UBC researchers unveil 'toolbox of MiniPromoters' for gene research and therapy
University of British Columbia researchers have led the development of a new "toolbox of MiniPromoters" for research and future therapies on brain, spinal cord and eye function.
MiniPromoters are small segments of human DNA with the ability to turn genes on and off at specific times and locations. They're important tools used by scientists and clinicians to mark cells, explore function and deliver therapeutic genetic medicine.
Gene therapy, or targeted gene replacement, is being investigated as potential therapy for neurodegenerative disorders such as Alzheimer Disease, Parkinson Disease, Huntington Disease, Multiple Sclerosis, Aniridia and cancer.
Led by Elizabeth M. Simpson, UBC Medical Genetics Professor and Senior Scientist at the Centre for Molecular Medicine and Therapeutics at the Child & Family Research Institute, an international team of 64 researchers are making available 27 new MiniPromoters, greatly expanding the current limited pool of these vital tools for research and treatment of these disorders.
Using genome analysis, the research team identified new regions of human DNA that can activate a gene in certain brain regions but not others. Further research will focus on refining the gene expression patterns and optimizing gene delivery methods in animal models.
Details of the project, called the Genome Canada Pleiades Promoter Project, are scheduled to be published online in PNAS Early Edition this week.
The Pleiades Promoter Project includes scientists highly specialized in bioinformatics, high throughput genomics, transgenic mouse technology, and neuroimaging to create a unique pipeline capable of producing and characterizing large numbers of MiniPromoters. These and other research resources are being made available at www.pleiades.org and by not-for-profit distributors to enable research worldwide.
The study's co-authors come from UBC, the Centre for Molecular Medicine and Therapeutics at the Child & Family Research Institute, the Michael Smith Genome Sciences Centre at BC Cancer Agency, Simon Fraser University and the University of Tennessee. The study was funded by Genome Canada, Genome British Columbia, GlaxoSmithKline R&D Ltd., BC Mental Health and Addiction Services, Child & Family Research Institute, and the UBC Institute of Mental Health.
Randy Schmidt | EurekAlert!
The most recent press releases about innovation >>>
Die letzten 5 Focus-News des innovations-reports im Überblick:
Satellites in near-Earth orbit are at risk due to the steady increase in space debris. But their mission in the areas of telecommunications, navigation or weather forecasts is essential for society. Fraunhofer FHR therefore develops radar-based systems which allow the detection, tracking and cataloging of even the smallest particles of debris. Satellite operators who have access to our data are in a better position to plan evasive maneuvers and prevent destructive collisions. From April, 25-29 2018, Fraunhofer FHR and its partners will exhibit the complementary radar systems TIRA and GESTRA as well as the latest radar techniques for space observation across three stands at the ILA Berlin.
The "traffic situation" in space is very tense: the Earth is currently being orbited not only by countless satellites but also by a large volume of space...
An international team of researchers has discovered a new anti-cancer protein. The protein, called LHPP, prevents the uncontrolled proliferation of cancer cells in the liver. The researchers led by Prof. Michael N. Hall from the Biozentrum, University of Basel, report in “Nature” that LHPP can also serve as a biomarker for the diagnosis and prognosis of liver cancer.
The incidence of liver cancer, also known as hepatocellular carcinoma, is steadily increasing. In the last twenty years, the number of cases has almost doubled...
In just a few weeks from now, the Chinese space station Tiangong-1 will re-enter the Earth's atmosphere where it will to a large extent burn up. It is possible that some debris will reach the Earth's surface. Tiangong-1 is orbiting the Earth uncontrolled at a speed of approx. 29,000 km/h.Currently the prognosis relating to the time of impact currently lies within a window of several days. The scientists at Fraunhofer FHR have already been monitoring Tiangong-1 for a number of weeks with their TIRA system, one of the most powerful space observation radars in the world, with a view to supporting the German Space Situational Awareness Center and the ESA with their re-entry forecasts.
Following the loss of radio contact with Tiangong-1 in 2016 and due to the low orbital height, it is now inevitable that the Chinese space station will...
Fraunhofer Institute for Organic Electronics, Electron Beam and Plasma Technology FEP, provider of research and development services for OLED lighting solutions, announces the founding of the “OLED Licht Forum” and presents latest OLED design and lighting solutions during light+building, from March 18th – 23rd, 2018 in Frankfurt a.M./Germany, at booth no. F91 in Hall 4.0.
They are united in their passion for OLED (organic light emitting diodes) lighting with all of its unique facets and application possibilities. Thus experts in...
Oceans formed before Tharsis and evolved together, shaping climate history of Mars
A new scenario seeking to explain how Mars' putative oceans came and went over the last 4 billion years implies that the oceans formed several hundred million...