Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Switch protein also influences the cytoskeleton: Researchers in Bochum make a surprising discovery

21.05.2010
JBC: Unexpected functions of Ras

The protein Ras is known as the switch for cell division when it is activated. Mutations in Ras and its interaction partners can thus lead to the development of cancer. Researchers in Bochum have now discovered another unexpected capability of Ras, namely that it, by interacting with another protein, controls the synthesis of the cytoskeleton responsible for the structure and stability of the cell.

Prof. Christian Herrmann’s team managed to demonstrate Ras-controlled synthesis of the cytoskeleton in a test tube. The scientists have reported their findings in the current edition of the Journal of Biological Chemistry.

Ras mutations often lead to cancer

The Ras molecule is a member of a family of proteins that has a number of important cell functions. The molecules are either in an active or in an inactive state and are thus regarded as molecular switches. In the “on” state, Ras can interact with a further family of proteins, the so-called effectors, which in turn can result in the triggering of basic processes within the cell, such as cell division. Mutations in Ras and its effectors are a common reason for the development of cancer. The interest in research into this protein is thus commensurately high. By now scientists all over the world have highly detailed knowledge of its mode of action.

Entirely new function of Ras identified

Biochemists from the Ruhr-University in Bochum have supplemented this data with a totally unexpected function. The research group under the auspices of Prof. Christian Herrmann (Faculty of Chemistry and Biochemistry) have published a report on the Ras effector NORE1A (Novel Ras Effector 1). The scientists were able to demonstrate that NORE1A, in contrast to the well-known effectors, is not required to control cell division, but involved in the synthesis of the cytoskeleton. The cytoskeleton, which is responsible for the structure and stability of the cell, is composed of the protein tubulin, amongst others. The tubulin molecules cluster as bases. They develop into nanotubes, i.e. microtubules, and give the cell an internal structure. The Ras effector NORE1A is involved at exactly this point, the so-called nucleation of tubulin. Prof. Herrmann pointed out that it is particularly surprising that this process can be directly regulated via the molecular switch Ras. The research group managed to simulate the reaction in a test tube. The addition of Ras impedes the synthesis of the cytoskeleton.

Experimentally difficult to access

The investigation of the NORE1A-induced tubulin nucleation was experimentally difficult to access. Prof. Hermann and his research group worked with experts from the National Institute for Medical Research in London and the University of Virginia. He emphasized, that this proof that Ras amazingly enough exerts a direct regulatory effect on the microtubule cytoskeleton, could never have been attained without this close international collaboration.

Title

Christine Bee; Christian Herrmann, Anna Moshnikova; Andrei Khokhlatchev; Yulia Koryakina, Christopher D. Mellor; Justin E. Molloy; Benjamin Stieglitz: Growth and Tumor Suppressor NORE1A Is a Regulatory Node between Ras Signaling and Microtubule Nucleation. In: The Journal of Biological Chemistry, Vol. 285, Issue 21, 16258-16266, MAY 21, 2010, doi: 10.1074/jbc.M109.081562

Further Information

Prof. Christian Herrmann, Physical Chemistry I, Faculty for Chemistry and Biochemistry at the Ruhr University Bochum, 44780 Bochum, NC 6/76, Tel. 0234/32-24173, E-Mail: chr.herrmann@rub.de

Dr. Josef König | idw
Further information:
http://www.ruhr-uni-bochum.de/

More articles from Life Sciences:

nachricht Scientists unlock ability to generate new sensory hair cells
22.02.2017 | Brigham and Women's Hospital

nachricht New insights into the information processing of motor neurons
22.02.2017 | Max Planck Florida Institute for Neuroscience

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

Im Focus: Mimicking nature's cellular architectures via 3-D printing

Research offers new level of control over the structure of 3-D printed materials

Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...

Im Focus: Three Magnetic States for Each Hole

Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".

Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

Microhotplates for a smart gas sensor

22.02.2017 | Power and Electrical Engineering

Scientists unlock ability to generate new sensory hair cells

22.02.2017 | Life Sciences

Prediction: More gas-giants will be found orbiting Sun-like stars

22.02.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>