Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


Scientists test a Nanoparticle “Alarm Clock” to Awaken Immune Systems Put to Sleep by Cancer


Researchers at Dartmouth-Hitchcock Norris Cotton Cancer Center are exploring ways to wake up the immune system so it recognizes and attacks invading cancer cells. Tumors protect themselves by tricking the immune system into accepting everything as normal, even while cancer cells are dividing and spreading.

One pioneering approach, discussed in a review article published this week in WIREs Nanomedicine and Nanobiotechnology, uses nanoparticles to jumpstart the body’s ability to fight tumors. Nanoparticles are too small to imagine. One billion could fit on the head of a pin.

A nanoparticle lab at Dartmouth's Geisel School of Medicine

This makes them stealthy enough to penetrate cancer cells with therapeutic agents such as antibodies, drugs, vaccine type viruses, or even metallic particles. Though small, nanoparticles can pack large payloads of a variety of agents that have different effects that activate and strengthen the body’s immune system response against tumors.

There is an expanding array of nanoparticle types being developed and tested for cancer therapy. They are primarily being used to package and deliver the current generation of cancer cell killing drugs and progress is being made in that effort.

“Our lab’s approach differs from most in that we use nanoparticles to stimulate the immune system to attack tumors and there are a variety of potential ways that can be done,” said Steve Fiering, PhD, Norris Cotton Cancer Center researcher and professor of Microbiology and Immunology, and of Genetics at the Geisel School of Medicine at Dartmouth. “Perhaps the most exciting potential of nanoparticles is that although very small, they can combine multiple therapeutic agents.”

The immune therapy methods limit a tumor’s ability to trick the immune system. It helps it to recognize the threat and equip it to effectively attack the tumor with more “soldier” cells. These approaches are still early in development in the laboratory or clinical trials.

“Now that efforts to stimulate anti-tumor immune responses are moving from the lab to the clinic, the potential for nanoparticles to be utilized to improve an immune-based therapy approach is attracting a lot of attention from both scientists and clinicians. And clinical usage does not appear too distant,” said Fiering.

Fiering is testing the use of heat in combination with nanoparticles. An inactive metallic nanoparticle containing iron, silver, or gold is absorbed by a cancer cell. Then the nanoparticle is activated using magnetic energy, infrared light, or radio waves. The interaction creates heat that kills cancer cells.

The heat, when precisely applied, can prompt the immune system to kill cancer cells that have not been heated. The key to this approach is minimizing healthy tissue damage while maximizing cancerous tumor destruction of the sort that improves recognition of the tumor by the immune system.

Fiering cautions that there is a great deal of research and many technical variables that should be explored to find the most effective ways to use nanoparticles to heat tumors and stimulate anti-tumor immunity.

According to Fiering, this approach is far from new, “The use of heat to treat cancer was first recorded by ancient Egyptians. But has reemerged with high tech modern systems as a contributor to the new paradigm of fighting cancer with the patients’ own immune system.”

About Norris Cotton Cancer Center at Dartmouth-Hitchcock
Norris Cotton Cancer Center combines advanced cancer research at Dartmouth and the Geisel School of Medicine with patient-centered cancer care provided at Dartmouth-Hitchcock Medical Center, at Dartmouth-Hitchcock regional locations in Manchester, Nashua, and Keene, NH, and St. Johnsbury, VT, and at 12 partner hospitals throughout New Hampshire and Vermont. It is one of 41 centers nationwide to earn the National Cancer Institute’s “Comprehensive Cancer Center” designation. Learn more about Norris Cotton Cancer Center research, programs, and clinical trials online at

Donna Dubuc | newswise

Further reports about: Cancer Medicine ability attack heat immune nanoparticle stimulate tumors

More articles from Life Sciences:

nachricht Flipping molecular attachments amps up activity of CO2 catalyst
06.10.2015 | DOE/Brookhaven National Laboratory

nachricht Safe nanomotors propelled by sugar
06.10.2015 | Max-Planck-Institut für Intelligente Systeme

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Physicists shrink particle accelerator

Prototype demonstrates feasibility of building terahertz accelerators

An interdisciplinary team of researchers has built the first prototype of a miniature particle accelerator that uses terahertz radiation instead of radio...

Im Focus: Simple detection of magnetic skyrmions

New physical effect: researchers discover a change of electrical resistance in magnetic whirls

At present, tiny magnetic whirls – so called skyrmions – are discussed as promising candidates for bits in future robust and compact data storage devices. At...

Im Focus: High-speed march through a layer of graphene

In cooperation with the Center for Nano-Optics of Georgia State University in Atlanta (USA), scientists of the Laboratory for Attosecond Physics of the Max Planck Institute of Quantum Optics and the Ludwig-Maximilians-Universität have made simulations of the processes that happen when a layer of carbon atoms is irradiated with strong laser light.

Electrons hit by strong laser pulses change their location on ultrashort timescales, i.e. within a couple of attoseconds (1 as = 10 to the minus 18 sec). In...

Im Focus: Battery Production: Laser Light instead of Oven-Drying and Vacuum Technology

At the exhibition BATTERY + STORAGE as part of WORLD OF ENERGY SOLUTIONS 2015 in Stuttgart, the Fraunhofer Institutes for Laser Technology ILT and for Ceramic Technologies and Systems IKTS will be showing how laser technology can be used to manufacture batteries both cost- and energy-efficiently.

In the truest sense, it’s all about watts at the Dresden-based Fraunhofer Institute for Ceramic Technologies and Systems IKTS and the Aachen-based Fraunhofer...

Im Focus: New Sinumerik features improve productivity and precision

EMO 2015, Hall 3, Booth E06/F03

  • Drive optimization called automatically by the part program boosts productivity
  • Automatically switching the dynamic values to rapid traverse and interpolation...
All Focus news of the innovation-report >>>



Event News

EHFG 2015: Securing healthcare and sustainably strengthening healthcare systems

01.10.2015 | Event News

Conference in Brussels: Tracking and Tracing the Smallest Marine Life Forms

30.09.2015 | Event News

World Alzheimer`s Day – Professor Willnow: Clearer Insights into the Development of the Disease

17.09.2015 | Event News

Latest News

Graphene teams up with two-dimensional crystals for faster data communications

06.10.2015 | Information Technology

Laser-wielding physicists seize control of atoms' behavior

06.10.2015 | Physics and Astronomy

Flipping molecular attachments amps up activity of CO2 catalyst

06.10.2015 | Life Sciences

More VideoLinks >>>