Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Stem cells offer clues to reversing receding hairlines

19.12.2013
Regenerative medicine may offer ways to banish baldness that don’t involve toupees.

The lab of USC scientist Krzysztof Kobielak, MD, PhD has published a trio of papers in the journals Stem Cells and The Proceedings of the National Academy of Sciences (PNAS) that describe some of the factors that determine when hair grows, when it stops growing and when it falls out.

Authored by Kobielak, postdoctoral fellow Eve Kandyba, PhD, and their colleagues, the three publications focus on stem cells located in hair follicles (hfSCs), which can regenerate hair follicles as well as skin. These hfSCs are governed by the signaling pathways BMP and Wnt — which are groups of molecules that work together to control cell functions, including the cycles of hair growth.

The most recent paper, published in the journal Stem Cells in November 2013, focuses on how the gene Wnt7b activates hair growth. Without Wnt7b, hair is much shorter.

The Kobielak lab first proposed Wnt7b’s role in a January 2013 PNAS publication. The paper identified a complex network of genes — including the Wnt and BMP signaling pathways — controlling the cycles of hair growth. Reduced BMP signaling and increased Wnt signaling activate hair growth. The inverse — increased BMP signaling and decreased Wnt signaling — keeps the hfSCs in a resting state.

Both papers earned the recommendation of the Faculty of 1000, which rates top articles by leading experts in biology and medicine.

A third paper published in Stem Cells in September 2013 further clarified the workings of the BMP signaling pathway by examining the function of two key proteins, called Smad1 and Smad5. These proteins transmit the signals necessary for regulating hair stem cells during new growth.

“Collectively, these new discoveries advance basic science and, more importantly, might translate into novel therapeutics for various human diseases,” said Kobielak. “Since BMP signaling has a key regulatory role in maintaining the stability of different types of adult stem cell populations, the implication for future therapies might be potentially much broader than baldness — and could include skin regeneration for burn patients and skin cancer.”

Additional USC co-authors on the three studies were: Yvonne Leung, PhD; Yi-Bu Chen, PhD; Randall Widelitz, PhD; Cheng-Ming Chuong, MD, PhD; Virginia M. Hazen, PhD; Agnieszka Kobielak, PhD; and Samantha J. Butler, PhD.

Funding for all three studies came from the Donald E. and Delia B. Baxter Foundation Award and National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health (grants R01-AR061552 and R03-AR061028). Kandyba, the first author for all three papers, was a fellow of the California Institute for Regenerative Medicine (CIRM) – Research Training Program II in Stem Cell Biology.

Cristy Lytal | EurekAlert!
Further information:
http://www.usc.edu
http://stemcell.usc.edu/2013/12/18/stem-cells-offer-clues-to-reversing-receding-hairlines/

More articles from Life Sciences:

nachricht Cryo-electron microscopy achieves unprecedented resolution using new computational methods
24.03.2017 | DOE/Lawrence Berkeley National Laboratory

nachricht How cheetahs stay fit and healthy
24.03.2017 | Forschungsverbund Berlin e.V.

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Giant Magnetic Fields in the Universe

Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.

The results will be published on March 22 in the journal „Astronomy & Astrophysics“.

Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...

Im Focus: Tracing down linear ubiquitination

Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.

Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...

Im Focus: Perovskite edges can be tuned for optoelectronic performance

Layered 2D material improves efficiency for solar cells and LEDs

In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...

Im Focus: Polymer-coated silicon nanosheets as alternative to graphene: A perfect team for nanoelectronics

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...

Im Focus: Researchers Imitate Molecular Crowding in Cells

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

International Land Use Symposium ILUS 2017: Call for Abstracts and Registration open

20.03.2017 | Event News

CONNECT 2017: International congress on connective tissue

14.03.2017 | Event News

ICTM Conference: Turbine Construction between Big Data and Additive Manufacturing

07.03.2017 | Event News

 
Latest News

Argon is not the 'dope' for metallic hydrogen

24.03.2017 | Materials Sciences

Astronomers find unexpected, dust-obscured star formation in distant galaxy

24.03.2017 | Physics and Astronomy

Gravitational wave kicks monster black hole out of galactic core

24.03.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>