Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

The use of stem cells in regenerative medicine may also be detrimental for health

16.11.2009
The use of stem cells in regenerative medicine is not always beneficial for human health, it may even be harmful according to a work done by the University of Granada and University of León. Scientists have demonstrated that transplantation of human mononuclear cells isolated from umbilical cord blood exerted a deleterious effect in rats with liver cirrhosis.

Researchers aimed to investigate whether the mononuclear cell fraction of human cord blood (HUCBM cells), which contains stem cells, might be useful in hepatic regenerative medicine. Both histological and biochemical findings obtained in this research suggest that cell transplantation did not improve the health of sick animals but it induced a hepatorenal syndrome instead.

The authors of this work are Ana I Álvarez-Mercado, María V García-Mediavilla, Sonia Sánchez-Campos, Francisco Abadía, María J Sáez-Lara, María Cabello-Donayre, Ángel Gil, Javier González-Gallego and Luis Fontana, researchers from the University of Granada and University of León.

Research in rats

In order to evaluate the regenerative potential of HUCBM cells, researchers carried out a human-to-rat xenograft. First, liver cirrhosis was induced to rats by administration of 0.3 g/L thioacetamide (TAA) in drinking water throughout 4 months. Later on, ten million HUCBM cells were injected through the portal vein. A similar transplantation experiment was done in control rats, i. e., rats that drank water, not TAA.

TAA induced nodular cirrhosis to animals. Cell therapy did not have any effect on hepatic histology, but analysis of biochemical parameters revealed that cirrhotic rats subjected to transplantation exhibited alterations in liver fuction (lower albumin concentration and higher bilirubin concentration in plasma compared to cirrhotic rats that did not receive HUCBM cells). Also, the group with cirrhosis that received HUCBM cells showed renal damage.

Nowadays, approximately 17% of the world population is affected by liver diseases. There is to date no specific treatment for the liver fibrosis that develops in chronic hepatic diseases, and patients receive treatment for its associated complications. In addition, the current therapy for end-stage hepatic disease, whole liver transplantation, is limited by the shortage of organ donors. Accordingly, novel therapies, such as the use of cord blood stem cells, are required to alleviate the suffering of many patients. This work, however, highlights the need of further research in the area of hepatic regenerative medicine.

The work has been funded by Fondo de Investigación Sanitaria (Instituto de Salud Carlos III), FEDER, Consejería de Innovación, Ciencia y Empresa (Junta de Andalucía), Consejería de Sanidad (Junta de Castilla y León), and Federación de Cajas de Ahorro de Castilla y León. It will appear in the November issue of the journal Cell Transplantation.

Contact: Dr. Luis Fontana. Dept. Biochemistry and Molecular Biology II, School of Pharmacy, University of Granada. Phone: +34-958-242335. E-mail: fontana@ugr.es.

Luis Fontana | EurekAlert!
Further information:
http://www.ugr.es
http://www.ugr.es/local/cts461

More articles from Life Sciences:

nachricht How brains surrender to sleep
23.06.2017 | IMP - Forschungsinstitut für Molekulare Pathologie GmbH

nachricht A new technique isolates neuronal activity during memory consolidation
22.06.2017 | Spanish National Research Council (CSIC)

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Can we see monkeys from space? Emerging technologies to map biodiversity

An international team of scientists has proposed a new multi-disciplinary approach in which an array of new technologies will allow us to map biodiversity and the risks that wildlife is facing at the scale of whole landscapes. The findings are published in Nature Ecology and Evolution. This international research is led by the Kunming Institute of Zoology from China, University of East Anglia, University of Leicester and the Leibniz Institute for Zoo and Wildlife Research.

Using a combination of satellite and ground data, the team proposes that it is now possible to map biodiversity with an accuracy that has not been previously...

Im Focus: Climate satellite: Tracking methane with robust laser technology

Heatwaves in the Arctic, longer periods of vegetation in Europe, severe floods in West Africa – starting in 2021, scientists want to explore the emissions of the greenhouse gas methane with the German-French satellite MERLIN. This is made possible by a new robust laser system of the Fraunhofer Institute for Laser Technology ILT in Aachen, which achieves unprecedented measurement accuracy.

Methane is primarily the result of the decomposition of organic matter. The gas has a 25 times greater warming potential than carbon dioxide, but is not as...

Im Focus: How protons move through a fuel cell

Hydrogen is regarded as the energy source of the future: It is produced with solar power and can be used to generate heat and electricity in fuel cells. Empa researchers have now succeeded in decoding the movement of hydrogen ions in crystals – a key step towards more efficient energy conversion in the hydrogen industry of tomorrow.

As charge carriers, electrons and ions play the leading role in electrochemical energy storage devices and converters such as batteries and fuel cells. Proton...

Im Focus: A unique data centre for cosmological simulations

Scientists from the Excellence Cluster Universe at the Ludwig-Maximilians-Universität Munich have establised "Cosmowebportal", a unique data centre for cosmological simulations located at the Leibniz Supercomputing Centre (LRZ) of the Bavarian Academy of Sciences. The complete results of a series of large hydrodynamical cosmological simulations are available, with data volumes typically exceeding several hundred terabytes. Scientists worldwide can interactively explore these complex simulations via a web interface and directly access the results.

With current telescopes, scientists can observe our Universe’s galaxies and galaxy clusters and their distribution along an invisible cosmic web. From the...

Im Focus: Scientists develop molecular thermometer for contactless measurement using infrared light

Temperature measurements possible even on the smallest scale / Molecular ruby for use in material sciences, biology, and medicine

Chemists at Johannes Gutenberg University Mainz (JGU) in cooperation with researchers of the German Federal Institute for Materials Research and Testing (BAM)...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Plants are networkers

19.06.2017 | Event News

Digital Survival Training for Executives

13.06.2017 | Event News

Global Learning Council Summit 2017

13.06.2017 | Event News

 
Latest News

Quantum thermometer or optical refrigerator?

23.06.2017 | Physics and Astronomy

A 100-year-old physics problem has been solved at EPFL

23.06.2017 | Physics and Astronomy

Equipping form with function

23.06.2017 | Information Technology

VideoLinks
B2B-VideoLinks
More VideoLinks >>>