These are the findings of a study by Dr. Friederike Klempin, Daniel Beis and Dr. Natalia Alenina from the research group led by Professor Michael Bader at the Max Delbrück Center (MDC) Berlin-Buch. Surprisingly, mice lacking brain serotonin due to a genetic mutation exhibited normal baseline neurogenesis. However, in these serotonin-deficient mice, activity-induced proliferation was impaired, and wheel running did not induce increased generation of new neurons. (Journal of Neuroscience, Doi:10.1523/JNEUROSCI.5855-12.2013)*.
(Photo: Friederike Klempin and Daniel Beis/ Copyright: MDC)
In wheel-running mice, the number of proliferating cells (red) that become neurons (green) in the hippocampus is increased, provided they have serotonin (left). In mice that due to a genetic mutation cannot produce serotonin, the number of proliferating cells is not increased following exercise (right).
(Photo: Friederike Klempin/ Copyright: MDC)
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