Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Sensor biochips could aid in cancer diagnosis and treatment

22.10.2009
Munich researchers develop new test process for cancer drugs

It is very difficult to predict whether a cancer drug will help an individual patient: only around one third of drugs will work directly in a given patient.

Researchers at the Heinz Nixdorf Chair for Medical Electronics at the Technische Universitaet Muenchen (TUM) have developed a new test process for cancer drugs. With the help of microchips, they can establish in the laboratory whether a patient's tumor cells will react to a given drug. This chip could help in future with the rapid identification of the most effective medication for the individual patient.

Cancer is the second most common cause of death in the Western world. According to the German Cancer Research Center in Heidelberg, approximately 450,000 people develop cancer every year in Germany. Although the doctors who treat cancer have numerous cancer drugs at their disposal today, the treatment must be precisely tailored to the patient and the type of cancer in question to be as effective as possible. If it takes a second or third try to find a drug that works, the patient loses valuable time in which the tumor can continue to grow.

In the future, miniature laboratories could provide the fast help required here. A lab-on-a-chip is a device -- made of glass, for example -- that is just a few millimeters across and has bioelectronic sensors that monitor the vitality of living cells. The chips sit in small wells, known as microtiter plates, and are covered with a patient's tumor cells. A robot changes the culture fluid in each well containing a chip at intervals of just a few minutes. The microsensors on the chip record, among other things, changes in the acid content of the medium and the cells' oxygen consumption; photographs of the process are also taken by a microscope fitted underneath the microtiter plate. All of the data merge in a computer that is connected to the system, and which provides an overview of the metabolic activity of the tumor cells and their vitality.

The robots and microtiter plates are kept in a chamber which, through precisely regulated temperature and humidity, provides an environment similar to that of the human body, and which also protects the tumor cells against external influences that can falsify the test results.

After the tumor cells have been able to divide undisturbed for a few hours, the robot applies an anti-cancer substance. If their metabolic activity declines over the next day or two, the active substance was able to kill the tumor cells and the drug is effective. Using the microchips, twenty-four active substances or combinations of active substances can be tested simultaneously in this way.

The gain in time for the patient is not the only positive factor here. Dr. Helmut Grothe, a scientist from the Heinz Nixdorf Chair at the TUM, explains: "Treatment with an ineffective cancer drug sometimes leads to the development of resistance to other drugs in the patient." Such resistance on the part of the tumor cells can also be identified at an early stage with the help of the sensor chip.

Another advantage of the system is its automation. The robot works faster and more accurately than any human could. Hence, the test results can be obtained quickly, which, in turn, saves on costs. Furthermore, the possibility of testing tumor cells with several active substances simultaneously facilitates the search for effective substances for individually tailored cancer treatment. Pharmaceutical companies may also be able to use the sensor chip in the development of new drugs in future.

As part of another research project, the scientists at the Heinz Nixdorf Chair are also developing a sensor chip that is intended to control tumor growth. The chip, which would be implanted once in the vicinity of the tumor, could release cancer drugs or pain medication only when the tumor grows. The release of the active substances would be controlled by electrical impulses. This sensor system could be used in the treatment of inoperable tumors, for example pancreatic tumors.

In the past, microchips have also been developed at the TUM's Heinz Nixdorf Chair for use in other research fields. For example, one such system is used in the analysis of the water quality of streams and rivers. In this case, a small pump removes samples at regular intervals from the water body and channels it via a pipe to a sensor chip on which algae have been planted. As algae are highly sensitive to toxic substances, they are particularly suitable for water analysis and react to the minutest impurities: their metabolic activity, which is measured on the basis of their oxygen production, declines in less than one minute in the presence of toxins. The data recorded by this sensor system are transmitted via mobile telephone to a computer that raises the alarm. The TUM research team won the E.ON Environmental Award, presented by the Bavarian energy company of the same name, for this system in 2008.

Contact:
Dr.-Ing. Helmut Grothe
Head of Technology Development
Heinz-Nixdorf Chair for Medical Electronics
Technische Universitaet Muenchen
Tel: +49.89.289.22949
E-mail: grothe@tum.de

Markus Bernards | EurekAlert!
Further information:
http://portal.mytum.de

More articles from Life Sciences:

nachricht Nanoparticle Exposure Can Awaken Dormant Viruses in the Lungs
16.01.2017 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt

nachricht Cholera bacteria infect more effectively with a simple twist of shape
13.01.2017 | Princeton University

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

Im Focus: Studying fundamental particles in materials

Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales

Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...

Im Focus: Designing Architecture with Solar Building Envelopes

Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.

As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...

Im Focus: How to inflate a hardened concrete shell with a weight of 80 t

At TU Wien, an alternative for resource intensive formwork for the construction of concrete domes was developed. It is now used in a test dome for the Austrian Federal Railways Infrastructure (ÖBB Infrastruktur).

Concrete shells are efficient structures, but not very resource efficient. The formwork for the construction of concrete domes alone requires a high amount of...

Im Focus: Bacterial Pac Man molecule snaps at sugar

Many pathogens use certain sugar compounds from their host to help conceal themselves against the immune system. Scientists at the University of Bonn have now, in cooperation with researchers at the University of York in the United Kingdom, analyzed the dynamics of a bacterial molecule that is involved in this process. They demonstrate that the protein grabs onto the sugar molecule with a Pac Man-like chewing motion and holds it until it can be used. Their results could help design therapeutics that could make the protein poorer at grabbing and holding and hence compromise the pathogen in the host. The study has now been published in “Biophysical Journal”.

The cells of the mouth, nose and intestinal mucosa produce large quantities of a chemical called sialic acid. Many bacteria possess a special transport system...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

Nothing will happen without batteries making it happen!

05.01.2017 | Event News

 
Latest News

Water - as the underlying driver of the Earth’s carbon cycle

17.01.2017 | Earth Sciences

Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

17.01.2017 | Materials Sciences

Smart homes will “LISTEN” to your voice

17.01.2017 | Architecture and Construction

VideoLinks
B2B-VideoLinks
More VideoLinks >>>