Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

UCSB researchers find a way to detect stealthy, 'hypervirulent' Salmonella strains

13.04.2012
A recent discovery of "hypervirulent" Salmonella bacteria has given UC Santa Barbara researchers Michael Mahan and Douglas Heithoff a means to potentially prevent food poisoning outbreaks from these particularly powerful strains.

Their findings, in a paper titled "Intraspecies Variation in the Emergence of Hyperinfectious Bacterial Strains in Nature," have been published in the journal PLoS Pathogens.


Salmonella typhimurium (red) invades cultured human cells in this color-enhanced scanning electron micrograph. Credit: Rocky Mountain Laboratories, NIAID, NIH

Salmonella is the most common cause of infection, hospitalization, and death due to foodborne illness in the U.S. This burden may continue to worsen due to the emergence of new strains that would tax current health-control efforts. To address this problem, researchers sought out –– and found –– hypervirulent strains that present a potential risk to food safety and the livestock industry.

An international team of scientists –– which also included Robert Sinsheimer and William Shimp from UCSB; Yi Xie and Bart Weimer from UC Davis; and John House from University of Sydney, Australia –– conducted a global search for hypervirulent Salmonella strains. They were found among isolates derived from livestock, and rendered current vaccines obsolete.

Bacteria behave like a Trojan Horse, exposing their weapons only after initiating infection. "These strains exhibit this behavior in the extreme –– essentially having a '5th gear' they can switch to during infection," said Heithoff, lead author of the paper.

Previous efforts to find hypervirulent strains were unsuccessful since bacteria behave much like their less-virulent cousins after environmental exposure. "The trick was to assess their virulence during infection –– before they switch back to a less-virulent state in the lab," said Professor Mahan.

Now that researchers know what to look for, they are developing methods to rapidly detect and discriminate the more harmful strains from their less-virulent cousins. The strategy is aided by a special medium utilized by the researchers that forces the bacteria to reveal their weapons in the laboratory –– the first step in the design of therapeutics to combat them.

Humans usually get Salmonella food poisoning from eating contaminated beef, chicken, or eggs. However, animal waste can contaminate fields where fruits, nuts, and vegetables are grown, thus posing a particular health concern for vegetarians. The threat is exacerbated when these foods are not cooked. Salmonella control efforts are expensive –– recent estimates place this cost up to $14.6 billion annually in the U.S.

As hypervirulent strains pose a potential risk to human and animal health, mitigation efforts warrant researchers' careful attention. "Now that we have identified the problem –– and potential solutions –– we just need to get to work," Heithoff said.

This research was launched with support from The G. Harold & Leila Y. Mathers Foundation, which then leveraged additional funding from the U.S. Department of Agriculture, National Institutes of Health, U.S. Army, and Santa Barbara Cottage Hospital Research Program.

To read the paper, visit: http://dx.plos.org/10.1371/journal.ppat.1002647

Sonia Fernandez | EurekAlert!
Further information:
http://www.ucsb.edu

More articles from Life Sciences:

nachricht Tag it EASI – a new method for accurate protein analysis
20.06.2018 | Max-Planck-Institut für Biochemie

nachricht How to track and trace a protein: Nanosensors monitor intracellular deliveries
19.06.2018 | Universität Basel

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Temperature-controlled fiber-optic light source with liquid core

In a recent publication in the renowned journal Optica, scientists of Leibniz-Institute of Photonic Technology (Leibniz IPHT) in Jena showed that they can accurately control the optical properties of liquid-core fiber lasers and therefore their spectral band width by temperature and pressure tuning.

Already last year, the researchers provided experimental proof of a new dynamic of hybrid solitons– temporally and spectrally stationary light waves resulting...

Im Focus: Overdosing on Calcium

Nano crystals impact stem cell fate during bone formation

Scientists from the University of Freiburg and the University of Basel identified a master regulator for bone regeneration. Prasad Shastri, Professor of...

Im Focus: AchemAsia 2019 will take place in Shanghai

Moving into its fourth decade, AchemAsia is setting out for new horizons: The International Expo and Innovation Forum for Sustainable Chemical Production will take place from 21-23 May 2019 in Shanghai, China. With an updated event profile, the eleventh edition focusses on topics that are especially relevant for the Chinese process industry, putting a strong emphasis on sustainability and innovation.

Founded in 1989 as a spin-off of ACHEMA to cater to the needs of China’s then developing industry, AchemAsia has since grown into a platform where the latest...

Im Focus: First real-time test of Li-Fi utilization for the industrial Internet of Things

The BMBF-funded OWICELLS project was successfully completed with a final presentation at the BMW plant in Munich. The presentation demonstrated a Li-Fi communication with a mobile robot, while the robot carried out usual production processes (welding, moving and testing parts) in a 5x5m² production cell. The robust, optical wireless transmission is based on spatial diversity; in other words, data is sent and received simultaneously by several LEDs and several photodiodes. The system can transmit data at more than 100 Mbit/s and five milliseconds latency.

Modern production technologies in the automobile industry must become more flexible in order to fulfil individual customer requirements.

Im Focus: Sharp images with flexible fibers

An international team of scientists has discovered a new way to transfer image information through multimodal fibers with almost no distortion - even if the fiber is bent. The results of the study, to which scientist from the Leibniz-Institute of Photonic Technology Jena (Leibniz IPHT) contributed, were published on 6thJune in the highly-cited journal Physical Review Letters.

Endoscopes allow doctors to see into a patient’s body like through a keyhole. Typically, the images are transmitted via a bundle of several hundreds of optical...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Munich conference on asteroid detection, tracking and defense

13.06.2018 | Event News

2nd International Baltic Earth Conference in Denmark: “The Baltic Sea region in Transition”

08.06.2018 | Event News

ISEKI_Food 2018: Conference with Holistic View of Food Production

05.06.2018 | Event News

 
Latest News

Creating a new composite fuel for new-generation fast reactors

20.06.2018 | Materials Sciences

Game-changing finding pushes 3D-printing to the molecular limit

20.06.2018 | Materials Sciences

Could this material enable autonomous vehicles to come to market sooner?

20.06.2018 | Materials Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>