The discovery could potentially lead to new therapeutic strategies for neurodegenerative diseases aimed at blocking the spread of protein misfolding throughout the brain.
The study, published in the Journal of Clinical Investigation, reveals that damaged alpha-synuclein proteins (which are implicated in Parkinson’s disease) can spread in a ‘prion-like’ manner, an infection model previously described for diseases such as BSE (mad cow disease).
“This is a significant step forward in our understanding of the potential role of cell-to-cell transfer of alpha-synuclein in Parkinson’s disease pathogenesis and we are very excited about the findings”, says Professor Patrik Brundin at Lund University, Sweden, who led a team of investigators from research centres in Denmark, France and Portugal.
A previous observation that aggregated alpha-synuclein protein gradually appears in healthy young neurons transplanted to the brains of Parkinson’s patients initially gave rise to the group’s hypothesis of cell-to-cell protein transfer. The theory has now been tested in several cell culture experiments. Dr Christian Hansen, one of the key investigators, explains the importance of the new findings:
“We have now shown that alpha-synuclein not only can transfer from one cell to another, but also that the transferred protein can seed aggregation of alpha-synuclein in recipient cells as well. This could be an important mechanism for the spread of the pathology.”
Transplant trials in mice, performed by Dr Elodie Angot, lead investigator for animal modelling in the study, strengthened the theory of cell-to-cell transfer: “Six months after Parkinson’s disease model mice were transplanted with healthy dopamine neurons, we found that the new brain cells contained human alpha-synuclein, indicating cell-to-cell transfer from the host brain to the transplants.”
These findings add further support to the research group’s hypothesis that protein aggregates crossing cellular membranes contribute to the pathogenesis of neurodegenerative diseases.
Patrik Brundin concludes, “We are one step closer to understanding how the neuropathology spreads throughout the nervous system in Parkinson’s disease, which opens up avenues for new treatments. Hopefully, in the future we will be able to inhibit this spread and slow down the relentless disease progression and worsening of symptoms in patients.”
Corresponding author: Patrik Brundin, Neuronal Survival Unit, Wallenberg Neuroscience Center, Lund University, tel. +46 768 865757, +46 46 222 05 29, email@example.com
Journal of Clinical Invesitgation article: ‘a-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells’, J Clin Invest. doi:10.1172/JCI43366.
The body's street sweepers
18.12.2017 | Ludwig-Maximilians-Universität München
Life on the edge prepares plants for climate change
18.12.2017 | Max-Planck-Institut für Entwicklungsbiologie
A study carried out by an international team of researchers and published in the journal Physical Review X shows that ion-trap technologies available today are suitable for building large-scale quantum computers. The scientists introduce trapped-ion quantum error correction protocols that detect and correct processing errors.
In order to reach their full potential, today’s quantum computer prototypes have to meet specific criteria: First, they have to be made bigger, which means...
Since 2016, German and Spanish researchers, among them scientists from the University of Göttingen, have been hunting for exoplanets with the “Carmenes”...
DNA molecules that follow specific instructions could offer more precise molecular control of synthetic chemical systems, a discovery that opens the door for engineers to create molecular machines with new and complex behaviors.
Researchers have created chemical amplifiers and a chemical oscillator using a systematic method that has the potential to embed sophisticated circuit...
MPQ scientists achieve long storage times for photonic quantum bits which break the lower bound for direct teleportation in a global quantum network.
Concerning the development of quantum memories for the realization of global quantum networks, scientists of the Quantum Dynamics Division led by Professor...
Researchers have developed a water cloaking concept based on electromagnetic forces that could eliminate an object's wake, greatly reducing its drag while...
11.12.2017 | Event News
08.12.2017 | Event News
07.12.2017 | Event News
18.12.2017 | Life Sciences
18.12.2017 | Materials Sciences
18.12.2017 | Life Sciences