Lead is one of the most dangerous heavy metals and is especially toxic to children. Safe and effective detoxification processes are needed. As reported in the journal Angewandte Chemie, a Korean team led by Won Seok Han and Jong Hwa Jung has developed a new, highly promising approach.
It is based on a fluorescence receptor that selectively and strongly binds to lead ions. The trick: the receptor is bound to magnetic nanoparticles and can be removed, along with their lead cargo, in a simple hemodialysis procedure using magnets. By using these magnetic particles, the researchers were able to remove 96 % of the lead ions from blood samples mixed with lead in vitro.
Lead and lead salts are mainly ingested in foods or drinking water. Lead pipes and lead-containing glazes on ceramic vessels are often a source of lead. Usually, it is not acute lead poisoning that occurs, but rather gradual lead poisoning, in which smaller amounts of the metal are accumulated over a long period of time.
Symptoms such as muscle weakness, disorientation, memory loss, and anemia are the result. Currently, lead poisoning is treated with chelation therapy, which has serious side effects: the chelates bind to other minerals and trace elements as well as lead, removing these vital materials from the body as well. Now an alternative is on the horizon.
The researchers’ idea starts with special probes used for the detection of various specific metal ions, including lead. When a lead ion binds to such a “lead receptor”, the receptor’s fluorescence is “switched on”, causing it to glow. The receptor binds to no other metal ions, only lead. Perhaps a selective lead detector could be used for detoxification, as well as detection. The scientists synthesized a derivative of such a lead detector and also equipped the molecule with a special chemical “anchor”. They used this anchor to attach the receptor molecules to the surface of magnetic nanoparticles made of silicon-dioxide-coated nickel.
Detoxification could theoretically work like hemodialysis: the blood is diverted out of the body and into a special chamber containing the biocompatible magnetic particles. By using magnetic fields, the charged magnetic particles could be fished out. The purified blood is then reintroduced to the patient. In contrast to chelation therapy, no vital minerals or trace elements would be removed from the body in this process.
Author: Jong Hwa Jung, Gyeongsang National University, Jinju (Korea), mailto:email@example.com
Title: A Selective Fluoroionophore Based on BODIPY-functionalized Magnetic Silica Nanoparticles: Removal of Pb2+ from Human Blood
Angewandte Chemie International Edition 2009, 48, No. 7, doi: 10.1002/anie.200804714
Jong Hwa Jung | Angewandte Chemie
Further reports about: > Angewandte Chemie > Cancer treatment > Detoxification > Lead Poisoning > anemia > blood sample > ceramic vessels > dangerous heavy metals > detoxification processes > disorientation > hemodialysis > hemodialysis procedure > magnetic field > magnetic nanoparticles > memory loss > muscle weakness
Cnidarians remotely control bacteria
21.09.2017 | Christian-Albrechts-Universität zu Kiel
Immune cells may heal bleeding brain after strokes
21.09.2017 | NIH/National Institute of Neurological Disorders and Stroke
Our brains house extremely complex neuronal circuits, whose detailed structures are still largely unknown. This is especially true for the so-called cerebral cortex of mammals, where among other things vision, thoughts or spatial orientation are being computed. Here the rules by which nerve cells are connected to each other are only partly understood. A team of scientists around Moritz Helmstaedter at the Frankfiurt Max Planck Institute for Brain Research and Helene Schmidt (Humboldt University in Berlin) have now discovered a surprisingly precise nerve cell connectivity pattern in the part of the cerebral cortex that is responsible for orienting the individual animal or human in space.
The researchers report online in Nature (Schmidt et al., 2017. Axonal synapse sorting in medial entorhinal cortex, DOI: 10.1038/nature24005) that synapses in...
Whispering gallery mode (WGM) resonators are used to make tiny micro-lasers, sensors, switches, routers and other devices. These tiny structures rely on a...
Using ultrafast flashes of laser and x-ray radiation, scientists at the Max Planck Institute of Quantum Optics (Garching, Germany) took snapshots of the briefest electron motion inside a solid material to date. The electron motion lasted only 750 billionths of the billionth of a second before it fainted, setting a new record of human capability to capture ultrafast processes inside solids!
When x-rays shine onto solid materials or large molecules, an electron is pushed away from its original place near the nucleus of the atom, leaving a hole...
For the first time, physicists have successfully imaged spiral magnetic ordering in a multiferroic material. These materials are considered highly promising candidates for future data storage media. The researchers were able to prove their findings using unique quantum sensors that were developed at Basel University and that can analyze electromagnetic fields on the nanometer scale. The results – obtained by scientists from the University of Basel’s Department of Physics, the Swiss Nanoscience Institute, the University of Montpellier and several laboratories from University Paris-Saclay – were recently published in the journal Nature.
Multiferroics are materials that simultaneously react to electric and magnetic fields. These two properties are rarely found together, and their combined...
MBM ScienceBridge GmbH successfully negotiated a license agreement between University Medical Center Göttingen (UMG) and the biotech company Tissue Systems Holding GmbH about commercial use of a multi-well tissue plate for automated and reliable tissue engineering & drug testing.
MBM ScienceBridge GmbH successfully negotiated a license agreement between University Medical Center Göttingen (UMG) and the biotech company Tissue Systems...
19.09.2017 | Event News
12.09.2017 | Event News
06.09.2017 | Event News
21.09.2017 | Physics and Astronomy
21.09.2017 | Life Sciences
21.09.2017 | Health and Medicine