Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Better Treatment for Lead Poisoning Coming Soon?

15.01.2009
Removing lead from blood with selective lead receptors and magnetic nanoparticles

Lead is one of the most dangerous heavy metals and is especially toxic to children. Safe and effective detoxification processes are needed. As reported in the journal Angewandte Chemie, a Korean team led by Won Seok Han and Jong Hwa Jung has developed a new, highly promising approach.

It is based on a fluorescence receptor that selectively and strongly binds to lead ions. The trick: the receptor is bound to magnetic nanoparticles and can be removed, along with their lead cargo, in a simple hemodialysis procedure using magnets. By using these magnetic particles, the researchers were able to remove 96 % of the lead ions from blood samples mixed with lead in vitro.

Lead and lead salts are mainly ingested in foods or drinking water. Lead pipes and lead-containing glazes on ceramic vessels are often a source of lead. Usually, it is not acute lead poisoning that occurs, but rather gradual lead poisoning, in which smaller amounts of the metal are accumulated over a long period of time.

Symptoms such as muscle weakness, disorientation, memory loss, and anemia are the result. Currently, lead poisoning is treated with chelation therapy, which has serious side effects: the chelates bind to other minerals and trace elements as well as lead, removing these vital materials from the body as well. Now an alternative is on the horizon.

The researchers’ idea starts with special probes used for the detection of various specific metal ions, including lead. When a lead ion binds to such a “lead receptor”, the receptor’s fluorescence is “switched on”, causing it to glow. The receptor binds to no other metal ions, only lead. Perhaps a selective lead detector could be used for detoxification, as well as detection. The scientists synthesized a derivative of such a lead detector and also equipped the molecule with a special chemical “anchor”. They used this anchor to attach the receptor molecules to the surface of magnetic nanoparticles made of silicon-dioxide-coated nickel.

Detoxification could theoretically work like hemodialysis: the blood is diverted out of the body and into a special chamber containing the biocompatible magnetic particles. By using magnetic fields, the charged magnetic particles could be fished out. The purified blood is then reintroduced to the patient. In contrast to chelation therapy, no vital minerals or trace elements would be removed from the body in this process.

Author: Jong Hwa Jung, Gyeongsang National University, Jinju (Korea), mailto:jonghwa@gnu.ac.kr

Title: A Selective Fluoroionophore Based on BODIPY-functionalized Magnetic Silica Nanoparticles: Removal of Pb2+ from Human Blood

Angewandte Chemie International Edition 2009, 48, No. 7, doi: 10.1002/anie.200804714

Jong Hwa Jung | Angewandte Chemie
Further information:
http://pressroom.angewandte.org

More articles from Life Sciences:

nachricht New catalyst controls activation of a carbon-hydrogen bond
21.11.2017 | Emory Health Sciences

nachricht The main switch
21.11.2017 | Albert-Ludwigs-Universität Freiburg im Breisgau

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Nanoparticles help with malaria diagnosis – new rapid test in development

The WHO reports an estimated 429,000 malaria deaths each year. The disease mostly affects tropical and subtropical regions and in particular the African continent. The Fraunhofer Institute for Silicate Research ISC teamed up with the Fraunhofer Institute for Molecular Biology and Applied Ecology IME and the Institute of Tropical Medicine at the University of Tübingen for a new test method to detect malaria parasites in blood. The idea of the research project “NanoFRET” is to develop a highly sensitive and reliable rapid diagnostic test so that patient treatment can begin as early as possible.

Malaria is caused by parasites transmitted by mosquito bite. The most dangerous form of malaria is malaria tropica. Left untreated, it is fatal in most cases....

Im Focus: A “cosmic snake” reveals the structure of remote galaxies

The formation of stars in distant galaxies is still largely unexplored. For the first time, astron-omers at the University of Geneva have now been able to closely observe a star system six billion light-years away. In doing so, they are confirming earlier simulations made by the University of Zurich. One special effect is made possible by the multiple reflections of images that run through the cosmos like a snake.

Today, astronomers have a pretty accurate idea of how stars were formed in the recent cosmic past. But do these laws also apply to older galaxies? For around a...

Im Focus: Visual intelligence is not the same as IQ

Just because someone is smart and well-motivated doesn't mean he or she can learn the visual skills needed to excel at tasks like matching fingerprints, interpreting medical X-rays, keeping track of aircraft on radar displays or forensic face matching.

That is the implication of a new study which shows for the first time that there is a broad range of differences in people's visual ability and that these...

Im Focus: Novel Nano-CT device creates high-resolution 3D-X-rays of tiny velvet worm legs

Computer Tomography (CT) is a standard procedure in hospitals, but so far, the technology has not been suitable for imaging extremely small objects. In PNAS, a team from the Technical University of Munich (TUM) describes a Nano-CT device that creates three-dimensional x-ray images at resolutions up to 100 nanometers. The first test application: Together with colleagues from the University of Kassel and Helmholtz-Zentrum Geesthacht the researchers analyzed the locomotory system of a velvet worm.

During a CT analysis, the object under investigation is x-rayed and a detector measures the respective amount of radiation absorbed from various angles....

Im Focus: Researchers Develop Data Bus for Quantum Computer

The quantum world is fragile; error correction codes are needed to protect the information stored in a quantum object from the deteriorating effects of noise. Quantum physicists in Innsbruck have developed a protocol to pass quantum information between differently encoded building blocks of a future quantum computer, such as processors and memories. Scientists may use this protocol in the future to build a data bus for quantum computers. The researchers have published their work in the journal Nature Communications.

Future quantum computers will be able to solve problems where conventional computers fail today. We are still far away from any large-scale implementation,...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Ecology Across Borders: International conference brings together 1,500 ecologists

15.11.2017 | Event News

Road into laboratory: Users discuss biaxial fatigue-testing for car and truck wheel

15.11.2017 | Event News

#Berlin5GWeek: The right network for Industry 4.0

30.10.2017 | Event News

 
Latest News

Previous evidence of water on mars now identified as grainflows

21.11.2017 | Physics and Astronomy

NASA's James Webb Space Telescope completes final cryogenic testing

21.11.2017 | Physics and Astronomy

New catalyst controls activation of a carbon-hydrogen bond

21.11.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>