Current sequencing methods have a variety of advantages and disadvantages--including the cost involved. Dr Steven Jones and colleagues at UBC, the BC Cancer Agency and Simon Fraser University have combined cutting edge hardware with novel software to compile genome sequences at a fraction of the cost of previous methods.
The technique is outlined in the current issue of the journal Genome Biology.
Using the new approach, the research team--which also includes UBC's Joerg Bohlmann, Colette Breuil and Richard Hamelin--has compiled the first complete genome sequence of a fungus (Grosmannia clavigera) that is key to the mountain pine beetle infestation process.
“The key to better preparedness for future forest health crises such as the current mountain pine beetle epidemic lies in better understanding of the three main players–the trees, the bark beetles and a fungus–and their complex interactions,” said Bohlmann, Distinguished University Scholar and professor at UBC’s Michael Smith Laboratories.
“The infestation has affected 10 to 14 million hectares of pine forests in British Columbia. We can’t fight an enemy if we don’t know what it’s made of. The complete genome of the fungus brings us one step closer to winning the battle."
By triggering and overwhelming the trees’ defence mechanism, the fungus weakens the trees and creates an ideal environment for beetles to nest. It also stains the wood blue in the process, making the MPB-affected wood less marketable.
“This study has much wider research implications. What we learned from assembling the draft sequence of a fungus, we can now apply to sequencing human genomes,” says Jones, Head of Bioinfomatics at the BC Cancer Agency’s Genome Sciences Centre. “We're now using this novel approach to decode cancer tumours.”
“The ability to combine molecular biology techniques and computational approaches in this way really helps establish British Columbia as one of the leading jurisdictions in genome science.”
The research was partially funded by Genome BC, the Natural Sciences and Engineering Research Council of Canada, the British Columbia Ministry of Forests, the Natural Resources Canada Genomics program, and the BC Cancer Foundation.
Multi-institutional collaboration uncovers how molecular machines assemble
02.12.2016 | Salk Institute
Fertilized egg cells trigger and monitor loss of sperm’s epigenetic memory
02.12.2016 | IMBA - Institut für Molekulare Biotechnologie der Österreichischen Akademie der Wissenschaften GmbH
A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.
Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...
In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.
“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...
The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.
The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...
Broadband rotational spectroscopy unravels structural reshaping of isolated molecules in the gas phase to accommodate water
In two recent publications in the Journal of Chemical Physics and in the Journal of Physical Chemistry Letters, researchers around Melanie Schnell from the Max...
The efficiency of power electronic systems is not solely dependent on electrical efficiency but also on weight, for example, in mobile systems. When the weight of relevant components and devices in airplanes, for instance, is reduced, fuel savings can be achieved and correspondingly greenhouse gas emissions decreased. New materials and components based on gallium nitride (GaN) can help to reduce weight and increase the efficiency. With these new materials, power electronic switches can be operated at higher switching frequency, resulting in higher power density and lower material costs.
Researchers at the Fraunhofer Institute for Solar Energy Systems ISE together with partners have investigated how these materials can be used to make power...
16.11.2016 | Event News
01.11.2016 | Event News
14.10.2016 | Event News
02.12.2016 | Medical Engineering
02.12.2016 | Agricultural and Forestry Science
02.12.2016 | Physics and Astronomy