This is the first time that the uterus has been identified as an endocrine organ, said University of Illinois veterinary biosciences professor Indrani Bagchi, who led the study with doctoral student Amrita Das. Their findings appear this week in the Proceedings of the National Academy of Science.
“It’s the local estrogen that’s critical in maintaining the growth of blood vessels within the uterus,” Das said. After an embryo implants, the researchers found, this locally produced estrogen acts in concert with progesterone secreted from the ovaries to spur the differentiation of uterine stromal cells, a process called decidualization, and promotes the growth of blood vessels that support the development of the embryo.
The researchers discovered that during decidualization, mouse uterine stromal cells increase their expression of P450 aromatase, a key enzyme that acts with other enzymes to convert androgens to estrogen.
Even in pregnant mice that have had their ovaries removed, the production of uterine estrogen is able to support the growth and differentiation of the tissue and blood vessels needed to sustain the pregnancy.
Progesterone supplementation is required, however, indicating that local estrogen alone is not sufficient to maintain pregnancy.
Blocking the activity of the aromatase with an inhibitor also blocked decidualization, the researchers found, another indication that a successful pregnancy relies on estrogen production in uterine cells.
There are advantages to producing the appropriate amount of estrogen right where it is needed, rather than relying on the ovaries, Bagchi said.
“During pregnancy, the ovaries would need to secrete a high level of estrogen to ensure that the right amount of estrogen is present in the uterus to support decidualization,” she said. “You can imagine that if the estrogen level goes high systemically, it could have a deleterious effect on pregnancy itself by antagonizing the progesterone action.”
The findings may also be helpful to the study of endometriosis, said molecular and integrative physiology professor Milan Bagchi, an author on the study. This disorder involves the growth of endometrial tissue, which is normally shed during menstruation, at sites outside the uterus, such as the peritoneal cavity and ovaries, producing painful lesions. Endometriosis is spurred, in part, by unusually high levels of estrogen secreted from endometrial tissue growing at these extrauterine sites, he said.Except during pregnancy, “a normal cycling uterus does not make estrogen,” he said. High estrogen levels block the activity of progesterone and can cause the
non-cancerous growth of tissue seen in endometriosis.
This study was supported by the National Institutes of Health (NIH) and by the Eunice Kennedy Shriver National Institute of Child Health and Human Development at the NIH as part of the Specialized Cooperative Centers Program in Reproduction and Infertility Research.
Diana Yates | University of Illinois
Scientists unlock ability to generate new sensory hair cells
22.02.2017 | Brigham and Women's Hospital
New insights into the information processing of motor neurons
22.02.2017 | Max Planck Florida Institute for Neuroscience
Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...
The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.
The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...
Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...
Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".
Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...
13.02.2017 | Event News
10.02.2017 | Event News
09.02.2017 | Event News
22.02.2017 | Power and Electrical Engineering
22.02.2017 | Life Sciences
22.02.2017 | Physics and Astronomy