"If you look at the surfaces the bacteria have to move on, they are usually covered in goop. Bacterial cells secrete polysaccharides on surfaces, which are kind of like molasses," Wong said. "Because these polysaccharides are long polymer molecules that can get entangled, these are very viscous and can potentially impede movement. However, if you move very fast in these polymer fluids, the viscosity becomes much lower compared to when you're moving slowly. The fluid will then seem more like water than molasses. This kind of phenomenon is well known to chemical engineers and physicists."
Since the twitching motion of bacteria with TFP depends of the physical distributions of TFP on the surface of individual cells, Wong hopes that the analysis of motility patterns may in the future enable new methods for biometric "fingerprinting" of individual cells for single-cell diagnostics.
"It gives us the possibility of not just identifying species of bacteria but the possibility of also identifying individual cells. Perhaps in the future, we can look at a cell and try to find the same cell later on the basis of how it moves," he said.
The study was funded by the National Institutes of Health and the National Science Foundation. The lead authors are Fan Jin from the UCLA Department of Bioengineering, the UCLA Department Chemistry and Biochemistry, and the CNSI, and Jacinta C. Conrad of the department of chemical and biomolecular engineering at the University of Houston.The UCLA Henry Samueli School of Engineering and Applied Science, established in 1945, offers 28 academic and professional degree programs and has an enrollment of almost 5,000 students. The school's distinguished faculty are leading research to address many of the critical challenges of the 21st century, including renewable energy, clean water, health care, wireless sensing and networking, and cybersecurity. Ranked among the top 10 engineering schools at public universities nationwide, the school is home to seven multimillion-dollar interdisciplinary research centers in wireless sensor systems, nanoelectronics, nanomedicine, renewable energy, customized computing, and the smart grid, all funded by federal and private agencies. (www.engineer.ucla.edu | www.twitter.com/uclaengineering)
Wileen Wong Kromhout | EurekAlert!
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