Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Stemming the spread of cancer

21.09.2012
Okayama University researchers demonstrate that cancer stem cells can be produced from normal stem cells for new therapies to combat cancer
Okayama University researchers demonstrate that cancer stem cells can be produced from normal stem cells for new therapies to combat cancer

(Okayama, Japan, 20 September 2012) Okayama Universityfs Masaharu Seno and colleagues have demonstrated in vitro the development of cancer stem cells (CSCs) from a type of normal stem cell exposed to their hypothetical microenvironment of a tumor. The findings are also described in the inaugural September issue of Okayama University e-Bulletin: http://www.okayama-u.ac.jp/user/kouhou/ebulletin/index.html

Cancer stem cells (CSCs) have been proposed as an explanation for the spread of cancer. These cells are tumorigenic and have the capacity of both self-renewal and differentiation into a range of various cell types. In this concept, malignant tumors provide heterogeneous aspects derived from CSCs as well as normal stem cells provide tissue specific phenotype in response to their microenvironment.
Researchers have now demonstrated in vitro the development of CSCs from a type of normal stem cell exposed to their hypothetical microenvironment of a tumor. The results are the work of a group of scientists led by Masaharu Seno, a professor of Okayama University, with his collaborators in China and the US.

The researchers cultured mouse induced pluripotent stem (miPS) cells in a conditioned medium obtained from a number of mouse cancer cell lines. Finally, a population of stem cells was kept undifferentiated and proliferating while other stem cells differentiated into specialized cells, which were incapable of proliferation any more.
Since the survived miPS cells treated with the conditioned medium were found malignantly tumorigenic in vivo, they concluded that the cells could be defined as CSCs . gThe model of CSCs and the procedure of their establishment will help study the genetic alterations and the secreted factors in the tumor microenvironment which convert miPS cells to CSCs,h explain the authors. The work should help breakthrough towards the development of new therapies to combat cancer.

Angiogenesis

Further information:
Okayama University
1-1-1 Tsushima-naka , Kita-ku ,
Okayama 700-8530, Japan
Planning and Public Information Division
E-mail: www-adm@adm.okayama-u.ac.jp
Website: http://www.okayama-u.ac.jp/index_e.html

About Okayama University

Okayama University is one of the largest comprehensive universities in Japan with roots going back to the Medical Training Place sponsored by the Lord of Okayama and established in 1870. Now with 1,300 faculty and 14,000 students, the University offers courses in specialties ranging from medicine and pharmacy to humanities and physical sciences. Okayama University is located in the heart of Japan approximately 3 hours west of Tokyo by Shinkansen.
Website: http://www.okayama-u.ac.jp/index_e.html

Journal information
Authors: Ling Chen1,2,3, Tomonari Kasai1, Yueguang Li4, Yuh Sugii1, Guoliang Jin1, Masashi Okada1, Arun Vaidyanath1, Akifumi Mizutani1, Ayano Satoh5, Takayuki Kudoh1, Mary J. C. Hendrix6, David S. Salomon7, Li Fu8, Masaharu Seno1

ETitle of original paper: A model of cancer stem cells derived from mouse induced pluripotent stem cells
EJournal, volume, pages and year: PLoS One 7, e33544 (2012).
EDigital Object Identifier (DOI): 10.1371/journal.pone.0033544

EAffiliations:
1 Department of Medical and Bioengineering Science, Graduate School of Natural Science and Technology, Okayama University, Okayama, Japan.
2 Japan Society for the Promotion of Science, Tokyo, Japan.
3 Department of Pathology, Tianjin Central Hospital of Gynecology Obstetrics, Tianjin, Peoplefs Republic of China.
4 Department of General Surgery, Tianjin 4th Centre Hospital, Tianjin, Peoplefs Republic of China.
5 Multidisciplinary Division, Okayama University, Okayama, Japan.
6 Childrenfs Memorial Research Center, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America.
7 Laboratory of Mammary Biology and Tumorigenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America.

8 State Key Laboratory of Breast Cancer Research, Department of Breast Cancer Pathology and Research Laboratory, Cancer Hospital of Tianjin Medical University, Tianjin, Peoplefs Republic of China

Source: Okayama University, Planning and Public Information Division

Adarsh Sandhu | Research asia research news
Further information:
http://www.okayama-u.ac.jp/index_e.html
http://www.researchsea.com
http://www.researchsea.com/html/article.php/aid/7426/cid/1?

More articles from Life Sciences:

nachricht Are there sustainable solutions in dealing with dwindling phosphorus resources?
16.10.2017 | Leibniz-Institut für Nutzierbiologie (FBN)

nachricht Strange undertakings: ant queens bury dead to prevent disease
13.10.2017 | Institute of Science and Technology Austria

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Smart sensors for efficient processes

Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).

When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...

Im Focus: Cold molecules on collision course

Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.

How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...

Im Focus: Shrinking the proton again!

Scientists from the Max Planck Institute of Quantum Optics, using high precision laser spectroscopy of atomic hydrogen, confirm the surprisingly small value of the proton radius determined from muonic hydrogen.

It was one of the breakthroughs of the year 2010: Laser spectroscopy of muonic hydrogen resulted in a value for the proton charge radius that was significantly...

Im Focus: New nanomaterial can extract hydrogen fuel from seawater

Hybrid material converts more sunlight and can weather seawater's harsh conditions

It's possible to produce hydrogen to power fuel cells by extracting the gas from seawater, but the electricity required to do it makes the process costly. UCF...

Im Focus: Small collisions make big impact on Mercury's thin atmosphere

Mercury, our smallest planetary neighbor, has very little to call an atmosphere, but it does have a strange weather pattern: morning micro-meteor showers.

Recent modeling along with previously published results from NASA's MESSENGER spacecraft -- short for Mercury Surface, Space Environment, Geochemistry and...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

World Health Summit 2017: International experts set the course for the future of Global Health

10.10.2017 | Event News

Climate Engineering Conference 2017 Opens in Berlin

10.10.2017 | Event News

Conference Week RRR2017 on Renewable Resources from Wet and Rewetted Peatlands

28.09.2017 | Event News

 
Latest News

A single photon reveals quantum entanglement of 16 million atoms

16.10.2017 | Physics and Astronomy

The melting ice makes the sea around Greenland less saline

16.10.2017 | Earth Sciences

On the generation of solar spicules and Alfvenic waves

16.10.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>