New, groundbreaking research by University of Victoria biomedical engineer Stephanie Willerth has significantly advanced the understanding of HIV and how to treat it.
“The virus mutates at a very high rate which is very problematic for HIV patients because the virus eventually develops resistance to medications,’’ explains Willerth, a faculty member with UVic’s Department of Mechanical Engineering and the Division of Medical Sciences.
Willerth and her team studied approximately 15,000 different versions of the virus—something that has never been done before. This information has allowed them to locate the specific genes of the virus that were resistant to the drugs—knowledge that could ultimately help researchers develop more effective treatments for HIV.
Willerth says that the methods she used can be applied to other difficult-to-treat viruses such as swine flu, Ebola, influenza or even staph infections.
“To study all of these different versions we have to replicate them millions of times, especially when it comes to complex viruses like HIV,” explains Willerth. “Because this research method requires a large amount of genetic material and there are obvious risks of duplicating highly contagious viruses, scientists have avoided doing this. Our research was unique because of the method we used—we isolated the genetic material from HIV, so that it was no longer alive, before we replicated it.”
After replicating the virus from a small sample obtained from a long-term HIV patient who had developed drug resistance to their treatment, Willerth and her team studied its genetic make-up using “next generation” DNA sequencing—a new method that allows researchers to study millions of molecules at a time.
Willerth conducted this post-doctorate research at the University of California Berkeley Lab. Her research findings are available at http://bit.ly/hD7KuO
Media contacts:Stephanie Willerth (Mechanical Engineering) at email@example.com or 250-721-7303
Valerie Shore | EurekAlert!
Gene therapy shows promise for treating Niemann-Pick disease type C1
27.10.2016 | NIH/National Human Genome Research Institute
'Neighbor maps' reveal the genome's 3-D shape
27.10.2016 | International School of Advanced Studies (SISSA)
Ultrafast lasers have introduced new possibilities in engraving ultrafine structures, and scientists are now also investigating how to use them to etch microstructures into thin glass. There are possible applications in analytics (lab on a chip) and especially in electronics and the consumer sector, where great interest has been shown.
This new method was born of a surprising phenomenon: irradiating glass in a particular way with an ultrafast laser has the effect of making the glass up to a...
Terahertz excitation of selected crystal vibrations leads to an effective magnetic field that drives coherent spin motion
Controlling functional properties by light is one of the grand goals in modern condensed matter physics and materials science. A new study now demonstrates how...
Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.
"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...
In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.
A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...
By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.
"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...
14.10.2016 | Event News
14.10.2016 | Event News
12.10.2016 | Event News
27.10.2016 | Materials Sciences
27.10.2016 | Physics and Astronomy
27.10.2016 | Life Sciences