New, groundbreaking research by University of Victoria biomedical engineer Stephanie Willerth has significantly advanced the understanding of HIV and how to treat it.
“The virus mutates at a very high rate which is very problematic for HIV patients because the virus eventually develops resistance to medications,’’ explains Willerth, a faculty member with UVic’s Department of Mechanical Engineering and the Division of Medical Sciences.
Willerth and her team studied approximately 15,000 different versions of the virus—something that has never been done before. This information has allowed them to locate the specific genes of the virus that were resistant to the drugs—knowledge that could ultimately help researchers develop more effective treatments for HIV.
Willerth says that the methods she used can be applied to other difficult-to-treat viruses such as swine flu, Ebola, influenza or even staph infections.
“To study all of these different versions we have to replicate them millions of times, especially when it comes to complex viruses like HIV,” explains Willerth. “Because this research method requires a large amount of genetic material and there are obvious risks of duplicating highly contagious viruses, scientists have avoided doing this. Our research was unique because of the method we used—we isolated the genetic material from HIV, so that it was no longer alive, before we replicated it.”
After replicating the virus from a small sample obtained from a long-term HIV patient who had developed drug resistance to their treatment, Willerth and her team studied its genetic make-up using “next generation” DNA sequencing—a new method that allows researchers to study millions of molecules at a time.
Willerth conducted this post-doctorate research at the University of California Berkeley Lab. Her research findings are available at http://bit.ly/hD7KuO
Media contacts:Stephanie Willerth (Mechanical Engineering) at email@example.com or 250-721-7303
Valerie Shore | EurekAlert!
Water forms 'spine of hydration' around DNA, group finds
26.05.2017 | Cornell University
How herpesviruses win the footrace against the immune system
26.05.2017 | Helmholtz-Zentrum für Infektionsforschung
Staphylococcus aureus is a feared pathogen (MRSA, multi-resistant S. aureus) due to frequent resistances against many antibiotics, especially in hospital infections. Researchers at the Paul-Ehrlich-Institut have identified immunological processes that prevent a successful immune response directed against the pathogenic agent. The delivery of bacterial proteins with RNA adjuvant or messenger RNA (mRNA) into immune cells allows the re-direction of the immune response towards an active defense against S. aureus. This could be of significant importance for the development of an effective vaccine. PLOS Pathogens has published these research results online on 25 May 2017.
Staphylococcus aureus (S. aureus) is a bacterium that colonizes by far more than half of the skin and the mucosa of adults, usually without causing infections....
Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.
The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....
An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.
We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...
Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.
Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...
An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...
24.05.2017 | Event News
23.05.2017 | Event News
22.05.2017 | Event News
26.05.2017 | Life Sciences
26.05.2017 | Life Sciences
26.05.2017 | Physics and Astronomy