Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Scientists at Scripps Research Develop Novel Technology to Identify Biomarkers for Ulcerative Colitis

04.10.2012
Scientists from the Florida campus of The Scripps Research Institute have developed a novel technology that can identify, in animal models, potential biomarkers of ulcerative colitis, a type of inflammatory bowel disease that affects the lining of the colon.
The study was published October 3, 2012, in the Journal of the American Chemical Society.

The new research focuses on the protein arginine deiminases (PAD), which have been implicated in a number of diseases, including cancer, multiple sclerosis and rheumatoid arthritis. PADs participate in reactions in the body that form the amino acid citrulline in proteins through a process known as citrullination. This modification can have significant effects on the structure and function of the modified proteins.

While abnormally high PAD activity is present in a host of human diseases, the exact role of citrullination in these diseases remains unknown, largely due to the lack of readily available chemical probes to study it.

¡°We have developed technology to identify biomarkers for a variety of diseases in which you see abnormal PAD activity,¡± said Paul Thompson, an associate professor in the Department of Chemistry at Scripps Research, who led the study. ¡°This identification of potential biomarkers in animal models of ulcerative colitis is really the first step in a much larger effort. We want to push forward into rheumatoid arthritis and cancer to look for different diagnostic markers in these disease situations.¡±

In the new study, the scientists describe a chemical probe called rhodamine©phenylglyoxal (Rh©PG), which tags citrulline-containing proteins with a fluorescent imaging compound.

According to Thompson, the next step will be to produce further generations of this chemical probe to isolate the biomarker proteins and determine their sites of modification, as well as to quantify the extent of the citrullination.

The first author of the study, ¡°Seeing Citrulline: Development of a Phenylglyoxal©Based Probe to Visualize Protein Citrullination,¡± is Kevin L. Bicker of Scripps Research. Other authors include Venkataraman Subramanian of Scripps Research and Alexander A. Chumanevich and Lorne J. Hofseth of the University of South Carolina. For more information, see http://pubs.acs.org/doi/abs/10.1021/ja308871v

The study was supported by the National Institutes of Health (grants GM079357 and CA151304) and Scripps Research.

About The Scripps Research Institute

The Scripps Research Institute is one of the world's largest independent, not-for-profit organizations focusing on research in the biomedical sciences. Over the past decades, Scripps Research has developed a lengthy track record of major contributions to science and health, including laying the foundation for new treatments for cancer, rheumatoid arthritis, hemophilia, and other diseases. The institute employs about 3,000 people on its campuses in La Jolla, CA, and Jupiter, FL, where its renowned scientists¡ªincluding three Nobel laureates¡ªwork toward their next discoveries. The institute's graduate program, which awards Ph.D. degrees in biology and chemistry, ranks among the top ten of its kind in the nation. For more information, see www.scripps.edu.
For information:
Office of Communications
Tel: 858-784-8134
Fax: 858-784-8136
press@scripps.edu

Eric Sauter | EurekAlert!
Further information:
http://www.scripps.edu

More articles from Life Sciences:

nachricht Building a brain, cell by cell: Researchers make a mini neuron network (of two)
23.05.2018 | Institute of Industrial Science, The University of Tokyo

nachricht Research reveals how order first appears in liquid crystals
23.05.2018 | Brown University

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: LZH showcases laser material processing of tomorrow at the LASYS 2018

At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.

At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...

Im Focus: Self-illuminating pixels for a new display generation

There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?

At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...

Im Focus: Explanation for puzzling quantum oscillations has been found

So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics

Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...

Im Focus: Dozens of binaries from Milky Way's globular clusters could be detectable by LISA

Next-generation gravitational wave detector in space will complement LIGO on Earth

The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...

Im Focus: Entangled atoms shine in unison

A team led by Austrian experimental physicist Rainer Blatt has succeeded in characterizing the quantum entanglement of two spatially separated atoms by observing their light emission. This fundamental demonstration could lead to the development of highly sensitive optical gradiometers for the precise measurement of the gravitational field or the earth's magnetic field.

The age of quantum technology has long been heralded. Decades of research into the quantum world have led to the development of methods that make it possible...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Save the date: Forum European Neuroscience – 07-11 July 2018 in Berlin, Germany

02.05.2018 | Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

Unique scope of UV LED technologies and applications presented in Berlin: ICULTA-2018

12.04.2018 | Event News

 
Latest News

Research reveals how order first appears in liquid crystals

23.05.2018 | Life Sciences

Space-like gravity weakens biochemical signals in muscle formation

23.05.2018 | Life Sciences

NIST puts the optical microscope under the microscope to achieve atomic accuracy

23.05.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>