HDAC8 overexpression is associated with a poor prognosis in human neuroblastoma patients. "As there are many different isoforms of histone deacetylases, it is crucial to understand the specific function of each -- with the putative goal of targeting a specific subset for a specific disease process," explains Dr. Mike Haberland, lead author on the study.
Dr. Olson's team explored the role of HDAC8 in verterbrate skull morphogenesis, using a strain of knockout mice specifically lacking HDAC8 in cranial neural crest cells. Neural crest cells (NCCs) are a specialized group of embryonic cells that – among other things – have evolved to generate the unsegmented vertebrate head, which has allowed vertebrates to transform from a passive, filter feeding animal into an active predator with paired eyes, an enlarged brain and protective skull, and ultimately, teeth and jaws.
The researchers found that HDAC8 deletion causes a deficiency of cranial NCCs, resulting in skull dysmorphism and instability, and perinatal death due to brain trauma. Microarray profiling revealed that HDAC8 represses multiple homeobox transcription factors that are active in the cranial NCC population, and function to pattern the frontal skull. Thus, HDAC8 has a crucial role in the epigenetic control of vertebrate skull development.
Heather Cosel-Pieper | EurekAlert!
Bare bones: Making bones transparent
27.04.2017 | California Institute of Technology
Link Discovered between Immune System, Brain Structure and Memory
26.04.2017 | Universität Basel
More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.
Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...
Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.
"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...
The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.
Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...
The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...
Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.
Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...
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