John Vederas, a U of A chemistry researcher working with colleagues in Ireland, found that a strain of the common soil bacteria, Bacillus thuringiensis, produces thuricin CD, a 1:1 mixture of two compounds (peptides) that kills the potentially deadly bacteria, Clostridium difficile.
But unlike other antibacterial agents, thuricin CD does no harm to other bacteria in the human gut, which are necessary for a balanced state of health.
Clostridium difficile causes abdominal pain and diarrhea that can require hospitalization. Outbreaks of the disease can be deadly in long-term care facilities. Provincial health officials in Quebec listed a Clostridium difficile outbreak as the direct cause of death for more than 1,000 people between 2003 and 2004.
When a bacterial infection is treated with a broad spectrum antibiotic, it clears all the bacteria from the gut and Clostridium difficile can take quickly take hold.
Thuricin CD has shown promising results as a specific antibiotic treatment for Clostridium difficile in vitro and is now being tested in animals.
Brian Murphy | EurekAlert!
Single-stranded DNA and RNA origami go live
15.12.2017 | Wyss Institute for Biologically Inspired Engineering at Harvard
New antbird species discovered in Peru by LSU ornithologists
15.12.2017 | Louisiana State University
DNA molecules that follow specific instructions could offer more precise molecular control of synthetic chemical systems, a discovery that opens the door for engineers to create molecular machines with new and complex behaviors.
Researchers have created chemical amplifiers and a chemical oscillator using a systematic method that has the potential to embed sophisticated circuit...
MPQ scientists achieve long storage times for photonic quantum bits which break the lower bound for direct teleportation in a global quantum network.
Concerning the development of quantum memories for the realization of global quantum networks, scientists of the Quantum Dynamics Division led by Professor...
Researchers have developed a water cloaking concept based on electromagnetic forces that could eliminate an object's wake, greatly reducing its drag while...
Tiny pores at a cell's entryway act as miniature bouncers, letting in some electrically charged atoms--ions--but blocking others. Operating as exquisitely sensitive filters, these "ion channels" play a critical role in biological functions such as muscle contraction and the firing of brain cells.
To rapidly transport the right ions through the cell membrane, the tiny channels rely on a complex interplay between the ions and surrounding molecules,...
The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecule’s storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters.
Over the past few years, the building blocks of storage media have gotten ever smaller. But further miniaturization of the current technology is hindered by...
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