Through an international collaboration, University of Alberta researchers Chris Le and Michael Weinfeld have discovered how damaged DNA is recognized and repaired. This could lead to improved treatment of cancer and other diseases.
The team, from the Faculty of Medicine & Dentistry, used a new technology to monitor the early steps in the repair of the damage. They found that the proteins that initially recognize the damage amplify the distortion of the DNA around the damaged site by bending the DNA and separating the strands of the double helix. This makes it easier for the next protein to recognize and cut out the damaged portion of the DNA. The cells then patch up the empty space using the healthy half of the DNA as a model to repair the cell to its original state.
The study was conducted using a DNA repair system operated in E. Coli, but the findings are applicable to other cells because they adopt similar systems. To study the processes, the U of A team developed an advanced bio-analytical technique that enables dynamic monitoring of bio-molecular interactions. This could be highly useful in many other studies around the world.
Le and Weinfeld's research will be published in the Proceedings of the National Academy of Sciences online early edition Monday, June 15.
For more information or to set up an interview, please contact me directly. Le is available Friday after 4 p.m. MT and all day Monday. Weinfeld is also available all day Monday. To reach Le today between 4 and 5:30, please call 780-492-6416.
Quinn Phillips | EurekAlert!
Decoding the genome's cryptic language
27.02.2017 | University of California - San Diego
New risk factors for anxiety disorders
24.02.2017 | Julius-Maximilians-Universität Würzburg
On January 15, 2009, Chesley B. Sullenberger was celebrated world-wide: after the two engines had failed due to bird strike, he and his flight crew succeeded after a glide flight with an Airbus A320 in ditching on the Hudson River. All 155 people on board were saved.
On January 15, 2009, Chesley B. Sullenberger was celebrated world-wide: after the two engines had failed due to bird strike, he and his flight crew succeeded...
In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport
Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...
The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.
The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...
Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...
13.02.2017 | Event News
10.02.2017 | Event News
09.02.2017 | Event News
27.02.2017 | Materials Sciences
27.02.2017 | Interdisciplinary Research
27.02.2017 | Life Sciences