you do see one out on the roads. If something breaks or...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

2nd International Conference on High Temperature Shape Memory Alloys (HTSMAs)

15.02.2018 | Event News

Aachen DC Grid Summit 2018

13.02.2018 | Event News

How Global Climate Policy Can Learn from the Energy Transition

12.02.2018 | Event News

 
Latest News

Fingerprints of quantum entanglement

16.02.2018 | Information Technology

'Living bandages': NUST MISIS scientists develop biocompatible anti-burn nanofibers

16.02.2018 | Health and Medicine

Hubble sees Neptune's mysterious shrinking storm

16.02.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>