The study, carried out by Dr. Sergio Cardoso Martín, confirmed the importance of the proposed H1 and V lines as well as considering lines J1c, U5b and T2b as significantly important demographic landmarks in the history of the evolution of European human populations.
One of the aspects that has sparked most interest in recent years in the field of Population Genetics is the postglacial repopulation of Europe that happened about 15,000 years ago. A great amount of this research has focused on the analysis of mitochondrial DNA or maternal lines, using them as a tool to assess the impact of large human migrations in the make-up of the genetic heritage of current European populations.
With his thesis entitled, Diversity of the mitochondrial genome in autochthonous populations in the Cantabrian coast area: Traces of postglacial recolonisation in Europe, Dr. Sergio Cardoso Martín explored the involvement of the Franco-Cantabrian populations of the Franco-Cantabrian refuge during the postglacial recolonisation of Europe, by analysing the variability of mitochondrial DNA. The Franco-Cantabrian refuge, extending from the south-east of France to the eastern end of the Cantabrian coast, is considered to have been the main settlement for groups of humans who arrived from the north of Europe during the last glacier age, in order to escape from the extremely adverse weather conditions.
Sergio Cardoso Martín has a degree in biochemistry and is currently working in postdoctoral research. His PhD thesis was directed by Dr.Marian Martínez De Pancorbo of the Department of Zoology and Animal Cell Biology at the Faculty of Pharmacy (UPV/EHU) and of the General Genomic Research Service: DNA Bank, and by Dr. Miguel Ángel Alfonso Sánchez, of the General Genomic Research Service: DNA Bank.Looking for genetic markers
The most frequent haplogroup amongst our samples from the Basque Country and Navarre turned out to be H, and, more concretely, the subhaplogroup H1. Also notable amongst these two populations was the high frequency of the J1c line, and particularly in the case of the north of Navarre, lines U5b and T2b also registered notable frequencies. In the Pas Valley, on the other hand, the greatest frequency corresponded to haplogroup V. The adverse climate and the orography of the terrain would have favoured a marked isolation of the populations and, in consequence, a local genetic microdifferentiation that is reflected today in the predominance of some or other maternal lines in each of the analysed populations.
Apart from presenting caracteristic haplogroups, as regards diversity, the research showed that the three autochthonous populations studied were characterised by reduced values for genetic diversity with respect to other European populations, even with respect to the rest of the Iberian Peninsula. The populations of the Basque Country and the Pas Valley, together with that of Galicia, demonstrate the lowest diversity of lines within the European context. The population of the north of Navarre showed values within the range of European populations taken as reference. The author of this study has put forward these differences in mitochondrial genome diversity as being related to the lower isolation of northern Navarre, given the powerful influences of the presence of Romans, Arabs and Jews in the region, as well as its location on the pilgrim route to Santiago de Compostela.
The comparison undertaken with other European populations showed that certain mitochondrial haplogroups presented their maximum level of frequency in the area of the Franco-Cantábrico refuge. It can be deduced from these findings that the definitory mutations of these haplogrupos could have originated in the refuge zone, or otherwise could have been transported by humans who retreated from the north of Europe, thus substantially increasing their frequency subsequently as a consequence of the genetic drift, a phenomenon known as the “founder effect”.Genetic markers of recolonisation in Europe
Lucía Álvarez | alfa
Further reports about: > Basque > Cantabrian > Cantabrian coast > Coast > DNA > Franco-Cantabrian > Genetic > Navarre > PAS > autochthonous > genetic diversity > genetic marker > genetic markers > genetic microdifferentiation > haplogroup > importance > mitochondrial DNA > populations > recolonisation
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