A Europe-wide network of labs focusing on RNA research is needed to make the most of RNA's high potential for treating a wide range of diseases. The recommendation for this virtual research institute comes from a panel of biologists at the European Science Foundation in a report published today, 'RNA World: a new frontier in biomedical research'.
Ten years on from the human genome project, RNA (ribonucleic acid) has stolen some of DNA's limelight. The basic ingredient of our genes, DNA long outshone the other form of genetic material in our cells, RNA. RNA was seen as a simple stepping stone in the cell's gene-reading activities.
Research over the last decade has shown RNA to be a remarkable molecule and a multi-talented actor in heredity. It is thought to be a major participant in the chemical reactions that led to the origins of life on Earth - the 'RNA World' hypothesis. RNA also controls genes in a way that was only recently discovered: a process called RNA interference, or RNAi. Medical researchers are currently testing new types of RNAi-based drugs for treating conditions such as macular degeneration, the leading cause of blindness, and various infections, including those caused by HIV and the herpes virus.
"RNA could bring significant advances to the diagnosis, treatment and prevention of many human diseases," said Professor Jörg Vogel from the University of Würzburg, Germany, who co-chaired the report. "In the global context, it's surprising that Europe doesn't have many centres specifically funded for and dedicated to it, particularly in comparison to the US. We strongly recommend creating a network of RNA centres, linked together as a Europe-wide 'virtual institute'. A first step could involve calls through the European Commission and national funders. "
The virtual RNA institute would be made up of locally-funded, multidisciplinary centres with a critical mass of strong research groups in disciplines such as biology, biochemistry, chemistry, genetics, bioinformatics, biophysics, structural analysis, microbiology, plant sciences and clinical medicine. This environment could be well-suited to promoting superior training of a generation of young scientists, PhD students and postdoctoral researchers. They could also help deliver dedicated education programmes for RNA research, which are currently lacking.
A particular area where an increasing demand in the future can be foreseen is, as in almost all other areas of life science, bioinformatics. "A new generation of bioinformaticians needs to be trained to meet future demand, in RNA research and in many other areas of the life sciences," continues Professor Vogel.
New models for public funding of infrastructure and resources for promising compounds to be used in the clinic should be developed. The financial burden for taking basic compounds and developing them into drugs could be shared by academic-industrial partnerships.
'RNA World: a new frontier in biomedical research' reviews the high pace of discovery in RNA research and gives a 5-10 year outlook of how both basic RNA research and its use in clinical practice should develop. Nine thematic priority areas were identified to address new and promising opportunities for biomedical, biotechnological, pharmaceutical and clinical RNA research.
For more information about the thematic areas and detailed recommendations, the Forward Look 'RNA World: a new frontier in biomedical research' is available online: www.esf.org/publications/
Chloe Kembery | EurekAlert!
Single-stranded DNA and RNA origami go live
15.12.2017 | Wyss Institute for Biologically Inspired Engineering at Harvard
New antbird species discovered in Peru by LSU ornithologists
15.12.2017 | Louisiana State University
DNA molecules that follow specific instructions could offer more precise molecular control of synthetic chemical systems, a discovery that opens the door for engineers to create molecular machines with new and complex behaviors.
Researchers have created chemical amplifiers and a chemical oscillator using a systematic method that has the potential to embed sophisticated circuit...
MPQ scientists achieve long storage times for photonic quantum bits which break the lower bound for direct teleportation in a global quantum network.
Concerning the development of quantum memories for the realization of global quantum networks, scientists of the Quantum Dynamics Division led by Professor...
Researchers have developed a water cloaking concept based on electromagnetic forces that could eliminate an object's wake, greatly reducing its drag while...
Tiny pores at a cell's entryway act as miniature bouncers, letting in some electrically charged atoms--ions--but blocking others. Operating as exquisitely sensitive filters, these "ion channels" play a critical role in biological functions such as muscle contraction and the firing of brain cells.
To rapidly transport the right ions through the cell membrane, the tiny channels rely on a complex interplay between the ions and surrounding molecules,...
The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecule’s storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters.
Over the past few years, the building blocks of storage media have gotten ever smaller. But further miniaturization of the current technology is hindered by...
11.12.2017 | Event News
08.12.2017 | Event News
07.12.2017 | Event News
15.12.2017 | Power and Electrical Engineering
15.12.2017 | Materials Sciences
15.12.2017 | Life Sciences