Scientists Teach Cultured Brain Cells to Keep Time
The ability to tell time is fundamental to how humans interact with each other and the world. Timing plays an important role, for example, in our ability to recognize speech patterns and to create music.
Patterns are an essential part of timing. The human brain easily learns patterns, allowing us to recognize familiar patterns of shapes, like faces, and timed patterns, like the rhythm of a song. But exactly how the brain keeps time and learns patterns remains a mystery.
In this three-year study, UCLA scientists attempted to unravel the mystery by testing whether networks of brain cells kept alive in culture could be “trained” to keep time. The team stimulated the cells with simple patterns – two stimuli separated by different intervals lasting from a twentieth of a second up to half a second.
After two hours of training, the team observed a measurable change in the cellular networks’ response to a single input. In the networks trained with a short interval, the network’s activity lasted for a short period of time. Conversely, in the networks trained with a long interval, network activity lasted for a longer amount of time.
The UCLA findings are the first to suggest that networks of brain cells in a petri dish can learn to generate simple timed intervals. The research sheds light on how the brain tells time and will enhance scientists’ understanding of how the brain works.
Dean Buonomano, professor of neurobiology and psychology at UCLA’s David Geffen School of Medicine and Brain Research Institute, is available for interviews.
A color image showing cell-network response time is available upon request.
The research appears in the June 13 edition of Nature Neuroscience, now online at http://www.nature.com/neuro/journal/vaop/ncurrent/full/nn.2579.html.
The study was supported by a grant from the National Institute of Mental Health.
Elaine Schmidt | Newswise Science News
The most recent press releases about innovation >>>
Die letzten 5 Focus-News des innovations-reports im Überblick:
New technique promises tunable laser devices
Whispering gallery mode (WGM) resonators are used to make tiny micro-lasers, sensors, switches, routers and other devices. These tiny structures rely on a...
Using ultrafast flashes of laser and x-ray radiation, scientists at the Max Planck Institute of Quantum Optics (Garching, Germany) took snapshots of the briefest electron motion inside a solid material to date. The electron motion lasted only 750 billionths of the billionth of a second before it fainted, setting a new record of human capability to capture ultrafast processes inside solids!
When x-rays shine onto solid materials or large molecules, an electron is pushed away from its original place near the nucleus of the atom, leaving a hole...
For the first time, physicists have successfully imaged spiral magnetic ordering in a multiferroic material. These materials are considered highly promising candidates for future data storage media. The researchers were able to prove their findings using unique quantum sensors that were developed at Basel University and that can analyze electromagnetic fields on the nanometer scale. The results – obtained by scientists from the University of Basel’s Department of Physics, the Swiss Nanoscience Institute, the University of Montpellier and several laboratories from University Paris-Saclay – were recently published in the journal Nature.
Multiferroics are materials that simultaneously react to electric and magnetic fields. These two properties are rarely found together, and their combined...
MBM ScienceBridge GmbH successfully negotiated a license agreement between University Medical Center Göttingen (UMG) and the biotech company Tissue Systems Holding GmbH about commercial use of a multi-well tissue plate for automated and reliable tissue engineering & drug testing.
MBM ScienceBridge GmbH successfully negotiated a license agreement between University Medical Center Göttingen (UMG) and the biotech company Tissue Systems...
HZI researchers pave the way for new agents that render hospital pathogens mute
Pathogenic bacteria are becoming resistant to common antibiotics to an ever increasing degree. One of the most difficult germs is Pseudomonas aeruginosa, a...