Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Stemming the spread of cancer

21.09.2012
Okayama University researchers demonstrate that cancer stem cells can be produced from normal stem cells for new therapies to combat cancer
Okayama University researchers demonstrate that cancer stem cells can be produced from normal stem cells for new therapies to combat cancer

(Okayama, Japan, 20 September 2012) Okayama Universityfs Masaharu Seno and colleagues have demonstrated in vitro the development of cancer stem cells (CSCs) from a type of normal stem cell exposed to their hypothetical microenvironment of a tumor. The findings are also described in the inaugural September issue of Okayama University e-Bulletin: http://www.okayama-u.ac.jp/user/kouhou/ebulletin/index.html

Cancer stem cells (CSCs) have been proposed as an explanation for the spread of cancer. These cells are tumorigenic and have the capacity of both self-renewal and differentiation into a range of various cell types. In this concept, malignant tumors provide heterogeneous aspects derived from CSCs as well as normal stem cells provide tissue specific phenotype in response to their microenvironment.
Researchers have now demonstrated in vitro the development of CSCs from a type of normal stem cell exposed to their hypothetical microenvironment of a tumor. The results are the work of a group of scientists led by Masaharu Seno, a professor of Okayama University, with his collaborators in China and the US.

The researchers cultured mouse induced pluripotent stem (miPS) cells in a conditioned medium obtained from a number of mouse cancer cell lines. Finally, a population of stem cells was kept undifferentiated and proliferating while other stem cells differentiated into specialized cells, which were incapable of proliferation any more.
Since the survived miPS cells treated with the conditioned medium were found malignantly tumorigenic in vivo, they concluded that the cells could be defined as CSCs . gThe model of CSCs and the procedure of their establishment will help study the genetic alterations and the secreted factors in the tumor microenvironment which convert miPS cells to CSCs,h explain the authors. The work should help breakthrough towards the development of new therapies to combat cancer.

Angiogenesis

Further information:
Okayama University
1-1-1 Tsushima-naka , Kita-ku ,
Okayama 700-8530, Japan
Planning and Public Information Division
E-mail: www-adm@adm.okayama-u.ac.jp
Website: http://www.okayama-u.ac.jp/index_e.html

About Okayama University

Okayama University is one of the largest comprehensive universities in Japan with roots going back to the Medical Training Place sponsored by the Lord of Okayama and established in 1870. Now with 1,300 faculty and 14,000 students, the University offers courses in specialties ranging from medicine and pharmacy to humanities and physical sciences. Okayama University is located in the heart of Japan approximately 3 hours west of Tokyo by Shinkansen.
Website: http://www.okayama-u.ac.jp/index_e.html

Journal information
Authors: Ling Chen1,2,3, Tomonari Kasai1, Yueguang Li4, Yuh Sugii1, Guoliang Jin1, Masashi Okada1, Arun Vaidyanath1, Akifumi Mizutani1, Ayano Satoh5, Takayuki Kudoh1, Mary J. C. Hendrix6, David S. Salomon7, Li Fu8, Masaharu Seno1

ETitle of original paper: A model of cancer stem cells derived from mouse induced pluripotent stem cells
EJournal, volume, pages and year: PLoS One 7, e33544 (2012).
EDigital Object Identifier (DOI): 10.1371/journal.pone.0033544

EAffiliations:
1 Department of Medical and Bioengineering Science, Graduate School of Natural Science and Technology, Okayama University, Okayama, Japan.
2 Japan Society for the Promotion of Science, Tokyo, Japan.
3 Department of Pathology, Tianjin Central Hospital of Gynecology Obstetrics, Tianjin, Peoplefs Republic of China.
4 Department of General Surgery, Tianjin 4th Centre Hospital, Tianjin, Peoplefs Republic of China.
5 Multidisciplinary Division, Okayama University, Okayama, Japan.
6 Childrenfs Memorial Research Center, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America.
7 Laboratory of Mammary Biology and Tumorigenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America.

8 State Key Laboratory of Breast Cancer Research, Department of Breast Cancer Pathology and Research Laboratory, Cancer Hospital of Tianjin Medical University, Tianjin, Peoplefs Republic of China

Source: Okayama University, Planning and Public Information Division

Adarsh Sandhu | Research asia research news
Further information:
http://www.okayama-u.ac.jp/index_e.html
http://www.researchsea.com
http://www.researchsea.com/html/article.php/aid/7426/cid/1?

More articles from Life Sciences:

nachricht One step closer to reality
20.04.2018 | Max-Planck-Institut für Entwicklungsbiologie

nachricht The dark side of cichlid fish: from cannibal to caregiver
20.04.2018 | Veterinärmedizinische Universität Wien

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Spider silk key to new bone-fixing composite

University of Connecticut researchers have created a biodegradable composite made of silk fibers that can be used to repair broken load-bearing bones without the complications sometimes presented by other materials.

Repairing major load-bearing bones such as those in the leg can be a long and uncomfortable process.

Im Focus: Writing and deleting magnets with lasers

Study published in the journal ACS Applied Materials & Interfaces is the outcome of an international effort that included teams from Dresden and Berlin in Germany, and the US.

Scientists at the Helmholtz-Zentrum Dresden-Rossendorf (HZDR) together with colleagues from the Helmholtz-Zentrum Berlin (HZB) and the University of Virginia...

Im Focus: Gamma-ray flashes from plasma filaments

Novel highly efficient and brilliant gamma-ray source: Based on model calculations, physicists of the Max PIanck Institute for Nuclear Physics in Heidelberg propose a novel method for an efficient high-brilliance gamma-ray source. A giant collimated gamma-ray pulse is generated from the interaction of a dense ultra-relativistic electron beam with a thin solid conductor. Energetic gamma-rays are copiously produced as the electron beam splits into filaments while propagating across the conductor. The resulting gamma-ray energy and flux enable novel experiments in nuclear and fundamental physics.

The typical wavelength of light interacting with an object of the microcosm scales with the size of this object. For atoms, this ranges from visible light to...

Im Focus: Basel researchers succeed in cultivating cartilage from stem cells

Stable joint cartilage can be produced from adult stem cells originating from bone marrow. This is made possible by inducing specific molecular processes occurring during embryonic cartilage formation, as researchers from the University and University Hospital of Basel report in the scientific journal PNAS.

Certain mesenchymal stem/stromal cells from the bone marrow of adults are considered extremely promising for skeletal tissue regeneration. These adult stem...

Im Focus: Like a wedge in a hinge

Researchers lay groundwork to tailor drugs for new targets in cancer therapy

In the fight against cancer, scientists are developing new drugs to hit tumor cells at so far unused weak points. Such a “sore spot” is the protein complex...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

Unique scope of UV LED technologies and applications presented in Berlin: ICULTA-2018

12.04.2018 | Event News

IWOLIA: A conference bringing together German Industrie 4.0 and French Industrie du Futur

09.04.2018 | Event News

 
Latest News

Magnetic nano-imaging on a table top

20.04.2018 | Physics and Astronomy

Start of work for the world's largest electric truck

20.04.2018 | Interdisciplinary Research

Atoms may hum a tune from grand cosmic symphony

20.04.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>