New, groundbreaking research by University of Victoria biomedical engineer Stephanie Willerth has significantly advanced the understanding of HIV and how to treat it.
“The virus mutates at a very high rate which is very problematic for HIV patients because the virus eventually develops resistance to medications,’’ explains Willerth, a faculty member with UVic’s Department of Mechanical Engineering and the Division of Medical Sciences.
Willerth and her team studied approximately 15,000 different versions of the virus—something that has never been done before. This information has allowed them to locate the specific genes of the virus that were resistant to the drugs—knowledge that could ultimately help researchers develop more effective treatments for HIV.
Willerth says that the methods she used can be applied to other difficult-to-treat viruses such as swine flu, Ebola, influenza or even staph infections.
“To study all of these different versions we have to replicate them millions of times, especially when it comes to complex viruses like HIV,” explains Willerth. “Because this research method requires a large amount of genetic material and there are obvious risks of duplicating highly contagious viruses, scientists have avoided doing this. Our research was unique because of the method we used—we isolated the genetic material from HIV, so that it was no longer alive, before we replicated it.”
After replicating the virus from a small sample obtained from a long-term HIV patient who had developed drug resistance to their treatment, Willerth and her team studied its genetic make-up using “next generation” DNA sequencing—a new method that allows researchers to study millions of molecules at a time.
Willerth conducted this post-doctorate research at the University of California Berkeley Lab. Her research findings are available at http://bit.ly/hD7KuO
Media contacts:Stephanie Willerth (Mechanical Engineering) at email@example.com or 250-721-7303
Valerie Shore | EurekAlert!
Biologists unravel another mystery of what makes DNA go 'loopy'
16.03.2018 | Emory Health Sciences
Scientists map the portal to the cell's nucleus
16.03.2018 | Rockefeller University
Animal photoreceptors capture light with photopigments. Researchers from the University of Göttingen have now discovered that these photopigments fulfill an...
On 15 March, the AWI research aeroplane Polar 5 will depart for Greenland. Concentrating on the furthest northeast region of the island, an international team...
The world’s second-largest ice shelf was the destination for a Polarstern expedition that ended in Punta Arenas, Chile on 14th March 2018. Oceanographers from...
At the 2018 ILA Berlin Air Show from April 25–29, the Fraunhofer Institute for Laser Technology ILT is showcasing extreme high-speed Laser Material Deposition (EHLA): A video documents how for metal components that are highly loaded, EHLA has already proved itself as an alternative to hard chrome plating, which is now allowed only under special conditions.
When the EU restricted the use of hexavalent chromium compounds to special applications requiring authorization, the move prompted a rethink in the surface...
At the ILA Berlin, hall 4, booth 202, Fraunhofer FHR will present two radar sensors for navigation support of drones. The sensors are valuable components in the implementation of autonomous flying drones: they function as obstacle detectors to prevent collisions. Radar sensors also operate reliably in restricted visibility, e.g. in foggy or dusty conditions. Due to their ability to measure distances with high precision, the radar sensors can also be used as altimeters when other sources of information such as barometers or GPS are not available or cannot operate optimally.
Drones play an increasingly important role in the area of logistics and services. Well-known logistic companies place great hope in these compact, aerial...
16.03.2018 | Event News
13.03.2018 | Event News
08.03.2018 | Event News
16.03.2018 | Earth Sciences
16.03.2018 | Physics and Astronomy
16.03.2018 | Life Sciences