Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Why transplanted insulin cells die

28.08.2008
New research can enhance survival of islets transplants and improve treatment of type 1 diabetes. Transplantation of insulin-producing cell islets, so-called islets of langerhans is an appealing strategy for treatment of type 1 diabetes. But it turns out that these are short-lived, and the procedure needs to be repeated.

Now researchers at Linköping University and Uppsala University in Sweden can show that accumulation of protein aggregatess, amyloid, in the transplanted cells may be causing their death.

Until now it was not known why this insulin production ceases. The discovery now being published in The New England Journal of Medicine may change the course of diabetes research.

Transplant attempts have been carried out for more than 30 years. Hundreds of patients have had healthy insulin-producing islets of Langerhans recovered from the pancreas of donors. These transplants, which usually involve the injection of cell islets into the liver, normally go well, and the patients initially don't have to take insulin. But within a year or two years the insulin production will cease from the transplanted cells.

"We have studied this in mice, but it has naturally been difficult to do so in humans. Now we have had an opportunity to examine such transplants in an individual with type 1 diabetes," says Gunilla T. Westermark, assistant professor of cell biology at Linköping University.

In close to half of the cell islets examined, 43 percent, the researchers found lumps of amyloid.

"We previously know that amyloid production is a symptom of stress that leads to cell death in type 2 diabetes. Perhaps the same thing happens in a transplant, when cells are exposed to great stress," says Gunilla T. Westermark.

Interestingly, there were quite a few unaffected cell islets remaining in the liver. If we can prevent the production of amyloid at an early stage, these cells would be able to continue to produce insulin. One possible strategy is to create a drug; another would be to refine the methods used in transplants in order to reduce stress.

The report "Widespread amyloid deposition in transplanted human pancreatic islets" by Gunilla T. Westermark, Per Westermark, Christian Berne, and Olle Korsgren will appear in The New England Journal of Medicine on August 28.

Contact:
Gunilla T. Westermark,
cell phone: +46 (0)73-4245812.
Pressofficer Åke Hjelm: åka.hjelm@liu.se; +46-13 281 395

Åke Hjelm | idw
Further information:
http://www.vr.se
http://content.nejm.org/cgi/content/short/359/9/977

More articles from Life Sciences:

nachricht Multi-institutional collaboration uncovers how molecular machines assemble
02.12.2016 | Salk Institute

nachricht Fertilized egg cells trigger and monitor loss of sperm’s epigenetic memory
02.12.2016 | IMBA - Institut für Molekulare Biotechnologie der Österreichischen Akademie der Wissenschaften GmbH

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

Im Focus: MADMAX: Max Planck Institute for Physics takes up axion research

The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.

The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...

Im Focus: Molecules change shape when wet

Broadband rotational spectroscopy unravels structural reshaping of isolated molecules in the gas phase to accommodate water

In two recent publications in the Journal of Chemical Physics and in the Journal of Physical Chemistry Letters, researchers around Melanie Schnell from the Max...

Im Focus: Fraunhofer ISE Develops Highly Compact, High Frequency DC/DC Converter for Aviation

The efficiency of power electronic systems is not solely dependent on electrical efficiency but also on weight, for example, in mobile systems. When the weight of relevant components and devices in airplanes, for instance, is reduced, fuel savings can be achieved and correspondingly greenhouse gas emissions decreased. New materials and components based on gallium nitride (GaN) can help to reduce weight and increase the efficiency. With these new materials, power electronic switches can be operated at higher switching frequency, resulting in higher power density and lower material costs.

Researchers at the Fraunhofer Institute for Solar Energy Systems ISE together with partners have investigated how these materials can be used to make power...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

UTSA study describes new minimally invasive device to treat cancer and other illnesses

02.12.2016 | Medical Engineering

Plasma-zapping process could yield trans fat-free soybean oil product

02.12.2016 | Agricultural and Forestry Science

What do Netflix, Google and planetary systems have in common?

02.12.2016 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>