Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Take Your Vitamins!

18.03.2011
Tocopherol Derivatives as New Dioxin Receptor Antagonists

When reactive oxygen species (ROS) hit the body, vitamin E helps to prevent damage to tissues and cells by acting as an antioxidant. The health benefits of vitamin E are numerous, and in fact, studies have found that people with higher levels of vitamin E in their system have a lower risk of heart disease and certain forms of cancer.

A team led by Thomas Rosenau from the University of Natural Resources and Life Sciences in Vienna (Austria) now describe their synthesis of a series of modified vitamin E derivatives that show promise as dioxin receptor antagonists in the European Journal of Organic Chemistry.

Chemically, vitamin E is composed of several compounds from the tocopherol and tocotrienol family. The search for novel tocopherol derivatives that possess altered properties, including different lipophilicity or oxidative lability, while still maintaining the physiological benefits of the vitamin is now an important field of study. In this vein, the aryl hydrocarbon receptor (AhR), also called dioxin receptor, is present in most cells and tissue types of the body. AhR is typically inactive, but upon exposure to environmental pollutants, carcinogens, and drugs, for instance, it can form a complex that may be harmful to the body. Several aromatic, fat-soluble derivatives have been identified as key compounds that bind to AhR, and a correlation between their binding and their toxic nature has been documented.

Fluorine-containing aromatic compounds have been shown to be strong AhR antagonists in that they preclude the negative health effects associated with exposure to toxic substances. The Austrian research team reasoned that substitution of the planar aromatic ring of tocopherol compounds with a fluorinated aromatic moiety in combination with their inherent antioxidative and lipophilic properties would produce very suitable ligands for the AhR target. Thus, a small library of substituted tocopherols carrying mono- or difluorinated aromatic substituents was prepared. The authors showed that their compounds were very potent AhR antagonists in vitro, and in fact, their compounds were two to three orders of magnitude more effective than previously known antagonists and comparably as effective as some of the strongest antagonists hitherto known. Thus, patients may someday be able to turn to this new family of vitamin E derivatives as a preventative measure against the onslaught of diseases and illnesses after exposure to dangerous materials.

Author: Thomas Rosenau, University of Natural Resources and Life Sciences (Vienna), http://www.chemie.boku.ac.at/16054.html

Title: Synthesis of 5-(Fluorophenyl)tocopherols as Novel Dioxin Receptor Antagonists

European Journal of Organic Chemistry, Permalink to the article: http://dx.doi.org/10.1002/ejoc.201100178

Thomas Rosenau | Wiley-VCH
Further information:
http://www.chemie.boku.ac.at/16054.html
http://dx.doi.org/10.1002/ejoc.201100178
http://www.wiley-vch.de

More articles from Life Sciences:

nachricht Warming ponds could accelerate climate change
21.02.2017 | University of Exeter

nachricht An alternative to opioids? Compound from marine snail is potent pain reliever
21.02.2017 | University of Utah

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

Im Focus: Mimicking nature's cellular architectures via 3-D printing

Research offers new level of control over the structure of 3-D printed materials

Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...

Im Focus: Three Magnetic States for Each Hole

Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".

Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

Impacts of mass coral die-off on Indian Ocean reefs revealed

21.02.2017 | Earth Sciences

Novel breast tomosynthesis technique reduces screening recall rate

21.02.2017 | Medical Engineering

Use your Voice – and Smart Homes will “LISTEN”

21.02.2017 | Trade Fair News

VideoLinks
B2B-VideoLinks
More VideoLinks >>>