Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Ubiquitous sugar molecule could be key to repairing deep wound without scarring

13.12.2010
Findings presented at American Society for Cell Biology's 50th annual meeting in Philadelphia

Blocking fragments of the sugar molecule hyaluronan that triggers inflammation could be the key to robust healing and less scarring in deep wounds, Canadian researchers reported at the American Society for Cell Biology's 50th Annual Meeting in Philadelphia.

In laboratory rats, the small peptide, named 15-1, which blocks fragments of the ubiquitous sugar molecule, hyaluronan, promoted wound healing, minimized scarring and forged stronger new tissue.

These effects did not occur in the untreated animals in the study, according to Cornelia Tölg, Ph.D., of the London (Ontario) Regional Cancer Program.

With collaborators in Canada and the U.S., Tölg identified peptide 15-1 for its ability to cap molecular receptors in epithelial and dermal cells that react to fragments of the hyaluronan molecule by setting off a cellular pathway linked to inflammation.

A single dose of peptide 15-1 reduced wound contraction, collagen deposits, inflammation and growth of unwanted new blood vessels in lab animals. The researchers said that these findings may have clinical implications for human wound healing.

A major component in skin, hyaluronan has been known to play a complicated although unclear role in closing deep wounds and minimizing fibrotic scarring in repaired tissue.

Until the late 1970s, hyaluronan was considered to be little more than the inert "goo" that filled the extracellular matrix, but has since emerged as a biological star in a wide range of biological processes, from embryonic heart development to tumor metastasis to wound repair.

The relationship between hyaluronan levels and tissue regeneration is paradoxical according to Tölg. Hyaluronan levels are extremely high in developing embryos and newborns, which can recover readily from surgery without scarring.

But throughout adult life, levels of intact hyaluronan drop while the proportion of broken hyaluronan molecules increases.

Thus, while the intact hyaluronan molecule promotes strong healing, hyaluronan fragments engage the receptor for hyaluronan-mediated motility (RHAMM), setting off inflammation that can result in fibrotic scarring and weak granulated tissue.

Tölg and colleagues used microscopic beads coated with hyaluronan to pinpoint two small peptides that bound to the shape of the molecule.

One of them, peptide 15-1, showed an affinity for fastening itself to hyaluronan fragments, effectively keeping them from the RHAMM.

For more information:

ASCB contacts:
Cathy Yarbrough
sciencematter@yahoo.com
858-243-1814 (cell)
215-418-5306 (Dec. 11-16)
John Fleischman
jfleischman@ascb.org
513-929-4635 (Before Dec. 11)
513-706-0212 (cell)
Cornelia Tölg, Ph.D., or Eva Turley, Ph.D.
London Health Sciences Centre/London Regional Cancer Program
CANADA
519-685-8600 ext 53677
Conny.Toelg@lhsc.on.ca
Tölg will present, "Use of Hyaluronan Binding Peptides for Control of Wound Repair Associated Fibrosis" Sunday, Dec. 12, 2010, 1-2:30 pm, Epithelia, Exhibit Halls A/B/C; Program 619, Board B1002,
Co-Authors:
C. Tölg, E. Turley, London Regional Program, London, Ontario, CANADA
R. Savani, Southwestern Medical Center, Dallas, TX
D. Bagli, Hospital for Sick Children, Toronto, Ontario, CANADA
F. Winnik, Université de Montreal, Montreal, Quebec, CANADA
M. Cowman, Polytechnic Institute of New York University, New York, NY

John Fleischman | EurekAlert!
Further information:
http://www.ascb.org

Further reports about: Cancer Ontario RHAMM biological process blood vessel hyaluronan small peptide wound healing

More articles from Life Sciences:

nachricht Researchers identify potentially druggable mutant p53 proteins that promote cancer growth
09.12.2016 | Cold Spring Harbor Laboratory

nachricht Plant-based substance boosts eyelash growth
09.12.2016 | Fraunhofer-Institut für Angewandte Polymerforschung IAP

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Electron highway inside crystal

Physicists of the University of Würzburg have made an astonishing discovery in a specific type of topological insulators. The effect is due to the structure of the materials used. The researchers have now published their work in the journal Science.

Topological insulators are currently the hot topic in physics according to the newspaper Neue Zürcher Zeitung. Only a few weeks ago, their importance was...

Im Focus: Significantly more productivity in USP lasers

In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.

Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...

Im Focus: Shape matters when light meets atom

Mapping the interaction of a single atom with a single photon may inform design of quantum devices

Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

Researchers identify potentially druggable mutant p53 proteins that promote cancer growth

09.12.2016 | Life Sciences

Scientists produce a new roadmap for guiding development & conservation in the Amazon

09.12.2016 | Ecology, The Environment and Conservation

Satellites, airport visibility readings shed light on troops' exposure to air pollution

09.12.2016 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>