Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New technique transforms iPS cells into natural tumor killers

02.06.2010
A technique for producing natural killer T (NKT) cells, known for their role in suppressing tumor growth, has been successfully demonstrated for the first time using induced pluripotent stem (iPS) cells. The technique opens the door to effective new cell-targeted treatments for cancer.

A technique for producing natural killer T (NKT) cells, known for their role in suppressing tumor growth, has been successfully demonstrated for the first time using induced pluripotent stem (iPS) cells. Developed by researchers at RIKEN, Japan’s flagship research institution, the technique opens the door to effective new cell-targeted treatments for cancer.

Through their production of TH1 cytokines, NKT cells play an essential role in innate immune responses, protecting against tumors and virus-infected cells. Yet while clinical trials have shown that injection of the glycolipid á-GalCer can effectively activate an NKT cell antitumor response, most cancer patients have very few NKT cells, which has prevented the wider application of this therapy.

Induced pluripotent stem (iPS) cells, “all-purpose” cells capable of differentiating into any type of cell, present a potential solution to this shortage of NKT cells, but with a catch: in lymphocytes, rearrangement of genes during differentiation drastically diminishes the effectiveness of conventional iPS cell generation techniques, resulting in only a small portion of cells with the desired antitumor function.

To overcome this problem, the research team used mature NKT cells that had already undergone gene rearrangement to derive their iPS cells. As reported in the July issue of the Journal of Clinical Investigation, these iPS cells enabled them to generate large numbers of NKT cells that secrete abundant IFN-ã, a TH1 cytokine that activates antitumor functions. When tested using a mouse model, the cells successfully reproduced the effects of natural NKT cells and suppressed tumor growth, validating the approach and setting the stage for powerful clinical applications in cancer therapy.

For more information, please contact:

Dr. Hiroshi Watarai
Laboratory for Immune Regulation
RIKEN Research Center for Allergy and Immunology
Tel: +81-(0)45-503-7008 / Fax: +81-(0)45-503-7006
Dr. Haruhiko Koseki
Laboratory for Developmental Genetics
RIKEN Research Center for Allergy and Immunology
Tel: +81-(0)45-503-9689 / Fax: +81-(0)45-503-9688
Ms. Tomoko Ikawa (PI officer)
Global Relations Office
RIKEN
Tel: +81-(0)48-462-1225 / Fax: +81-(0)48-462-4715
Email: koho@riken.jp

gro-pr | Research asia research news
Further information:
http://www.riken.jp
http://www.researchsea.com

Further reports about: NKT NKT cells TH1 cell-targeted treatments iPS cells pluripotent stem tumor growth

More articles from Life Sciences:

nachricht New risk factors for anxiety disorders
24.02.2017 | Julius-Maximilians-Universität Würzburg

nachricht Stingless bees have their nests protected by soldiers
24.02.2017 | Johannes Gutenberg-Universität Mainz

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

Im Focus: Mimicking nature's cellular architectures via 3-D printing

Research offers new level of control over the structure of 3-D printed materials

Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...

Im Focus: Three Magnetic States for Each Hole

Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".

Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

Stingless bees have their nests protected by soldiers

24.02.2017 | Life Sciences

New risk factors for anxiety disorders

24.02.2017 | Life Sciences

MWC 2017: 5G Capital Berlin

24.02.2017 | Trade Fair News

VideoLinks
B2B-VideoLinks
More VideoLinks >>>