Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

UEA research identifies molecules that guide embryonic heart-forming cells

06.05.2014

Scientists at the University of East Anglia have made an important step in understanding how hearts are formed in developing embryos.

The heart is the first functioning organ to develop in humans, and correct formation is crucial for embryo survival and growth.


Image above shows an early chick embryo with prospective heart cells labeled in green. These cells are migrating towards the region where they will form the heart.

New research published today reveals how cells that form the heart, known as ‘cardiac progenitors’, are guided to move into the right place for the heart to begin to form.

It is hoped that the findings will help researchers better understand how congenital heart defects happen during the early stages of pregnancy.

... more about:
»GPS »UEA »cardiac »embryos »grants »grow »humans »migrating »progenitor »signals

Researchers studied live chick embryos and used a fluorescent dye to follow how prospective heart cells move together under the microscope.

Lead researcher Prof Andrea Münsterberg, from UEA’s School of Biological Sciences, said: “We have identified two important molecules which work together to control the correct migration of these cells.

They do this by responding to signals, which help the cells navigate their way together – a bit like the embryo’s own GPS system. Once they have arrived in the correct place, they can begin to form the heart.

“Exactly how the cardiac progenitor cells are guided in their movement by these external signals is still unclear, but we have identified two key players that are important in this process.

“This research is particularly important because correct heart formation, at the right time and in the right place, is crucial for embryos to survive and grow.”

The research was funded by British Heart Foundation project grants.

‘Smad1 transcription factor integrates BMP2 and Wnt3a signals in migrating cardiac progenitor cells’ is published in the journal PNAS (Proceedings of the National Academy of Sciences) on May 5.

Lisa Horton | Eurek Alert!
Further information:
http://www.uea.ac.uk/mac/comm/media/press/2014/may/heart-cells

Further reports about: GPS UEA cardiac embryos grants grow humans migrating progenitor signals

More articles from Life Sciences:

nachricht New Model of T Cell Activation
27.05.2016 | Albert-Ludwigs-Universität Freiburg im Breisgau

nachricht Fungi – a promising source of chemical diversity
27.05.2016 | Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie - Hans-Knöll-Institut (HKI)

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Worldwide Success of Tyrolean Wastewater Treatment Technology

A biological and energy-efficient process, developed and patented by the University of Innsbruck, converts nitrogen compounds in wastewater treatment facilities into harmless atmospheric nitrogen gas. This innovative technology is now being refined and marketed jointly with the United States’ DC Water and Sewer Authority (DC Water). The largest DEMON®-system in a wastewater treatment plant is currently being built in Washington, DC.

The DEMON®-system was developed and patented by the University of Innsbruck 11 years ago. Today this successful technology has been implemented in about 70...

Im Focus: Computational high-throughput screening finds hard magnets containing less rare earth elements

Permanent magnets are very important for technologies of the future like electromobility and renewable energy, and rare earth elements (REE) are necessary for their manufacture. The Fraunhofer Institute for Mechanics of Materials IWM in Freiburg, Germany, has now succeeded in identifying promising approaches and materials for new permanent magnets through use of an in-house simulation process based on high-throughput screening (HTS). The team was able to improve magnetic properties this way and at the same time replaced REE with elements that are less expensive and readily available. The results were published in the online technical journal “Scientific Reports”.

The starting point for IWM researchers Wolfgang Körner, Georg Krugel, and Christian Elsässer was a neodymium-iron-nitrogen compound based on a type of...

Im Focus: Atomic precision: technologies for the next-but-one generation of microchips

In the Beyond EUV project, the Fraunhofer Institutes for Laser Technology ILT in Aachen and for Applied Optics and Precision Engineering IOF in Jena are developing key technologies for the manufacture of a new generation of microchips using EUV radiation at a wavelength of 6.7 nm. The resulting structures are barely thicker than single atoms, and they make it possible to produce extremely integrated circuits for such items as wearables or mind-controlled prosthetic limbs.

In 1965 Gordon Moore formulated the law that came to be named after him, which states that the complexity of integrated circuits doubles every one to two...

Im Focus: Researchers demonstrate size quantization of Dirac fermions in graphene

Characterization of high-quality material reveals important details relevant to next generation nanoelectronic devices

Quantum mechanics is the field of physics governing the behavior of things on atomic scales, where things work very differently from our everyday world.

Im Focus: Graphene: A quantum of current

When current comes in discrete packages: Viennese scientists unravel the quantum properties of the carbon material graphene

In 2010 the Nobel Prize in physics was awarded for the discovery of the exceptional material graphene, which consists of a single layer of carbon atoms...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Networking 4.0: International Laser Technology Congress AKL’16 Shows New Ways of Cooperations

24.05.2016 | Event News

Challenges of rural labor markets

20.05.2016 | Event News

International expert meeting “Health Business Connect” in France

19.05.2016 | Event News

 
Latest News

11 million Euros for research into magnetic field sensors for medical diagnostics

27.05.2016 | Awards Funding

Fungi – a promising source of chemical diversity

27.05.2016 | Life Sciences

New Model of T Cell Activation

27.05.2016 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>