McMaster University researchers have discovered a central controller or processing unit (CPU) of a superbug's weaponry.
An article on the breakthrough appears in the high-impact journal Science today.
The team from the Michael G. DeGroote Institute for Infectious Disease Research has revealed that a small chemical, made by the superbug Staphylococcus aureus and its drug-resistant forms, determines this disease's strength and ability to infect.
The bacteria is the cause for a wide range of difficult-to-treat human infectious diseases such as pneumonia, toxic-shock syndrome and flesh-eating diseases. It has become known as the superbug as it has become increasingly resistant to antibiotics and especially troublesome in hospitals.
The discovery will provide new options for fight back and disable the virulent bacteria.
"We've found that when these small chemicals in the bacteria are shut down, the bacteria is rendered non-functional and non-infectious," said Nathan Magarvey, principal investigator for the study and an assistant professor of biochemistry and biomedical sciences at McMaster. "We're now set on hacking into this pathogen and making its system crash."
To identify these "pathogen small molecule CPUs", the researchers used cutting-edge chemical mining tools to reveal the molecular wiring associated with their formation. Then, to uncover its function, the McMaster scientists shut off its synthesis, showing that the deadly pathogens had been tamed and unable to burst open red blood cells.
The McMaster team also collaborated with the University of Western Ontario and the University of Nebraska to further delve into how this "small molecule CPU" works and functions to engage Staphylococcus aureus in its destructive and harmful behaviours.
Veronica McGuire | EurekAlert!
At last, butterflies get a bigger, better evolutionary tree
16.02.2018 | Florida Museum of Natural History
New treatment strategies for chronic kidney disease from the animal kingdom
16.02.2018 | Veterinärmedizinische Universität Wien
Breakthrough provides a new concept of the design of molecular motors, sensors and electricity generators at nanoscale
Researchers from the Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague), Institute of Physics of the CAS (IP CAS) and Palacký University...
For photographers and scientists, lenses are lifesavers. They reflect and refract light, making possible the imaging systems that drive discovery through the microscope and preserve history through cameras.
But today's glass-based lenses are bulky and resist miniaturization. Next-generation technologies, such as ultrathin cameras or tiny microscopes, require...
Scientists from the University of Zurich have succeeded for the first time in tracking individual stem cells and their neuronal progeny over months within the intact adult brain. This study sheds light on how new neurons are produced throughout life.
The generation of new nerve cells was once thought to taper off at the end of embryonic development. However, recent research has shown that the adult brain...
Theoretical physicists propose to use negative interference to control heat flow in quantum devices. Study published in Physical Review Letters
Quantum computer parts are sensitive and need to be cooled to very low temperatures. Their tiny size makes them particularly susceptible to a temperature...
Let’s say the armrest is broken in your vintage car. As things stand, you would need a lot of luck and persistence to find the right spare part. But in the world of Industrie 4.0 and production with batch sizes of one, you can simply scan the armrest and print it out. This is made possible by the first ever 3D scanner capable of working autonomously and in real time. The autonomous scanning system will be on display at the Hannover Messe Preview on February 6 and at the Hannover Messe proper from April 23 to 27, 2018 (Hall 6, Booth A30).
Part of the charm of vintage cars is that they stopped making them long ago, so it is special when you do see one out on the roads. If something breaks or...
15.02.2018 | Event News
13.02.2018 | Event News
12.02.2018 | Event News
16.02.2018 | Information Technology
16.02.2018 | Health and Medicine
16.02.2018 | Physics and Astronomy