Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


Special issue of Gut Microbes on Helicobacter pylori

A special issue on Helicobacter pylori has been published by Landes Bioscience (Austin, TX USA). The articles contained in this special issue of the journal Gut Microbes have been authored by world-class investigators and provide new insights into the pathophysiology, diagnosis, prevention, and treatment of this microbe.

Helicobacter pylori is a gram-negative, microaerophilic bacterium found in the stomach. Identified in the early 1980s, it was shown to be present in patients with chronic gastritis and gastric ulcers, conditions that were not previously believed to have a microbial cause. It is also linked to the development of duodenal ulcers and stomach cancer.

However, in over 80% of carriers, H. pylori does not cause symptoms and it has been suggested that the bacterium may play an important role in the natural stomach ecology. H. pylori is the most common bacterial infection worldwide, with more than half of the world's population harboring the bacterium in the upper gastrointestinal tract. While incidence is decreasing in Western countries, H. pylori infection is highly prevalent in developing countries. In the absence of targeted antimicrobial therapy, colonization typically lasts for decades.

Dr Richard Peek from Vanderbilt-Ingram Cancer Center and Cancer Biology (Nashville, TN USA) has worked with the editorial team of Gut Microbes to organize this special issue on H. pylori. Papers in the issue discuss the role of childhood infection in the sequelae of H. pylori disease (Guillermo Perez-Perez), how glyco-conjugates promote virulence of H. pylori (M Stephen Trent), interplay of various H. pylori factors with host protein receptors (Steffen Backert), the role of chronic inflammation and oxidative stress in H. pylori induced gastric cancer (Keith T Wilson), diet, microbial virulence, and H. pylori induced gastric cancer (Timothy L Cover), consequences of H. pylori infection in children in developing countries (Jean E Crabtree), role of the gastrointestinal microbiome in H. pylori pathogenesis (James G Fox), biomarkers of H. pylori associated gastric cancer (Jay V Solnick), H. pylori therapies in light of evolving resistance (Francis Mégraud), benefits of H. pylori treatment in childhood (Karen J Goodman), vaccination against H. pylori (Steven J Czinn), and a study investigating the influence of H. pylori on hepatitis C virus-associated liver cancer.

In an accompanying editorial, Dr Peek highlights the importance of understanding the relationship between H. pylori infection and carcinogenesis. He writes, "Delineation of bacterial, host, and environmental mediators that augment gastric cancer risk has profound ramifications for both physicians and biomedical researchers, as such findings will not only focus prevention approaches that target H. pylori-infected human populations at increased risk for stomach cancer, but will also provide mechanistic insights into inflammatory carcinomas that develop beyond the gastric niche." The full issue is available at the following link:

Published by Landes Bioscience since 2010, Gut Microbes is a multi-disciplinary journal dedicated to bringing together basic and clinical research on all apects of microorganisms populating the intestine. Established in 2002, Landes Bioscience is an Austin, Texas-based publisher of biology research journals and books. For more information on Landes Bioscience, please visit

Andrew Thompson | EurekAlert!
Further information:

More articles from Life Sciences:

nachricht Biologists unravel another mystery of what makes DNA go 'loopy'
16.03.2018 | Emory Health Sciences

nachricht Scientists map the portal to the cell's nucleus
16.03.2018 | Rockefeller University

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Locomotion control with photopigments

Researchers from Göttingen University discover additional function of opsins

Animal photoreceptors capture light with photopigments. Researchers from the University of Göttingen have now discovered that these photopigments fulfill an...

Im Focus: Surveying the Arctic: Tracking down carbon particles

Researchers embark on aerial campaign over Northeast Greenland

On 15 March, the AWI research aeroplane Polar 5 will depart for Greenland. Concentrating on the furthest northeast region of the island, an international team...

Im Focus: Unique Insights into the Antarctic Ice Shelf System

Data collected on ocean-ice interactions in the little-researched regions of the far south

The world’s second-largest ice shelf was the destination for a Polarstern expedition that ended in Punta Arenas, Chile on 14th March 2018. Oceanographers from...

Im Focus: ILA 2018: Laser alternative to hexavalent chromium coating

At the 2018 ILA Berlin Air Show from April 25–29, the Fraunhofer Institute for Laser Technology ILT is showcasing extreme high-speed Laser Material Deposition (EHLA): A video documents how for metal components that are highly loaded, EHLA has already proved itself as an alternative to hard chrome plating, which is now allowed only under special conditions.

When the EU restricted the use of hexavalent chromium compounds to special applications requiring authorization, the move prompted a rethink in the surface...

Im Focus: Radar for navigation support from autonomous flying drones

At the ILA Berlin, hall 4, booth 202, Fraunhofer FHR will present two radar sensors for navigation support of drones. The sensors are valuable components in the implementation of autonomous flying drones: they function as obstacle detectors to prevent collisions. Radar sensors also operate reliably in restricted visibility, e.g. in foggy or dusty conditions. Due to their ability to measure distances with high precision, the radar sensors can also be used as altimeters when other sources of information such as barometers or GPS are not available or cannot operate optimally.

Drones play an increasingly important role in the area of logistics and services. Well-known logistic companies place great hope in these compact, aerial...

All Focus news of the innovation-report >>>



Industry & Economy
Event News

Ultrafast Wireless and Chip Design at the DATE Conference in Dresden

16.03.2018 | Event News

International Tinnitus Conference of the Tinnitus Research Initiative in Regensburg

13.03.2018 | Event News

International Virtual Reality Conference “IEEE VR 2018” comes to Reutlingen, Germany

08.03.2018 | Event News

Latest News

Wandering greenhouse gas

16.03.2018 | Earth Sciences

'Frequency combs' ID chemicals within the mid-infrared spectral region

16.03.2018 | Physics and Astronomy

Biologists unravel another mystery of what makes DNA go 'loopy'

16.03.2018 | Life Sciences

Science & Research
Overview of more VideoLinks >>>