The alarm bell halts the process of cell division in its tracks, preventing an error that could lead to runaway cell division and eventually, tumor formation.
"Our work suggests that to be able to prevent abnormal cell proliferation, which could lead to cancer, stem cells developed this self-checking system, what we're calling a checkpoint," said Yukiko Yamashita of the University of Michigan's Life Sciences Institute.
"And if it looks like the cell is going to divide in the wrong way, the checkpoint senses there's a problem and sends the signal: 'Don't divide! Don't divide!'" said Yamashita, a research assistant professor of life sciences and an assistant professor of cell and developmental biology at the U-M Medical School.
If everything looks OK, the checkpoint allows adult stem-cell division to proceed, providing new cells to replace damaged and worn-out tissues.
Yamashita and her colleagues have not yet identified the molecules that form the checkpoint mechanism. But they've seen it at work in adult stem cells of the fruit-fly testes, so-called germ-line stem cells.
"Aging is too few divisions and cancer is too many divisions, and people have long speculated that some process controls the balance between them," Yamashita said. "We may have found the mechanism that maintains the delicate balance between over-proliferation---which can lead to cancer---and aging."
The team's findings will be published Oct. 15 in the online version of the journal Nature.
If humans possess a similar checkpoint system and if researchers could someday harness it, they could fine-tune the rate of cellular division to control tumor development as well as tissue aging. But Yamashita stressed that no mammal studies of the checkpoint have been undertaken, so talk of potential human applications is highly speculative.
In fruit flies, the checkpoint monitors germ-line stem cells as they're about to divide. It can sense problems that would derail the division process, which is called mitosis.
Under normal conditions, adult stem-cell division creates one new stem cell and one cell committed to develop into a specific tissue type – such as a skin cell, a blood cell or, in this case, a sperm cell. That form of mitosis is called asymmetric division, and it's exactly what stem cells need to maintain a healthy balance between uncommitted and committed cells.
Cell division is controlled in part by the location of a pair of cellular components called centrosomes. They provide the framework that helps direct how chromosomes are distributed between daughter cells during mitosis.
Normally, centrosomes in a dividing stem cell remain perpendicular to an adjoining messenger cell called the hub. Yamashita and her colleagues found that improper orientation of the centrosomes disrupts the mitotic machinery, steering it on a course toward stem-cell over-proliferation and cancer.
The checkpoint mechanism senses when centrosomes are misaligned, then sounds the alarm that stops cell division.
By preventing faulty cell division, the checkpoint helps ward off cancer. But a balance must be struck: If the checkpoint mechanism slows cell division to a trickle, the resulting shortage of new cells will accelerate tissue aging.
"It's a double-edged sword, and both outcomes are bad," she said. "One path leads to cancer and the other leads to aging. And we haven't found a way to avoid aging without getting cancer."
Jim Erickson | EurekAlert!
Flow of cerebrospinal fluid regulates neural stem cell division
22.05.2018 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt
Chemists at FAU successfully demonstrate imine hydrogenation with inexpensive main group metal
22.05.2018 | Friedrich-Alexander-Universität Erlangen-Nürnberg
So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics
Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...
The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...
A team led by Austrian experimental physicist Rainer Blatt has succeeded in characterizing the quantum entanglement of two spatially separated atoms by observing their light emission. This fundamental demonstration could lead to the development of highly sensitive optical gradiometers for the precise measurement of the gravitational field or the earth's magnetic field.
The age of quantum technology has long been heralded. Decades of research into the quantum world have led to the development of methods that make it possible...
Cardiovascular tissue engineering aims to treat heart disease with prostheses that grow and regenerate. Now, researchers from the University of Zurich, the Technical University Eindhoven and the Charité Berlin have successfully implanted regenerative heart valves, designed with the aid of computer simulations, into sheep for the first time.
Producing living tissue or organs based on human cells is one of the main research fields in regenerative medicine. Tissue engineering, which involves growing...
A team of scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg investigated optically-induced superconductivity in the alkali-doped fulleride K3C60under high external pressures. This study allowed, on one hand, to uniquely assess the nature of the transient state as a superconducting phase. In addition, it unveiled the possibility to induce superconductivity in K3C60 at temperatures far above the -170 degrees Celsius hypothesized previously, and rather all the way to room temperature. The paper by Cantaluppi et al has been published in Nature Physics.
Unlike ordinary metals, superconductors have the unique capability of transporting electrical currents without any loss. Nowadays, their technological...
02.05.2018 | Event News
13.04.2018 | Event News
12.04.2018 | Event News
18.05.2018 | Power and Electrical Engineering
18.05.2018 | Information Technology
18.05.2018 | Information Technology