"There are two fairly obvious potential directions that could exploit this kind of research," says Graham Hatfull of the University of Pittsburgh, an author of the study. "The first is the possibility of using the phages directly as a therapy for acne. The second is the opportunity to use phage-derived components for their activities."
P. acnes is a normal resident on human skin, but its numbers increase substantially at puberty, eliciting an inflammatory response that can lead to acne. Although antibiotics can be effective in treating acne, antibiotic-resistant strains of P. acnes have emerged, highlighting the need for better therapies.
Hatfull and his colleagues at the University of Pittsburgh along with scientists from the University of California, Los Angeles, isolated phages and P. acnes bacteria from human volunteers with and without acne, then sequenced the phages' genomes. What they found in those genomes was surprising. The phages were all remarkably similar, sharing more than 85% of their DNA, an unheard of level of similarity among viruses, which usually exhibit a great deal of diversity. This lack of genetic diversity suggests that resistance to phage-based antimicrobial therapy is less likely to develop, they say.
All of the phages carry a gene that makes a protein called endolysin, an enzyme that is thought to break down bacterial cell walls and kill the bacteria. Enzymes like this are used in other applications, says Hatfull, suggesting that endolysin from these phages might also be useful as a topical anti-acne therapeutic. "This work has given us very useful information about the diversity of that set of enzymes and helps pave the way for thinking about potential applications," he says.
From here, Hatfull says, research with these phages will explore how they might be used therapeutically, but phages like these can also provide useful tools, like genes and enzymes, that can be used to manipulate and understand the bacteria they infect. "The information derived from these phages helps contribute toward those kinds of genetic tools," says Hatfull.
mBio® is an open access online journal published by the American Society for Microbiology to make microbiology research broadly accessible. The focus of the journal is on rapid publication of cutting-edge research spanning the entire spectrum of microbiology and related fields. It can be found online at http://mBio.asm.org.
The American Society for Microbiology is the largest single life science society, composed of over 39,000 scientists and health professionals. ASM's mission is to advance the microbiological sciences as a vehicle for understanding life processes and to apply and communicate this knowledge for the improvement of health and environmental and economic well-being worldwide.
Jim Sliwa | EurekAlert!
Cryo-electron microscopy achieves unprecedented resolution using new computational methods
24.03.2017 | DOE/Lawrence Berkeley National Laboratory
How cheetahs stay fit and healthy
24.03.2017 | Forschungsverbund Berlin e.V.
Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.
The results will be published on March 22 in the journal „Astronomy & Astrophysics“.
Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...
Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...
In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...
20.03.2017 | Event News
14.03.2017 | Event News
07.03.2017 | Event News
24.03.2017 | Materials Sciences
24.03.2017 | Physics and Astronomy
24.03.2017 | Physics and Astronomy