Developed in collaboration with industrial scientists at Perdix and Malvern Instruments, the new process analytical technology (PAT) tool characterises particle shapes using a probe which collects images of the crystallization process. The tool will enable pharmaceutical companies to monitor and optimise these processes.
“Essentially we’re filming inside the reactor so you can see exactly what’s happening as crystals are forming – and we’ve shown that we can do this on a large scale,” says Professor Kevin Roberts of the University's Institutes of Process R&D (iPRD) and Particle Science and Engineering (IPSE). “I believe we can help the manufacturing process become faster and more efficient, which will cut waste and save money - and shorten the time it takes drugs to get to market.”
Crystallisation of drug compounds from solution is a fundamental part of the lengthy pharmaceutical processing chain. The size and shape of drug compound crystals has a significant effect on product purity and quality. It also impacts on other parts of the process, where crystals are sifted, milled and blended with other chemicals before being made into tablets or suspensions.
The Leeds technology uses a probe called the In-Situ Particle Viewer (ISPV) designed and built by Perdix, in combination with Morphologi®, a commercial image analysis software developed by Malvern Instruments.
Until now there has been little research into how crystal formation can be monitored and controlled. Optimising crystal formation at the beginning of the manufacturing process could significantly affect the efficiency of the production chain, says Professor Roberts.
He believes that technologies such as those being developed at Leeds have the potential to revolutionise the pharmaceutical manufacturing sector. “The development of new technologies and processes to ensure that drug manufacture is lean and efficient is crucial. Getting it right first time requires an in depth understanding of each of the component parts of the manufacturing chain,” he says.
“Essentially we’re working towards developing high quality ‘Six Sigma’ manufacturing processes for the pharma sector - very much mirroring the approaches already adopted by high-tech sectors such as microelectronics.”
Jo Kelly | alfa
Inactivate vaccines faster and more effectively using electron beams
23.03.2017 | Fraunhofer-Institut für Organische Elektronik, Elektronenstrahl- und Plasmatechnik FEP
Hunting pathogens at full force
22.03.2017 | Helmholtz-Zentrum für Infektionsforschung
Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.
The results will be published on March 22 in the journal „Astronomy & Astrophysics“.
Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...
Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...
In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...
20.03.2017 | Event News
14.03.2017 | Event News
07.03.2017 | Event News
23.03.2017 | Health and Medicine
23.03.2017 | Physics and Astronomy
22.03.2017 | Materials Sciences