Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Ultrasound improves stem cell transplants

06.09.2011
Transplantation of haematopoietic stem cells is an effective treatment for patients with malignant blood diseases. The composition and quality of the transplanted cells are crucial to the outcome. Researchers from Lund University, Sweden, have now developed a method to improve the quality of the transplanted cells using ultrasound for cell separation.

For patients with blood cancer, a blood stem cell transplant is often the only treatment that can cure the disease. The quality of the transplanted blood stem cells and the choice and composition of the transplanted cells can be crucial.

Current methods of collecting and processing stem cell products leave a lot to be desired. Recent results from Lund University indicate that it may be possible to considerably improve the quality of the blood stem cell product by using a method known as acoustic cell separation.

“The method was developed in the field of microtechnology and builds on basic engineering research from Lund University”, explains Professor Thomas Laurell, research group leader at the Faculty of Engineering. The method is expected to facilitate improvements in the processing of blood stem cells.

Associate Professor Stefan Scheding, senior consultant at the Department of Haematology at Skåne University Hospital and research group leader at the Stem Cell Centre at Lund University, is in charge of the preclinical development of the new method, which aims to effectively separate and possibly remove or concentrate cell populations which are normally found in standard blood stem cells products. The first step has been to show that the method works, by separating out platelets from stem cell products.

“Our hope is that it will become possible to produce the optimal stem cell product for each individual transplant patient”, says Stefan Scheding. “This would give us a good chance of improving the treatment of patients who would otherwise be at risk of suffering from serious transplant complications, such as graft-versus-host disease* and infections. By optimising the quality of the transplanted cells, it may even be possible to better fight the leukaemia cells that remain in the body despite the transplant treatment”, he explains.

The project is part of the research programme CellCare, which is funded by the Swedish Governmental Agency for Innovation Systems (Vinnova) and coordinated by Thomas Laurell.

Contact details:
Thomas Laurell, Thomas.Laurell@elmat.lth.se, +46 46 222 75 40 

Stefan Scheding, stefan.scheding@med.lu.se, +46 46 222 33 31
* graft-versus-host disease: a rejection reaction in some transplants such as bone marrow transplants

http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0023074

Full bibliographic information
Dykes J, Lenshof A, Åstrand-Grundström I-B, Laurell T, Scheding S (2011) Efficient Removal of Platelets from Peripheral Blood Progenitor Cell Products Using a Novel Micro-Chip Based Acoustophoretic Platform. PLoS ONE 6(8): e23074. doi:10.1371/journal.pone.0023074
The scientific article has been published in the open access journal PLoS ONE: http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0023074
Notes for editors
Contact details:
Thomas Laurell, Thomas.Laurell@elmat.lth.se, +46 46 222 75 40 

Stefan Scheding, stefan.scheding@med.lu.se, +46 46 222 33 31

Ingela Bjoerck | alfa
Further information:
http://www.lu.se

More articles from Life Sciences:

nachricht Newly designed molecule binds nitrogen
23.02.2018 | Julius-Maximilians-Universität Würzburg

nachricht Atomic Design by Water
23.02.2018 | Max-Planck-Institut für Eisenforschung GmbH

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Attoseconds break into atomic interior

A newly developed laser technology has enabled physicists in the Laboratory for Attosecond Physics (jointly run by LMU Munich and the Max Planck Institute of Quantum Optics) to generate attosecond bursts of high-energy photons of unprecedented intensity. This has made it possible to observe the interaction of multiple photons in a single such pulse with electrons in the inner orbital shell of an atom.

In order to observe the ultrafast electron motion in the inner shells of atoms with short light pulses, the pulses must not only be ultrashort, but very...

Im Focus: Good vibrations feel the force

A group of researchers led by Andrea Cavalleri at the Max Planck Institute for Structure and Dynamics of Matter (MPSD) in Hamburg has demonstrated a new method enabling precise measurements of the interatomic forces that hold crystalline solids together. The paper Probing the Interatomic Potential of Solids by Strong-Field Nonlinear Phononics, published online in Nature, explains how a terahertz-frequency laser pulse can drive very large deformations of the crystal.

By measuring the highly unusual atomic trajectories under extreme electromagnetic transients, the MPSD group could reconstruct how rigid the atomic bonds are...

Im Focus: Developing reliable quantum computers

International research team makes important step on the path to solving certification problems

Quantum computers may one day solve algorithmic problems which even the biggest supercomputers today can’t manage. But how do you test a quantum computer to...

Im Focus: In best circles: First integrated circuit from self-assembled polymer

For the first time, a team of researchers at the Max-Planck Institute (MPI) for Polymer Research in Mainz, Germany, has succeeded in making an integrated circuit (IC) from just a monolayer of a semiconducting polymer via a bottom-up, self-assembly approach.

In the self-assembly process, the semiconducting polymer arranges itself into an ordered monolayer in a transistor. The transistors are binary switches used...

Im Focus: Demonstration of a single molecule piezoelectric effect

Breakthrough provides a new concept of the design of molecular motors, sensors and electricity generators at nanoscale

Researchers from the Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague), Institute of Physics of the CAS (IP CAS) and Palacký University...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

2nd International Conference on High Temperature Shape Memory Alloys (HTSMAs)

15.02.2018 | Event News

Aachen DC Grid Summit 2018

13.02.2018 | Event News

How Global Climate Policy Can Learn from the Energy Transition

12.02.2018 | Event News

 
Latest News

Basque researchers turn light upside down

23.02.2018 | Physics and Astronomy

Finnish research group discovers a new immune system regulator

23.02.2018 | Health and Medicine

Attoseconds break into atomic interior

23.02.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>