Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

TSRI Laboratories Perform Crucial Research in Development of Promising Ebola Virus Treatment

07.08.2014

Laboratories at The Scripps Research Institute (TSRI) are investigating antibodies to fight Ebola virus, including the three antibodies recently used to treat two American health care workers infected with the Ebola virus.

The conditions of two Americans have reportedly improved since they received a highly experimental antibody cocktail called ZMapp, supplied by San Diego-based Mapp Biopharmaceutical.


Photo courtesy of The Scripps Research Institute.

Scripps Research Institute Professor Erica Ollmann Saphire heads a consortium to find the best antibody cocktail to treat deadly Ebola virus infections.

The TSRI laboratories of Professor Erica Ollmann Saphire and Assistant Professor Andrew Ward are studying the structures of these antibodies using techniques called electron microscopy, which creates high-resolution images by hitting samples with electrons, and X-ray crystallography, which determines the atomic structure of crystalline arrays of proteins.

Through these images, the team will discover exactly how the immune system molecules bind to the Ebola virus and stop it from functioning, a critical step in drug development.

... more about:
»Ebola »Health »Scripps »TSRI »Vaccine »Virus »laboratories

Ebola virus causes an extremely virulent disease that currently leads to death in 25 to 90 percent of cases. The fast-moving virus is spread via the blood or other bodily fluids of an infected person,

“What we’re showing are sites of vulnerability on the surface of the virus,” said C. Daniel Murin, a graduate student in the Saphire and Ward labs. “These are the chinks in the armor of the virus and the places were you would want your anti-serum to target.”

The ZMapp treatment is still in experimental stages and has not yet been approved for use outside the two recent cases. According to Saphire, ZMapp is one of the best antibody cocktails currently known, but there may still be ways to improve it. She is currently leading a $28 million National Institutes of Health-funded consortium to test antibody cocktails from laboratories around the world, with the goal of finding the best for neutralizing Ebola virus and the many other viruses like it.

An ideal antibody cocktail would ease symptoms and improve the prognosis of infected individuals—it could even work as a preventative measure, protecting healthcare workers before they enter an infected area.

The work on the Ebola virus is part of a larger Vaccine and Global Health Initiative at TSRI, which includes research on HIV/AIDS, influenza and tuberculosis.

More:

1. Outsmarting Viruses: A Profile of Erica Ollmann Saphire
http://www.scripps.edu/newsandviews/e_20140512/ollmann-saphire.html

2. Video: Creating a Roadmap for New Treatments
https://www.youtube.com/watch?v=eEtu-TPPR2A&list=UUYZkc-c8pRYOb-45g52Gegg

3. Consortium Wins Up to $28 Million to Find Best Ebola Treatment
http://www.scripps.edu/newsandviews/e_20140324/ollmann_saphire.html

4. TSRI’s Vaccine and Global Health Initiative
http://www.scripps.edu/philanthropy/pdfs/vaccines.pdf

About the Scripps Research Institute

The Scripps Research Institute (TSRI) is one of the world's largest independent, not-for-profit organizations focusing on research in the biomedical sciences. TSRI is internationally recognized for its contributions to science and health, including its role in laying the foundation for new treatments for cancer, rheumatoid arthritis, hemophilia, and other diseases. An institution that evolved from the Scripps Metabolic Clinic founded by philanthropist Ellen Browning Scripps in 1924, the institute now employs about 3,000 people on its campuses in La Jolla, CA, and Jupiter, FL, where its renowned scientists—including three Nobel laureates—work toward their next discoveries. The institute's graduate program, which awards PhD degrees in biology and chemistry, ranks among the top ten of its kind in the nation. For more information, see www.scripps.edu.

Contact Information

Mika Ono
mikaono@scripps.edu
858-784-2052

Mika Ono | newswise

Further reports about: Ebola Health Scripps TSRI Vaccine Virus laboratories

More articles from Life Sciences:

nachricht Shark Tagged by NSU’s Guy Harvey Research Institute Is Apparently Enjoying Time in Warm, Tropical Waters
30.03.2015 | Nova Southeastern University

nachricht Misuse of Sustainability Concept May Lead to Even More Toxic Chemical Materials
30.03.2015 | Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Experiment Provides the Best Look Yet at 'Warm Dense Matter' at Cores of Giant Planets

In an experiment at the Department of Energy's SLAC National Accelerator Laboratory, scientists precisely measured the temperature and structure of aluminum as...

Im Focus: Energy-autonomous and wireless monitoring protects marine gearboxes

The IPH presents a solution at HANNOVER MESSE 2015 to make ship traffic more reliable while decreasing the maintenance costs at the same time. In cooperation with project partners, the research institute from Hannover, Germany, has developed a sensor system which continuously monitors the condition of the marine gearbox, thus preventing breakdowns. Special feature: the monitoring system works wirelessly and energy-autonomously. The required electrical power is generated where it is needed – directly at the sensor.

As well as cars need to be certified regularly (in Germany by the TÜV – Technical Inspection Association), ships need to be inspected – if the powertrain stops...

Im Focus: 3-D satellite, GPS earthquake maps isolate impacts in real time

Method produced by UI researcher could improve reaction time to deadly, expensive quakes

When an earthquake hits, the faster first responders can get to an impacted area, the more likely infrastructure--and lives--can be saved.

Im Focus: Atlantic Ocean overturning found to slow down already today

The Atlantic overturning is one of Earth’s most important heat transport systems, pumping warm water northwards and cold water southwards. Also known as the Gulf Stream system, it is responsible for the mild climate in northwestern Europe. 

Scientists now found evidence for a slowdown of the overturning – multiple lines of observation suggest that in recent decades, the current system has been...

Im Focus: Robot inspects concrete garage floors and bridge roadways for damage

Because they are regularly subjected to heavy vehicle traffic, emissions, moisture and salt, above- and underground parking garages, as well as bridges, frequently experience large areas of corrosion. Most inspection systems to date have only been capable of inspecting smaller surface areas.

From April 13 to April 17 at the Hannover Messe (hall 2, exhibit booth C16), engineers from the Fraunhofer Institute for Nondestructive Testing IZFP will be...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

World Conference On Regenerative Medicine 2015: Registration And Abstract Submission Now Open

25.03.2015 | Event News

University presidents from all over the world meet in Hamburg

19.03.2015 | Event News

10. CeBiTec Symposium zum Big Data-Problem

17.03.2015 | Event News

 
Latest News

BLS Cargo orders 15 multisystem locomotives

30.03.2015 | Press release

Shark Tagged by NSU’s Guy Harvey Research Institute Is Apparently Enjoying Time in Warm, Tropical Waters

30.03.2015 | Life Sciences

Antarctic Ice Shelves Rapidly Thinning

30.03.2015 | Earth Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>