Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

UO-Berkeley Lab unveil new nano-sized synthetic scaffolding technique

03.09.2014

Oil-and-water approach from Richmond's UO lab to spark new line of versatile peptoid nanosheets

Scientists, including University of Oregon chemist Geraldine Richmond, have tapped oil and water to create scaffolds of self-assembling, synthetic proteins called peptoid nanosheets that mimic complex biological mechanisms and processes.

The accomplishment -- detailed this week in a paper placed online ahead of print by the Proceedings of the National Academy of Sciences -- is expected to fuel an alternative design of the two-dimensional peptoid nanosheets that can be used in a broad range of applications. Among them could be improved chemical sensors and separators, and safer, more effective drug-delivery vehicles.

Study co-author Ronald Zuckermann of the Molecular Foundry at Lawrence Berkeley National Laboratory (LBNL) first developed these ultra-thin nanosheets in 2010 using an air-and-water combination.

"We often think of oil on water as something that is environmentally bad when, in fact, my group over the past 20 years has been studying the unique properties of the junction between water and oil as an interesting place for molecules to assemble in unique ways -- including for soaps and oil dispersants," said Richmond, who holds a UO presidential chair. "This study shows it is also a unique platform for making nanosheets."

Lead authors on the project were Ellen J. Robertson, a doctoral student in Richmond's lab at the time of the research, and Gloria K. Oliver, a postdoctoral researcher at LBNL. Robertson is now a postdoctoral researcher at LBNL.

Work in Richmond's lab helped to identify the mechanism behind the formation of the nanosheets at an oil-water interface.

"Supramolecular assembly at an oil-water interface is an effective way to produce 2D nanomaterials from peptoids because that interface helps pre-organize the peptoid chains to facilitate their self-interaction," said Zuckermann, a senior scientist at LBNL's Molecular Foundry in a news release. "This increased understanding of the peptoid assembly mechanism should enable us to scale-up to produce large quantities, or scale- down, using microfluidics, to screen many different nanosheets for novel functions."

Zuckermann and Richmond are the corresponding authors on the paper. Additional co-authors are Menglu Qian and Caroline Proulx, both of LBNL.

Like natural proteins, synthetic proteins fold and conform into structures that allow them to do specific functions. In his earlier work, Zuckermann's team at LBNL's Molecular Foundry discovered a technique to synthesize peptoids into sheets that were just a few nanometers thick but up to 100 micrometers in length. These were among the largest and thinnest free-floating organic crystals ever made, with an area-to-thickness equivalent of a plastic sheet covering a football field.

"Peptoid nanosheet properties can be tailored with great precision," Zuckermann says, "and since peptoids are less vulnerable to chemical or metabolic breakdown than proteins, they are a highly promising platform for self-assembling bio-inspired nanomaterials."

To create the new version of the nanosheets, the research team used vibrational sum frequency spectroscopy to probe the molecular interactions between the peptoids as they assemble at the oil-water interface. The work showed that peptoid polymers adsorbed to the interface are highly ordered in a way that is influenced by interactions between neighboring molecules.

The substitution of oil in place of air creates a raft of new opportunities for the engineering and production of peptoid nanosheets, the researchers said. The oil phase, for example, could contain chemical reagents, serve to minimize evaporation of the aqueous phase or enable microfluidic production.

###

The U.S. Department of Energy's Office of Basic Energy Sciences (grant DE-FG02-96ER45557) supported the research done in Richmond's UO lab. Work at the Molecular Foundry at LBNL was supported by the DOE (under contract DE-AC02-05CH11231) and the Defense Threat Reduction Agency (grant IACRO-B1144571).

Media Contact: Jim Barlow, director of science and research communications, 541-346-3481, jebarlow@uoregon.edu

Sources: Geraldine Richmond is traveling but can be reached through the media contact above; Ronald Zuckermann, Molecular Foundry at Lawrence Berkeley National Laboratory, 510-486-7091, rnzuckermann@lbl.gov

Jim Barlow | Eurek Alert!

Further reports about: LBNL Molecular Oregon nanomaterials peptoid properties proteins synthetic technique

More articles from Life Sciences:

nachricht New technology helps ID aggressive early breast cancer
01.07.2016 | University of Michigan Health System

nachricht In times of great famine, microalgae digest themselves
01.07.2016 | Alfred-Wegener-Institut, Helmholtz-Zentrum für Polar- und Meeresforschung

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Mainz-based physicists find missing link between glass formation and crystallization

Densified regions with drastically reduced internal motion either act as crystal precursors or cluster and frustrate all further dynamics

Glasses are neither fluids nor crystals. They are amorphous solids and one of the big puzzles in condensed matter physics. For decades, the question of how...

Im Focus: Thousands on one chip: New Method to study Proteins

Since the completion of the human genome an important goal has been to elucidate the function of the now known proteins: a new molecular method enables the investigation of the function for thousands of proteins in parallel. Applying this new method, an international team of researchers with leading participation of the Technical University of Munich (TUM) was able to identify hundreds of previously unknown interactions among proteins.

The human genome and those of most common crops have been decoded for many years. Soon it will be possible to sequence your personal genome for less than 1000...

Im Focus: Optical lenses, hardly larger than a human hair

3D printing enables the smalles complex micro-objectives

3D printing revolutionized the manufacturing of complex shapes in the last few years. Using additive depositing of materials, where individual dots or lines...

Im Focus: Flexible OLED applications arrive

R2D2, a joint project to analyze and development high-TRL processes and technologies for manufacture of flexible organic light-emitting diodes (OLEDs) funded by the German Federal Ministry of Education and Research (BMBF) has been successfully completed.

In contrast to point light sources like LEDs made of inorganic semiconductor crystals, organic light-emitting diodes (OLEDs) are light-emitting surfaces. Their...

Im Focus: Unexpected flexibility found in odorant molecules

High resolution rotational spectroscopy reveals an unprecedented number of conformations of an odorant molecule – a new world record!

In a recent publication in the journal Physical Chemistry Chemical Physics, researchers from the Max Planck Institute for the Structure and Dynamics of Matter...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Quantum technologies to revolutionise 21st century - Nobel Laureates discuss at Lindau

30.06.2016 | Event News

International Conference ‘GEO BON’ Wants to Close Knowledge Gaps in Global Biodiversity

28.06.2016 | Event News

ERES 2016: The largest conference in the European real estate industry

09.06.2016 | Event News

 
Latest News

Mainz-based physicists find missing link between glass formation and crystallization

01.07.2016 | Physics and Astronomy

Scientists observe first signs of healing in the Antarctic ozone layer

01.07.2016 | Earth Sciences

MRI technique induces strong, enduring visual association

01.07.2016 | Medical Engineering

VideoLinks
B2B-VideoLinks
More VideoLinks >>>