They dream of using a specialized bio-inkjet printer to grow new body parts for organ transplants or tissues for making regenerative medicine repairs to ailing bodies. Both these new therapies begin with a carefully printed mass of embryonic stem cells. And now there's progress on getting that initial mass of stem cells printed.
By extending his pioneering acoustical work that applied sound waves to generate droplets from fluids, Dr. Utkan Demirci and his team at Harvard Medical School's (Brigham and Women's Hospital) Bio-Acoustic Mems in Medicine Laboratory report encouraging preliminary results at an early and crucial point in a stem cell's career known as embroid body formation. Their research results appear in the journal Biomicrofluids, published by the American Institute of Physics.
Getting the embroid body formed correctly and without mechanical trauma is key to preserving the stem cells' astounding ability to develop into any desired tissue. Their new automated bioprinting approach appears to do this better than manual pipetting in the "hang-drop" method traditionally used.
Notes Dr. Demirci: "To have the capability to manipulate cells in a high-throughput environment reliably and repeatedly, whether it is a single cell or tens of thousands of cells in a single droplet, has the potential to enable potential solutions to many problems in medicine and engineering."
Three research results stand out:Enhanced uniformity of size and ability to control droplet size. These are key variables because they determine how the embroid bodies will grow.
Faster droplet formation. The new system delivers 160 droplets/seconds, versus 10 minutes for the hang-drop method.
The next step involves assessing the two methods to compare their effects on cell function. Says Dr. Demirci: "We are eager to take it to the next level."
The article, "Embryonic stem cell bioprinting for uniform and controlled size embryoid body formation," by Feng Xu, Banupriya Sridharan, SuiQi Wang, Umut Gurkan, Brian Syverud, and Utkan Demirci, appears in the journal Biomicrofluidics.
The American Institute of Physics is an organization of 10 physical science societies, representing more than 135,000 scientists, engineers, and educators and is one of the world's largest publishers of scientific information in physics. AIP pursues innovation in electronic publishing of scholarly journals and offers full-solution publishing services for its Member Societies. AIP publishes 13 journals; two magazines, including its flagship publication Physics Today; and the AIP Conference Proceedings series. AIP also delivers valuable resources and expertise in education and student services, science communication, government relations, career services for science and engineering professionals, statistical research, industrial outreach, and the history of physics and other sciences.
Charles E. Blue | EurekAlert!
What happens in the cell nucleus after fertilization
06.12.2016 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt
Researchers uncover protein-based “cancer signature”
05.12.2016 | Universität Basel
In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.
Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...
Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...
A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.
Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...
In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.
“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...
The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.
The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...
16.11.2016 | Event News
01.11.2016 | Event News
14.10.2016 | Event News
06.12.2016 | Materials Sciences
06.12.2016 | Medical Engineering
06.12.2016 | Power and Electrical Engineering