The lab of USC scientist Krzysztof Kobielak, MD, PhD has published a trio of papers in the journals Stem Cells and The Proceedings of the National Academy of Sciences (PNAS) that describe some of the factors that determine when hair grows, when it stops growing and when it falls out.
Authored by Kobielak, postdoctoral fellow Eve Kandyba, PhD, and their colleagues, the three publications focus on stem cells located in hair follicles (hfSCs), which can regenerate hair follicles as well as skin. These hfSCs are governed by the signaling pathways BMP and Wnt — which are groups of molecules that work together to control cell functions, including the cycles of hair growth.
The most recent paper, published in the journal Stem Cells in November 2013, focuses on how the gene Wnt7b activates hair growth. Without Wnt7b, hair is much shorter.
The Kobielak lab first proposed Wnt7b’s role in a January 2013 PNAS publication. The paper identified a complex network of genes — including the Wnt and BMP signaling pathways — controlling the cycles of hair growth. Reduced BMP signaling and increased Wnt signaling activate hair growth. The inverse — increased BMP signaling and decreased Wnt signaling — keeps the hfSCs in a resting state.
Both papers earned the recommendation of the Faculty of 1000, which rates top articles by leading experts in biology and medicine.
A third paper published in Stem Cells in September 2013 further clarified the workings of the BMP signaling pathway by examining the function of two key proteins, called Smad1 and Smad5. These proteins transmit the signals necessary for regulating hair stem cells during new growth.
“Collectively, these new discoveries advance basic science and, more importantly, might translate into novel therapeutics for various human diseases,” said Kobielak. “Since BMP signaling has a key regulatory role in maintaining the stability of different types of adult stem cell populations, the implication for future therapies might be potentially much broader than baldness — and could include skin regeneration for burn patients and skin cancer.”
Additional USC co-authors on the three studies were: Yvonne Leung, PhD; Yi-Bu Chen, PhD; Randall Widelitz, PhD; Cheng-Ming Chuong, MD, PhD; Virginia M. Hazen, PhD; Agnieszka Kobielak, PhD; and Samantha J. Butler, PhD.
Funding for all three studies came from the Donald E. and Delia B. Baxter Foundation Award and National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health (grants R01-AR061552 and R03-AR061028). Kandyba, the first author for all three papers, was a fellow of the California Institute for Regenerative Medicine (CIRM) – Research Training Program II in Stem Cell Biology.
Cristy Lytal | EurekAlert!
'Lipid asymmetry' plays key role in activating immune cells
20.02.2018 | Biophysical Society
New printing technique uses cells and molecules to recreate biological structures
20.02.2018 | Queen Mary University of London
For the first time, a team of researchers at the Max-Planck Institute (MPI) for Polymer Research in Mainz, Germany, has succeeded in making an integrated circuit (IC) from just a monolayer of a semiconducting polymer via a bottom-up, self-assembly approach.
In the self-assembly process, the semiconducting polymer arranges itself into an ordered monolayer in a transistor. The transistors are binary switches used...
Breakthrough provides a new concept of the design of molecular motors, sensors and electricity generators at nanoscale
Researchers from the Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague), Institute of Physics of the CAS (IP CAS) and Palacký University...
For photographers and scientists, lenses are lifesavers. They reflect and refract light, making possible the imaging systems that drive discovery through the microscope and preserve history through cameras.
But today's glass-based lenses are bulky and resist miniaturization. Next-generation technologies, such as ultrathin cameras or tiny microscopes, require...
Scientists from the University of Zurich have succeeded for the first time in tracking individual stem cells and their neuronal progeny over months within the intact adult brain. This study sheds light on how new neurons are produced throughout life.
The generation of new nerve cells was once thought to taper off at the end of embryonic development. However, recent research has shown that the adult brain...
Theoretical physicists propose to use negative interference to control heat flow in quantum devices. Study published in Physical Review Letters
Quantum computer parts are sensitive and need to be cooled to very low temperatures. Their tiny size makes them particularly susceptible to a temperature...
15.02.2018 | Event News
13.02.2018 | Event News
12.02.2018 | Event News
20.02.2018 | Life Sciences
20.02.2018 | Medical Engineering
20.02.2018 | Physics and Astronomy