Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Scripps Florida scientists find genetic mutations linked to salivary gland tumors

29.07.2014

The findings may point the way to new cancer treatments

Research conducted at the Florida campus of The Scripps Research Institute (TSRI) has discovered links between a set of genes known to promote tumor growth and mucoepidermoid carcinoma, an oral cancer that affects the salivary glands.

The discovery could help physicians develop new treatments that target the cancer's underlying genetic causes.

The research, recently published online ahead of print by the Proceedings of the National Academy of Sciences, shows that a pair of proteins joined together by a genetic mutation—known as CRTC1/MAML2 (C1/M2)—work with MYC, a protein commonly associated with other cancers, to promote the oral cancer's growth and spread.

"This research provides new insights into the molecular mechanisms of these malignances and points to a new direction for potential therapies," says TSRI biologist Michael Conkright, PhD, who led the study.

The C1/M2 protein is created when the genes encoding CRTC1 and MAML2 mutate into a single gene through a process known as chromosomal translocation.

Such mutant "chimera" genes are linked to the formation of several forms of cancer. The team discovered that the C1/M2 protein further activates genetic pathways regulated by MYC, in addition to CREB, to begin a series of cellular changes leading to the development of mucoepidermoid carcinoma.

"The identification of unique interactions between C1/M2 and MYC suggests that drugs capable of disrupting these interactions may have therapeutic potential in the treatment of mucoepidermoid carcinomas, " said Antonio L. Amelio, Ph.D., first author of the study who is now assistant professor with the UNC School of Dentistry and member of the UNC Lineberger Comprehensive Cancer Center.

Researchers have known about the role of C1/M2 and its interactions with another protein, CREB, in the development of mucoepidermoid carcinoma, and physicians screen patients for the presence of the C1/M2 protein when testing for this cancer.

These new findings deepen the understanding of C1/M2's role by revealing that it works with a family of cancer-associated genes known as the MYC family to drive the cellular changes necessary for a tumor to develop.

The discovery of these new protein interactions may also reveal insights into the mechanisms behind other cancers that arise due to other genetic mutations involving the CREB and MYC pathways.

###

In addition to Conkright and Amelio, other authors of the study, "CRTC1/MAML2 gain-of-function interactions with MYC create a gene signature predictive of cancers with CREB–MYC involvement," include Mohammad Fallahi of IT Informatics, Franz X. Schaub, Mariam B. Lawani, Adam S. Alperstein, Mark R. Southern, Brandon M. Young, and John L. Cleveland of TSRI, and Min Zhang, Lizi Wu, Maria Zajac-Kaye, and Frederic J. Kaye of Shands Cancer Center, University of Florida (Gainsville).

The research was supported in part by a Howard Temin Pathway to Independence Award in Cancer Research from the National Cancer Institute (NCI) (K99-CA157954), National Institutes of Health/NCI R01 Grant CA100603, a PGA National WCAD Cancer Research Fellowship and Ruth L. Kirschstein National Research Service Award from the National Cancer Institute (F32-CA134121), the Margaret Q. Landerberger Research Foundation, a Swiss National Foundation Postdoctoral Fellowship and monies from the State of Florida to TSRI's Scripps Florida.

Eric Sauter | Eurek Alert!
Further information:
http://www.scripps.edu

Further reports about: CREB Cancer TSRI carcinoma genes gland interactions mechanisms mutations pathways salivary tumors

More articles from Life Sciences:

nachricht Identifying drug targets for leukaemia
02.05.2016 | The Hong Kong Polytechnic University

nachricht A cell senses its own curves: New research from the MBL Whitman Center
29.04.2016 | Marine Biological Laboratory

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: 2+1 is Not Always 3 - In the microworld unity is not always strength

If a person pushes a broken-down car alone, there is a certain effect. If another person helps, the result is the sum of their efforts. If two micro-particles are pushing another microparticle, however, the resulting effect may not necessarily be the sum their efforts. A recent study published in Nature Communications, measured this odd effect that scientists call “many body.”

In the microscopic world, where the modern miniaturized machines at the new frontiers of technology operate, as long as we are in the presence of two...

Im Focus: Tiny microbots that can clean up water

Researchers from the Max Planck Institute Stuttgart have developed self-propelled tiny ‘microbots’ that can remove lead or organic pollution from contaminated water.

Working with colleagues in Barcelona and Singapore, Samuel Sánchez’s group used graphene oxide to make their microscale motors, which are able to adsorb lead...

Im Focus: ORNL researchers discover new state of water molecule

Neutron scattering and computational modeling have revealed unique and unexpected behavior of water molecules under extreme confinement that is unmatched by any known gas, liquid or solid states.

In a paper published in Physical Review Letters, researchers at the Department of Energy's Oak Ridge National Laboratory describe a new tunneling state of...

Im Focus: Bionic Lightweight Design researchers of the Alfred Wegener Institute at Hannover Messe 2016

Honeycomb structures as the basic building block for industrial applications presented using holo pyramid

Researchers of the Alfred Wegener Institute (AWI) will introduce their latest developments in the field of bionic lightweight design at Hannover Messe from 25...

Im Focus: New world record for fullerene-free polymer solar cells

Polymer solar cells can be even cheaper and more reliable thanks to a breakthrough by scientists at Linköping University and the Chinese Academy of Sciences (CAS). This work is about avoiding costly and unstable fullerenes.

Polymer solar cells can be even cheaper and more reliable thanks to a breakthrough by scientists at Linköping University and the Chinese Academy of Sciences...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

The “AC21 International Forum 2016” is About to Begin

27.04.2016 | Event News

Soft switching combines efficiency and improved electro-magnetic compatibility

15.04.2016 | Event News

Grid-Supportive Buildings Give Boost to Renewable Energy Integration

12.04.2016 | Event News

 
Latest News

Identifying drug targets for leukaemia

02.05.2016 | Life Sciences

Clay nanotube-biopolymer composite scaffolds for tissue engineering

02.05.2016 | Materials Sciences

NASA's Fermi Telescope helps link cosmic neutrino to blazar blast

02.05.2016 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>