Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Toxic proteins cause neurodegeneration in motor neuron disease and dementia

08.08.2014

Recent findings in basic biomedical research might pave the way towards novel therapies


In the fruit fly Drosophila melanogaster, scientists can study very well how nerve cells are damaged: brain of an adult fly (glial cells are stained green, cell nuclei purple).

Image courtesy of Dr. Teresa Niccoli, University College London, UK

Scientists at the Max Planck Institute for Biology of Ageing in Cologne and University College London have now unearthed the way in which a specific genetic mutation leads to neuronal damage in two serious afflictions, that might even occur at once in a single person: Until now, it has been unknown what causes amyotrophic lateral sclerosis and frontotemporal dementia.

Amyotrophic lateral sclerosis is a devastating type of motor neuron disease that causes rapid weakening of muscles and death. Frontotemporal dementia is the second most common cause of dementia in people under 65. It causes distressing symptoms, including changes in personality and behaviour and problems with language and thinking.

The DNA of affected patients contains a mutation: There are thousands of repeats of a specific short segment of genetic material, whereas in unaffected persons, there are only up to thirty copies of this segment. This specific genetic alteration is the cause of illness in around eight percent of patients with this type of motor neuron disease or dementia. Eight percent is a relatively high proportion. For instance, less than one percent of the causes in Alzheimer’s disease are genetic.

Researchers at the Max Planck Institute for Biology of Ageing, the Institute of Neurology and Institute for Healthy Ageing at University College London have now discovered that the repeats in the mutant gene cause neurodegeneration by making toxic proteins.

Fruitflies can undergo neurodegeneration in a similar way to humans

Previously it was thought that the problem could be a consequence of disruption of the gene by the inserted repeats. Another theory was that the repeats produce a different type of toxic RNA molecule. It now turns out that the repeats in the mutant gene can produce a variety of proteins and that two of these are extremely toxic to nerve cells. Both are highly enriched in arginine, an amino acid.

To pinpoint the role of the toxic proteins, the researchers produced artificial repeat segments that could produce potentially toxic RNA and protein or only toxic RNA or only protein. They then introduced them into the nerve cells of fruit flies, which can undergo neurodegeneration in a similar way to humans. Repeat segments that made both RNA and protein caused striking neurodegeneration and reduced the lifespan of the flies, showing that they are a good organism in which to study these diseases. Interestingly, the protein-only repeat segments caused just as bad a neurodegeneration. In contrast, the RNA-only segments were harmless, pinpointing the role of toxic proteins in these diseases. The proteins that contained arginine were the most toxic.

These findings have uncovered a new toxic role for arginine-containing proteins in motor neuron disease and dementia, which helps in the development of drugs to fight these serious afflictions.

Original publication:
C9orf72 repeat expansions cause neurodegeneration in Drosophila through arginine-rich proteins.
Sarah Mizielinska, Sebastian Grönke, Teresa Niccoli, Charlotte E. Ridler, Emma L. Clayton, Anny Devoy, Thomas Moens, Frances E. Norona, Ione O.C. Woollacott, Julian Pietrzyk, Karen Cleverley, Andrew J. Nicoll, Stuart Pickering-Brown, Jacqueline Dols, Melissa Cabecinha, Oliver Hendrich, Pietro Fratta, Elizabeth M.C. Fisher, Linda Partridge, and Adrian M. Isaacs.
Science Express, August 7, 2014.

Weitere Informationen:

http://www.age.mpg.de

Sabine Dzuck | Max-Planck-Institut

Further reports about: Biology Max-Planck-Institut RNA dementia diseases flies humans proteins sclerosis segments toxic type

More articles from Life Sciences:

nachricht Researchers develop improved means of detecting mismatched DNA
16.09.2014 | Johns Hopkins Medicine

nachricht Cells simply avoid chromosome confusion
16.09.2014 | University of Washington Health Sciences/UW Medicine

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Anzeige

Anzeige

Event News

"Start-ups and spin-offs funding – Public and private policies", 14th October 2014

12.09.2014 | Event News

BALTIC 2014: Baltic Sea Geologists meet in Warnemünde

03.09.2014 | Event News

IT security in the digital society

27.08.2014 | Event News

 
Latest News

Cells simply avoid chromosome confusion

16.09.2014 | Life Sciences

NASA's TRMM Satellite Sees Hurricane Odile Strike Baja California

16.09.2014 | Earth Sciences

Researchers develop improved means of detecting mismatched DNA

16.09.2014 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>