Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

UGA researchers develop first mouse model to study important aspect of Alzheimer’s

08.11.2011
Hirano bodies are almost indescribably tiny objects found in nerve cells of people suffering from conditions such as Alzheimer's, mad cow and Lou Gehrig's diseases. Yet for decades, researchers weren't sure if these structures helped cause the conditions or appeared after onset of the disease and had some other role.

Now, in research at the University of Georgia, a cellular biologist and his colleagues have found that Hirano bodies may play a protective role in the progression of neurodegenerative diseases such as Alzheimer's. And to find out why this may be happening, they have developed the world's first transgenic mouse model that has Hirano bodies, which will open new frontiers on how these poorly understood structures may be involved with some of humankind's most difficult-to-treat diseases.

"This work gives us a first view of the possible effects of Hirano bodies," said Marcus Fechheimer, Josiah Meigs Professor of cellular biology at UGA. "Now we know that Hirano bodies do not kill cells and are not toxic to mice. This new model will allow us to ask whether Hirano bodies have any effect on progression of disease in the brain."

While the research offers no cure for diseases such as Lou Gehrig's and mad cow, it does create a new area of research into understanding how these diseases operate in the human body and why they are so difficult to treat. And the problem is vast: the Alzheimer's Association reports there are 5.4 million sufferers of that disease in the U.S. alone.

The latest research announcing the transgenic mouse model for the formation of Hirano bodies was just published in the journal BMC Neuroscience. Co-authors with Fechheimer include Ruth Furukawa in the Fechheimer lab at UGA, as well as John Wagner and Michael Stramiello of the College of Veterinary Medicine, also at UGA; and Sangdeuk Ha, formerly of UGA and now with Beth Israel Deconess Medical Center at the Harvard Medical School.

Researchers actually discovered Hirano bodies decades ago but studying them in the lab proved so difficult that all the medical community could say was that the bodies were in some way associated with diseases such as Alzheimer's. It was clear that Hirano bodies are composed primarily of filaments of actin, a protein that participates in many important cellular processes. But no one understood their function.

Fechheimer's lab has been at the center of research on Hirano bodies for nearly a decade. In 2002, it reported for the first time a method of inducing the bodies to form. Interestingly, these "inclusions" also show up in autopsies of people suffering from diabetes, alcoholism and cancer. Hirano bodies also are associated with normal aging. So understanding what they do when neurological processes go off the rails could add an important step in understanding how diseases that cause so much suffering progress.

In a companion paper to the new mouse model research, published this year in the journal Neurobiology of Aging, Fechheimer and his co-authors discovered that Hirano bodies may actually act as a "corral" into which more damaging cellular molecules are "rounded up," thus actually promoting cell survival and possibly even slowing the impact of disease. The idea that Hirano bodies may actually help protect cells from such disorders as Alzheimer's came as a surprise to the team, though much research remains to be done to make sure exactly what is happening.

Co-authors on the paper in Neurobiology of Aging were Furukawa and Ha.

"The new results show us that Hirano bodies reduce cell death in a model system in a culture dish," said Fechheimer. "Now we need to know if Hirano bodies have any harmful or protective effects on cells in the brain in a mouse and in human patients. We developed the new mouse model to begin to answer this question."

The new model system will allow Fechheimer and his colleagues to study the impact of Hirano bodies in a living, mammalian system and to investigate the pathways for formation and degradation of the bodies. It will also allow them to test whether Hirano bodies promote or modulate the development of pathology or affect the deterioration of learning and memory that characterize both the human disease and the mouse models of these conditions.

The mouse model research was supported by grants from the Alzheimer's Association and the National Institutes of Health. The NIH and Alzheimer's Association, as well as the National Science Foundation also supported the research reported in Neurobiology of Aging.

Note to editors: An image of Fechheimer in his laboratory is available for download at http://multimedia.uga.edu/media/images/Fechheimer_Marcus.jpg

Marcus Fechheimer | EurekAlert!
Further information:
http://www.uga.edu

More articles from Life Sciences:

nachricht A Map of the Cell’s Power Station
18.08.2017 | Albert-Ludwigs-Universität Freiburg im Breisgau

nachricht On the way to developing a new active ingredient against chronic infections
18.08.2017 | Deutsches Zentrum für Infektionsforschung

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Fizzy soda water could be key to clean manufacture of flat wonder material: Graphene

Whether you call it effervescent, fizzy, or sparkling, carbonated water is making a comeback as a beverage. Aside from quenching thirst, researchers at the University of Illinois at Urbana-Champaign have discovered a new use for these "bubbly" concoctions that will have major impact on the manufacturer of the world's thinnest, flattest, and one most useful materials -- graphene.

As graphene's popularity grows as an advanced "wonder" material, the speed and quality at which it can be manufactured will be paramount. With that in mind,...

Im Focus: Exotic quantum states made from light: Physicists create optical “wells” for a super-photon

Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.

Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...

Im Focus: Circular RNA linked to brain function

For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.

While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...

Im Focus: RAVAN CubeSat measures Earth's outgoing energy

An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.

The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) CubeSat was launched into low-Earth orbit on Nov. 11, 2016, in order to test new...

Im Focus: Scientists shine new light on the “other high temperature superconductor”

A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.

Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Call for Papers – ICNFT 2018, 5th International Conference on New Forming Technology

16.08.2017 | Event News

Sustainability is the business model of tomorrow

04.08.2017 | Event News

Clash of Realities 2017: Registration now open. International Conference at TH Köln

26.07.2017 | Event News

 
Latest News

A Map of the Cell’s Power Station

18.08.2017 | Life Sciences

Engineering team images tiny quasicrystals as they form

18.08.2017 | Physics and Astronomy

Researchers printed graphene-like materials with inkjet

18.08.2017 | Materials Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>