HDAC8 overexpression is associated with a poor prognosis in human neuroblastoma patients. "As there are many different isoforms of histone deacetylases, it is crucial to understand the specific function of each -- with the putative goal of targeting a specific subset for a specific disease process," explains Dr. Mike Haberland, lead author on the study.
Dr. Olson's team explored the role of HDAC8 in verterbrate skull morphogenesis, using a strain of knockout mice specifically lacking HDAC8 in cranial neural crest cells. Neural crest cells (NCCs) are a specialized group of embryonic cells that – among other things – have evolved to generate the unsegmented vertebrate head, which has allowed vertebrates to transform from a passive, filter feeding animal into an active predator with paired eyes, an enlarged brain and protective skull, and ultimately, teeth and jaws.
The researchers found that HDAC8 deletion causes a deficiency of cranial NCCs, resulting in skull dysmorphism and instability, and perinatal death due to brain trauma. Microarray profiling revealed that HDAC8 represses multiple homeobox transcription factors that are active in the cranial NCC population, and function to pattern the frontal skull. Thus, HDAC8 has a crucial role in the epigenetic control of vertebrate skull development.
Heather Cosel-Pieper | EurekAlert!
Cryo-electron microscopy achieves unprecedented resolution using new computational methods
24.03.2017 | DOE/Lawrence Berkeley National Laboratory
How cheetahs stay fit and healthy
24.03.2017 | Forschungsverbund Berlin e.V.
Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.
The results will be published on March 22 in the journal „Astronomy & Astrophysics“.
Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...
Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...
In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...
20.03.2017 | Event News
14.03.2017 | Event News
07.03.2017 | Event News
24.03.2017 | Materials Sciences
24.03.2017 | Physics and Astronomy
24.03.2017 | Physics and Astronomy