Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Simulated Digestion

27.04.2012
Nanomaterial made from lipids and silicon dioxide improves absorption of pharmaceuticals

Some medicines have to be taken either before, after, or during a meal because food ingredients can affect its absorption or bioavailability. Australian researchers have now encapsulated drugs in a matrix of silicon dioxide and lipids to simulate the administration of pharmaceuticals with food.



As the researchers report in the journal Angewandte Chemie, drug absorption is increased through control of the enzymatic digestion of the lipid droplets.

For example, the body only absorbs fat-soluble vitamins A and D in the presence of some fat. Also, the bioavailability of many poorly water-soluble drugs increases when they are taken with high-fat meals. There are many techniques for the lipid-based delivery of pharmaceuticals, including emulsions, micelles and “packaging” in liposomes. These methods prevent the active ingredients from precipitating out and improve transportation to the absorption sites in the gastrointestinal tract. However, in order for the drug to become active in the body, it must be released from its lipid shell. The enzymatic decomposition of the lipid coating plays an important role in this process, but it has proven to be difficult to control. In addition, it is difficult to calculate the extent to which such lipid “packaging” really increases the bioavailability of a drug.

Clive Prestidge and a team at the University of South Australia and Monash University have now developed a controllable packaging type. Their material consists of a nanostructured network of silicon dioxide nanoparticles that contains nanoscopic lipid droplets containing the drug. This system is produced by generating a fine emulsion of the drug-containing oil droplets in an aqueous phase. The silicon dioxide particles collect around the droplets at the phase boundary. Spray-drying results in solid microparticles of entrapped lipid droplets.

The team has demonstrated that the lipid in these microparticles is enzymatically digested much more rapidly than pure lipid drops. This is because the nanostructured silicon dioxide network holds the enzymes close to their substrate. The size of the silicon dioxide particles used and the porosity of the resulting matrix determine how fast the enzymatic decomposition of the lipids occurs.

Animal trials with Celecoxib, a drug used to treat arthritis, showed a higher drug content in plasma when the pharmaceutical was orally administered in this new form rather than in its pure state or as drug-containing lipid drops. In contrast to Celecoxib-containing lipid drops, the release rate did not vary from batch to batch or after a longer storage period.

The new nanomaterial imitates the food effect in a predictable fashion and allows for better control of drug release, it could minimise the food effect on drug absorption and enhance more predictable therapeutic responses.

About the Author
Dr Clive Prestidge is the Professor of Colloid and Pharmaceutical Science at the University of South Australia and Associate Director for Nanomedicine at the Ian Wark Research Institute. His research group focuses on nanomaterials for pharmaceutical delivery. As a result, Prestidge filed number of patents and established a company named Cerida, for which he serves as Chief Technical Officer.
Author: Clive A. Prestidge, University of South Australia, Mawson Lakes (Australia), http://unisa.edu.au/iwri/staffpages/cliveprestidge.asp
Title: Hybrid Nanomaterials that Mimic the Food Effect: Controlling Enzymatic Digestion for Enhanced Oral Drug Absorption

Angewandte Chemie International Edition, Permalink to the article: http://dx.doi.org/10.1002/anie.201200409

Clive A. Prestidge | Angewandte Chemie
Further information:
http://pressroom.angewandte.org

More articles from Life Sciences:

nachricht BigH1 -- The key histone for male fertility
14.12.2017 | Institute for Research in Biomedicine (IRB Barcelona)

nachricht Guardians of the Gate
14.12.2017 | Max-Planck-Institut für Biochemie

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Long-lived storage of a photonic qubit for worldwide teleportation

MPQ scientists achieve long storage times for photonic quantum bits which break the lower bound for direct teleportation in a global quantum network.

Concerning the development of quantum memories for the realization of global quantum networks, scientists of the Quantum Dynamics Division led by Professor...

Im Focus: Electromagnetic water cloak eliminates drag and wake

Detailed calculations show water cloaks are feasible with today's technology

Researchers have developed a water cloaking concept based on electromagnetic forces that could eliminate an object's wake, greatly reducing its drag while...

Im Focus: Scientists channel graphene to understand filtration and ion transport into cells

Tiny pores at a cell's entryway act as miniature bouncers, letting in some electrically charged atoms--ions--but blocking others. Operating as exquisitely sensitive filters, these "ion channels" play a critical role in biological functions such as muscle contraction and the firing of brain cells.

To rapidly transport the right ions through the cell membrane, the tiny channels rely on a complex interplay between the ions and surrounding molecules,...

Im Focus: Towards data storage at the single molecule level

The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecule’s storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters.

Over the past few years, the building blocks of storage media have gotten ever smaller. But further miniaturization of the current technology is hindered by...

Im Focus: Successful Mechanical Testing of Nanowires

With innovative experiments, researchers at the Helmholtz-Zentrums Geesthacht and the Technical University Hamburg unravel why tiny metallic structures are extremely strong

Light-weight and simultaneously strong – porous metallic nanomaterials promise interesting applications as, for instance, for future aeroplanes with enhanced...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

See, understand and experience the work of the future

11.12.2017 | Event News

Innovative strategies to tackle parasitic worms

08.12.2017 | Event News

AKL’18: The opportunities and challenges of digitalization in the laser industry

07.12.2017 | Event News

 
Latest News

Plasmonic biosensors enable development of new easy-to-use health tests

14.12.2017 | Health and Medicine

New type of smart windows use liquid to switch from clear to reflective

14.12.2017 | Physics and Astronomy

BigH1 -- The key histone for male fertility

14.12.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>