Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New technique enables faster genetic diagnosis for hereditary diseases

09.12.2008
VIB researchers connected to the University of Antwerp have developed a new method that enables them to track down the cause of hereditary diseases more quickly and efficiently.

By means of this technique, genetic tests that take a long time today - such as screening for hereditary forms of breast cancer - can be carried out much more rapidly. This finding creates new perspectives for tests that are currently expensive and difficult to perform.

Genetic screening today
Genetic screening is currently performed when, for example, several persons in a family contract the same disease. A member of the family may wonder whether it is in fact an hereditary disease, and, if so, whether he or she is a carrier and runs the risk of getting the disease or of transmitting it to his or her children. Following genetic advice, screening can be performed: whereby scientists investigate whether there is indeed a defect in the DNA of the patients in the family (provided they cooperate in the testing) or of the family member who is inquiring. On the basis of this screening, medical practitioners can provide advice regarding prevention or regarding prenatal diagnosis when the person desires to have children.

If the gene that can cause the disease is very large, or if there are several genes that can possibly lead to the disease, diagnostic centers must conduct a lot of labor-intensive studies. This results in long waiting times, with the consequences that the person inquiring remains in a state of uncertainty for a longer time, that any preventive treatment is delayed, that a desire to have children is postponed, or that children are born with a defective gene.

A new technology
Now, VIB researchers Dirk Goossens and his colleagues in Jurgen Del-Favero’s research group have developed a new method, with which several pieces of DNA can be examined simultaneously, instead of one after the other. They have succeeded in joining together two powerful existing techniques - multiplex PCR and massive parallel sequencing - making it possible to screen all of a person’s relevant hereditary matter at one time. Use of this parallel technology offers an affordable solution for molecular diagnostics of a large number of (sometimes commonly occurring) disorders.
A much quicker diagnosis
With this new technology, the molecular diagnosis of genetic diseases - such as breast cancer, cystic fibrosis, and hereditary deafness - will be carried out much faster and more cost-effectively. It takes 3 to 6 months to receive a result with the techniques that are currently in use. By comparison, the new method produces a result within only a few weeks. Moreover, not only are these tests run much more quickly, they are also very sensitive and provide a more detailed result.

Sooike Stoops | alfa
Further information:
http://www.vib.de

More articles from Life Sciences:

nachricht The balancing act: An enzyme that links endocytosis to membrane recycling
07.12.2016 | National Centre for Biological Sciences

nachricht Transforming plant cells from generalists to specialists
07.12.2016 | Duke University

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Significantly more productivity in USP lasers

In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.

Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...

Im Focus: Shape matters when light meets atom

Mapping the interaction of a single atom with a single photon may inform design of quantum devices

Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

Im Focus: MADMAX: Max Planck Institute for Physics takes up axion research

The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.

The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

NTU scientists build new ultrasound device using 3-D printing technology

07.12.2016 | Health and Medicine

The balancing act: An enzyme that links endocytosis to membrane recycling

07.12.2016 | Life Sciences

How to turn white fat brown

07.12.2016 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>