The study could help in the development of new treatments for serious heart conditions such as infective endocarditis.
The researchers studied the way a protein found on the surface of the bacteria Staphylococcus aureus binds to a human protein called fibronectin. Their discovery is an important step in understanding how bacteria attach to the surface of blood vessels during infection.
The high-resolution structures of parts of the bacterial protein in complex with multiple fibronectin domains reveals the efficiency with which the bacterial molecule can bind several copies of the human protein, a feature thought to play a role in infection.
Dr Jennifer Potts of the Departments of Biology and Chemistry at York, who led the research said: "Interactions of S. aureus with fibronectin were first reported more than 30 years ago, and yet we still don’t understand precisely how and why the bacteria target this human protein.
"Our studies provide a significant step toward solving that issue and could help the future development of new treatments for rare but serious conditions such as infective endocarditis, an infection of the lining or valves of the heart."
The research is published in the latest issue of the Proceedings of the National Academy of Sciences (PNAS).
The work, which was funded by the British Heart Foundation, the Biotechnology and Biological Sciences Research Council, and the Wellcome Trust, was undertaken by Dr Richard Bingham and Dr Nicola Meenan (Biology, York) in collaboration with other scientists at the Universities of York, Oxford, St Andrews, UNAM and the TAMU Health Science Centre, Institute of Biosciences and Technology, Houston.
The research used the York Structural Biology Laboratory (YSBL) at the University of York and facilities at the European Synchrotron Radiation Facility (ESRF) in Grenoble.
David Garner | alfa
Novel mechanisms of action discovered for the skin cancer medication Imiquimod
21.10.2016 | Technische Universität München
Second research flight into zero gravity
21.10.2016 | Universität Zürich
Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.
"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...
In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.
A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...
By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.
"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...
COMPAMED has become the leading international marketplace for suppliers of medical manufacturing. The trade fair, which takes place every November and is co-located to MEDICA in Dusseldorf, has been steadily growing over the past years and shows that medical technology remains a rapidly growing market.
In 2016, the joint pavilion by the IVAM Microtechnology Network, the Product Market “High-tech for Medical Devices”, will be located in Hall 8a again and will...
'Ferroelectric' materials can switch between different states of electrical polarization in response to an external electric field. This flexibility means they show promise for many applications, for example in electronic devices and computer memory. Current ferroelectric materials are highly valued for their thermal and chemical stability and rapid electro-mechanical responses, but creating a material that is scalable down to the tiny sizes needed for technologies like silicon-based semiconductors (Si-based CMOS) has proven challenging.
Now, Hiroshi Funakubo and co-workers at the Tokyo Institute of Technology, in collaboration with researchers across Japan, have conducted experiments to...
14.10.2016 | Event News
14.10.2016 | Event News
12.10.2016 | Event News
21.10.2016 | Health and Medicine
21.10.2016 | Information Technology
21.10.2016 | Materials Sciences