Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Vaccine With No Jab

01.04.2010
Protein vaccines for needle-free immunization through the skin

Most immunizations currently involve an injection in the arm. In the future, vaccination may be accomplished without the unpleasant jab of a needle: a team led by Victor C. Yang at the University of Michigan (USA) has developed a method by which vaccines can pass directly through the skin without a needle.

As the researchers report in the journal Angewandte Chemie, merely linking a special short peptide molecule to the vaccine, which can then be administered in the form of a patch, will do the job.

Vaccines usually consist of proteins, and only a few can be administered orally whilst most must be injected directly into a muscle. Therefore, skin is an attractive target for non-invasive vaccination. However, protein vaccines cannot pass through our skin, especially through its impermeable corneal layer. There are a few protein drugs that can currently be applied through the skin, but their production remains complex and expensive. They must be wrapped in special “transporters,” such as liposomes, that can pass through the skin.

The goal of Yang and co-workers is to find proteins that can do the job without the packaging. Thus, his team has developed a short peptide, the low molecular weight protamine (LMWP) that is able to pass through cell membranes into the interior of cells. LMWP peptides can be produced quickly, easily, and inexpensively in large amounts from the protein protamine. Protamine is a pharmaceutical agent, given to treat hemorrhages that occur after treatment with heparin or elevated levels of heparin caused by disease.

When LMWP is linked to a protein, it simply carries this “freight” along through the membrane into the interior of the cell. In this way, LMWP is also able to pass attached proteins through the corneal layer. The researchers were able to demonstrate this with various test proteins, linked to the LMPW, that were also labeled with a fluorescence dye. Particular accumulation of the proteins was observed in the epidermis. Activation of the immune system in mice was observed that was equivalent to that elicited by conventional immunization.

Our skin is not just our primary protection against infections because it presents a physical barrier; our epidermis is also rich in Langerhans cells, which participate in triggering an immune response. Therefore, it may be favorable for an immunization if the vaccine accumulates in the epidermis. One particularly interesting aspect of this new non-invasive method is that the “boosters” required for many vaccination protocols could be administered by the patients themselves. This could increase the success of vaccination campaigns in poor and remote regions of the world, where medical facilities are scarce.

Author: Victor C. Yang, University of Michigan, Ann Arbor (USA), http://pharmacy.umich.edu/pharmacy/victor%20chi-min%20yang

Title: Synthetic Skin-Permeable Proteins Enabling Needleless Immunization

Angewandte Chemie International Edition 2010, 49, No. 15, 2724–2727, Permalink to the article: http://dx.doi.org/10.1002/anie.200906153

Victor C. Yang | Angewandte Chemie
Further information:
http://pressroom.angewandte.org
http://pharmacy.umich.edu/pharmacy/victor%20chi-min%20yang

More articles from Life Sciences:

nachricht Molecular Force Sensors
20.09.2017 | Max-Planck-Institut für Biochemie

nachricht Foster tadpoles trigger parental instinct in poison frogs
20.09.2017 | Veterinärmedizinische Universität Wien

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Tiny lasers from a gallery of whispers

New technique promises tunable laser devices

Whispering gallery mode (WGM) resonators are used to make tiny micro-lasers, sensors, switches, routers and other devices. These tiny structures rely on a...

Im Focus: Ultrafast snapshots of relaxing electrons in solids

Using ultrafast flashes of laser and x-ray radiation, scientists at the Max Planck Institute of Quantum Optics (Garching, Germany) took snapshots of the briefest electron motion inside a solid material to date. The electron motion lasted only 750 billionths of the billionth of a second before it fainted, setting a new record of human capability to capture ultrafast processes inside solids!

When x-rays shine onto solid materials or large molecules, an electron is pushed away from its original place near the nucleus of the atom, leaving a hole...

Im Focus: Quantum Sensors Decipher Magnetic Ordering in a New Semiconducting Material

For the first time, physicists have successfully imaged spiral magnetic ordering in a multiferroic material. These materials are considered highly promising candidates for future data storage media. The researchers were able to prove their findings using unique quantum sensors that were developed at Basel University and that can analyze electromagnetic fields on the nanometer scale. The results – obtained by scientists from the University of Basel’s Department of Physics, the Swiss Nanoscience Institute, the University of Montpellier and several laboratories from University Paris-Saclay – were recently published in the journal Nature.

Multiferroics are materials that simultaneously react to electric and magnetic fields. These two properties are rarely found together, and their combined...

Im Focus: Fast, convenient & standardized: New lab innovation for automated tissue engineering & drug

MBM ScienceBridge GmbH successfully negotiated a license agreement between University Medical Center Göttingen (UMG) and the biotech company Tissue Systems Holding GmbH about commercial use of a multi-well tissue plate for automated and reliable tissue engineering & drug testing.

MBM ScienceBridge GmbH successfully negotiated a license agreement between University Medical Center Göttingen (UMG) and the biotech company Tissue Systems...

Im Focus: Silencing bacteria

HZI researchers pave the way for new agents that render hospital pathogens mute

Pathogenic bacteria are becoming resistant to common antibiotics to an ever increasing degree. One of the most difficult germs is Pseudomonas aeruginosa, a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

“Lasers in Composites Symposium” in Aachen – from Science to Application

19.09.2017 | Event News

I-ESA 2018 – Call for Papers

12.09.2017 | Event News

EMBO at Basel Life, a new conference on current and emerging life science research

06.09.2017 | Event News

 
Latest News

Molecular Force Sensors

20.09.2017 | Life Sciences

Producing electricity during flight

20.09.2017 | Power and Electrical Engineering

Tiny lasers from a gallery of whispers

20.09.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>