Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Toll-like receptors play role in brain damage in newborns

23.11.2011
Two out of every thousand babies are at risk of brain damage in connection with birth. Researchers at the Sahlgrenska Academy at the University of Gothenburg, Sweden, have identified mechanisms behind these injuries, which could lead to better treatment and a richer life for the infants affected.

Roughly two in every thousand babies are at risk of suffering brain damage as a result of events before, during and after delivery. Infections in the blood or a reduced supply of oxygen and blood can lead to inflammation in the brain, causing injury. This type of brain damage, which is much more common in premature babies, can result in neurological problems such as cerebral palsy, learning difficulties and epilepsy.

Toll-like receptors

Researchers at the University of Gothenburg’s Sahlgrenska Academy have now found that toll-like receptors (TLRs) in the innate immune system play a major role in the state of the brain in newborns. The discovery could lead to better treatment and a richer life for many children.

Key role in the immature brain

Research into TLRs, which was rewarded with this year’s Nobel Prize in Physiology or Medicine, has previously shown that these receptors are involved in stroke-related brain damage in adults. The researchers in Gothenburg have now shown that TLRs are also present in the immature brain and play an important role there.

“By understanding the role of toll-like receptors in the inflammatory process following brain injury, we hope eventually to find more effective treatment strategies,” says Linnea Stridh from the Sahlgrenska Academy, who presents the results in her thesis.

Simulated brain injuries

Stridh and her colleagues used mice in their studies to simulate the brain injuries seen in newborn babies. They found that special TLRs contribute to brain damage following hypoxia, where the brain is starved of oxygen.
“An infection can activate these receptors, making the brain more sensitive to hypoxia, resulting in worse brain damage,” Stridh explains. “If these signals are blocked, the degree of brain damage is reduced.”

Barrier opened

In her thesis, Stridh also looks at a protein called occludin, which has the role of gluing together cells in the blood-brain barrier.

“Our results show that there is a reduction in occludin at a genetic level following infection,” she explains. “This can lead to the opening of the barrier, making it easier for inflammatory molecules and cells in the blood to get into the brain and cause inflammation.”

The thesis “Inflammation in the immature brain; the role of toll-like receptors” was defended on 11 November 2011. neuro

TOLL-LIKE RECEPTORS
Toll-like receptors (TLRs) are found on both the outside and inside of cells where they specialise in detecting specific molecules from hostile microorganisms. When a TLR detects a microorganism, the innate immune system is activated, causing inflammation to destroy the microorganism. Research on Toll-like receptors was awarded with the Nobel Prize in medicine 2012.

Bibliographi data:
Title: Regulation of Toll-like receptor 1 and -2 in neonatal mouse brain after hypoxia-ischemia
Authors: Linnea Stridh, Peter L.P. Smith, Andrew S Naylor, Xiaoyang Wang and Carina Mallard J.
Journal: Neuroinflammation 2011, 8:45
Link to article: http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&list_uid...
For more information, please contact: Linnea Stridh
Telephone: +46 (0)31 7863377
Mobile: +46 (0)705 764718
E-mail: linnea.stridh@neuro.gu.se

Helena Aaberg | idw
Further information:
http://www.gu.se
http://gupea.ub.gu.se/handle/2077/27809

More articles from Life Sciences:

nachricht Complementing conventional antibiotics
24.05.2018 | Goethe-Universität Frankfurt am Main

nachricht Building a brain, cell by cell: Researchers make a mini neuron network (of two)
23.05.2018 | Institute of Industrial Science, The University of Tokyo

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Molecular switch will facilitate the development of pioneering electro-optical devices

A research team led by physicists at the Technical University of Munich (TUM) has developed molecular nanoswitches that can be toggled between two structurally different states using an applied voltage. They can serve as the basis for a pioneering class of devices that could replace silicon-based components with organic molecules.

The development of new electronic technologies drives the incessant reduction of functional component sizes. In the context of an international collaborative...

Im Focus: LZH showcases laser material processing of tomorrow at the LASYS 2018

At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.

At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...

Im Focus: Self-illuminating pixels for a new display generation

There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?

At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...

Im Focus: Explanation for puzzling quantum oscillations has been found

So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics

Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...

Im Focus: Dozens of binaries from Milky Way's globular clusters could be detectable by LISA

Next-generation gravitational wave detector in space will complement LIGO on Earth

The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Save the date: Forum European Neuroscience – 07-11 July 2018 in Berlin, Germany

02.05.2018 | Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

Unique scope of UV LED technologies and applications presented in Berlin: ICULTA-2018

12.04.2018 | Event News

 
Latest News

When corals eat plastics

24.05.2018 | Ecology, The Environment and Conservation

Surgery involving ultrasound energy found to treat high blood pressure

24.05.2018 | Medical Engineering

First chip-scale broadband optical system that can sense molecules in the mid-IR

24.05.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>