Many disease-causing bacteria, such as Yersinia, Salmonella, Shigella, and Chlamydia make use of a dedicated protein transport system to transmit pathogenic proteins to host cells. These so-called type-3 secretion systems (T3SS) consist of hollow pin-like structures on the outer shell of the bacteria. Virulence proteins that are exported through this structure are transported into host cells via an unknown mechanism.
The mechanism for this transport has previously been proposed to be occurring by injection via the pin-like structure directly from the inner part of the bacterium into the cytoplasma of the host cell. These researchers at Umeå University have now shown that virulence proteins exist on the outside of the bacterium before it has bound to the host cell and that these proteins can be transported into the host cell via a bacteria-associated protein complex. These pioneering findings are a major breakthrough in our understanding of T3SS-dependent bacteria and also open new avenues for developing antibiotics that are more specific to this type of bacteria.
In modern medical research scientists are looking for new methods for delivering proteins into cancer cells. These findings may facilitate the development of such systems by making use of the T3SS protein complex.
Hans Fällman | idw
Kidney tumor: Genetic trigger discovered
18.06.2018 | Julius-Maximilians-Universität Würzburg
New type of photosynthesis discovered
18.06.2018 | Imperial College London
Moving into its fourth decade, AchemAsia is setting out for new horizons: The International Expo and Innovation Forum for Sustainable Chemical Production will take place from 21-23 May 2019 in Shanghai, China. With an updated event profile, the eleventh edition focusses on topics that are especially relevant for the Chinese process industry, putting a strong emphasis on sustainability and innovation.
Founded in 1989 as a spin-off of ACHEMA to cater to the needs of China’s then developing industry, AchemAsia has since grown into a platform where the latest...
The BMBF-funded OWICELLS project was successfully completed with a final presentation at the BMW plant in Munich. The presentation demonstrated a Li-Fi communication with a mobile robot, while the robot carried out usual production processes (welding, moving and testing parts) in a 5x5m² production cell. The robust, optical wireless transmission is based on spatial diversity; in other words, data is sent and received simultaneously by several LEDs and several photodiodes. The system can transmit data at more than 100 Mbit/s and five milliseconds latency.
Modern production technologies in the automobile industry must become more flexible in order to fulfil individual customer requirements.
An international team of scientists has discovered a new way to transfer image information through multimodal fibers with almost no distortion - even if the fiber is bent. The results of the study, to which scientist from the Leibniz-Institute of Photonic Technology Jena (Leibniz IPHT) contributed, were published on 6thJune in the highly-cited journal Physical Review Letters.
Endoscopes allow doctors to see into a patient’s body like through a keyhole. Typically, the images are transmitted via a bundle of several hundreds of optical...
Light detection and control lies at the heart of many modern device applications, such as smartphone cameras. Using graphene as a light-sensitive material for...
Water molecules exist in two different forms with almost identical physical properties. For the first time, researchers have succeeded in separating the two forms to show that they can exhibit different chemical reactivities. These results were reported by researchers from the University of Basel and their colleagues in Hamburg in the scientific journal Nature Communications.
From a chemical perspective, water is a molecule in which a single oxygen atom is linked to two hydrogen atoms. It is less well known that water exists in two...
13.06.2018 | Event News
08.06.2018 | Event News
05.06.2018 | Event News
18.06.2018 | Earth Sciences
18.06.2018 | Process Engineering
18.06.2018 | Life Sciences