Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Vaccine With No Jab

01.04.2010
Protein vaccines for needle-free immunization through the skin

Most immunizations currently involve an injection in the arm. In the future, vaccination may be accomplished without the unpleasant jab of a needle: a team led by Victor C. Yang at the University of Michigan (USA) has developed a method by which vaccines can pass directly through the skin without a needle.

As the researchers report in the journal Angewandte Chemie, merely linking a special short peptide molecule to the vaccine, which can then be administered in the form of a patch, will do the job.

Vaccines usually consist of proteins, and only a few can be administered orally whilst most must be injected directly into a muscle. Therefore, skin is an attractive target for non-invasive vaccination. However, protein vaccines cannot pass through our skin, especially through its impermeable corneal layer. There are a few protein drugs that can currently be applied through the skin, but their production remains complex and expensive. They must be wrapped in special “transporters,” such as liposomes, that can pass through the skin.

The goal of Yang and co-workers is to find proteins that can do the job without the packaging. Thus, his team has developed a short peptide, the low molecular weight protamine (LMWP) that is able to pass through cell membranes into the interior of cells. LMWP peptides can be produced quickly, easily, and inexpensively in large amounts from the protein protamine. Protamine is a pharmaceutical agent, given to treat hemorrhages that occur after treatment with heparin or elevated levels of heparin caused by disease.

When LMWP is linked to a protein, it simply carries this “freight” along through the membrane into the interior of the cell. In this way, LMWP is also able to pass attached proteins through the corneal layer. The researchers were able to demonstrate this with various test proteins, linked to the LMPW, that were also labeled with a fluorescence dye. Particular accumulation of the proteins was observed in the epidermis. Activation of the immune system in mice was observed that was equivalent to that elicited by conventional immunization.

Our skin is not just our primary protection against infections because it presents a physical barrier; our epidermis is also rich in Langerhans cells, which participate in triggering an immune response. Therefore, it may be favorable for an immunization if the vaccine accumulates in the epidermis. One particularly interesting aspect of this new non-invasive method is that the “boosters” required for many vaccination protocols could be administered by the patients themselves. This could increase the success of vaccination campaigns in poor and remote regions of the world, where medical facilities are scarce.

Author: Victor C. Yang, University of Michigan, Ann Arbor (USA), http://pharmacy.umich.edu/pharmacy/victor%20chi-min%20yang

Title: Synthetic Skin-Permeable Proteins Enabling Needleless Immunization

Angewandte Chemie International Edition 2010, 49, No. 15, 2724–2727, Permalink to the article: http://dx.doi.org/10.1002/anie.200906153

Victor C. Yang | Angewandte Chemie
Further information:
http://pressroom.angewandte.org
http://pharmacy.umich.edu/pharmacy/victor%20chi-min%20yang

More articles from Life Sciences:

nachricht Cancer diagnosis: no more needles?
25.05.2018 | Christian-Albrechts-Universität zu Kiel

nachricht Less is more? Gene switch for healthy aging found
25.05.2018 | Leibniz-Institut für Alternsforschung - Fritz-Lipmann-Institut e.V. (FLI)

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Powerful IT security for the car of the future – research alliance develops new approaches

The more electronics steer, accelerate and brake cars, the more important it is to protect them against cyber-attacks. That is why 15 partners from industry and academia will work together over the next three years on new approaches to IT security in self-driving cars. The joint project goes by the name Security For Connected, Autonomous Cars (SecForCARs) and has funding of €7.2 million from the German Federal Ministry of Education and Research. Infineon is leading the project.

Vehicles already offer diverse communication interfaces and more and more automated functions, such as distance and lane-keeping assist systems. At the same...

Im Focus: Molecular switch will facilitate the development of pioneering electro-optical devices

A research team led by physicists at the Technical University of Munich (TUM) has developed molecular nanoswitches that can be toggled between two structurally different states using an applied voltage. They can serve as the basis for a pioneering class of devices that could replace silicon-based components with organic molecules.

The development of new electronic technologies drives the incessant reduction of functional component sizes. In the context of an international collaborative...

Im Focus: LZH showcases laser material processing of tomorrow at the LASYS 2018

At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.

At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...

Im Focus: Self-illuminating pixels for a new display generation

There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?

At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...

Im Focus: Explanation for puzzling quantum oscillations has been found

So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics

Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

In focus: Climate adapted plants

25.05.2018 | Event News

Save the date: Forum European Neuroscience – 07-11 July 2018 in Berlin, Germany

02.05.2018 | Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

 
Latest News

In focus: Climate adapted plants

25.05.2018 | Event News

Flow probes from the 3D printer

25.05.2018 | Machine Engineering

Less is more? Gene switch for healthy aging found

25.05.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>