The work is led by Dr. Christopher Nomura of the college’s Department of Chemistry, who discovered that a simple protein molecule can interrupt the process bacteria use to move, eat, attach to surfaces, and communicate with one another or, in other words, to become potentially harmful.
“This is fundamentally a new way to think about blocking bacteria from becoming virulent,” Nomura said.
Exposing bacteria to the synthetic protein disrupts the developmental sequence that is common among such organisms, he said. This gives the process the potential to work against an array of bacteria including those that threaten patients with certain illnesses, such as cystic fibrosis, stubborn strains that commonly affect hospital patients and strains that occur in desert environments and prove troublesome for U.S. troops serving in Afghanistan or similar arid environments.
The college is seeking to patent the process.
Nomura’s research group focuses on the synthesis and properties of eco-friendly, biologically based materials, in particular the production of biobased polymers that can be used to make biodegradable plastics. He and his postdoctoral researcher, Dr. Benjamin Lundgren, were working on experiments in that realm when they overproduced some proteins that they thought would increase the expression of genes to produce the bioplastic materials. But instead of making the bacteria produce large quantities of plastics, the protein had the opposite effect.
Nomura began to investigate the chemistry behind the startling development and discovered that specific proteins can attach themselves to the bacterial DNA in a manner that essentially prevents the organism from expressing the information contained within its genes and results in short circuiting the ability of bacteria to respond to changes in their environment.
The antimicrobial process has an added advantage over traditional antibiotics currently in use: It will be extremely difficult for bacteria to do an end run around the process by simply mutating. Since the protein targets hundreds of genes simultaneously, a corresponding mutation would also involve hundreds of changes. Traditional antibiotics attack only one aspect of the bacteria’s development, making mutation a simpler task.
“Basically, we’re interrupting the flow of genetic information in the cell, in effect ‘hacking’ the program of the bacterial cell,” Nomura said. “If we can fundamentally control the mechanism of gene expression, we can control what the bacteria are capable of doing. We can prevent them from becoming virulent.”
Claire B. Dunn | Newswise
27.05.2015 | Okinawa Institute of Science and Technology (OIST) Graduate University
Seeing the action
27.05.2015 | University of California - Santa Barbara
The only professorship in Germany to date, one master's programme, one laboratory with worldwide unique equipment and the corresponding research results: The University of Würzburg is leading in the field of biofabrication.
Paul Dalton is presently the only professor of biofabrication in Germany. About a year ago, the Australian researcher relocated to the Würzburg department for...
Physicists have developed an innovative method that could enable the efficient use of nanocomponents in electronic circuits. To achieve this, they have developed a layout in which a nanocomponent is connected to two electrical conductors, which uncouple the electrical signal in a highly efficient manner. The scientists at the Department of Physics and the Swiss Nanoscience Institute at the University of Basel have published their results in the scientific journal “Nature Communications” together with their colleagues from ETH Zurich.
Electronic components are becoming smaller and smaller. Components measuring just a few nanometers – the size of around ten atoms – are already being produced...
Development and implementation of an advanced automobile parking navigation platform for parking services
To fulfill the requirements of the industry, PolyU researchers developed the Advanced Automobile Parking Navigation Platform, which includes smart devices,...
The world's first electrical car and passenger ferry powered by batteries has entered service in Norway. The ferry only uses 150 kWh per route, which...
On Tuesday, 19 May 2015 the research icebreaker Polarstern will leave its home port in Bremerhaven, setting a course for the Arctic. Led by Dr Ilka Peeken from the Alfred Wegener Institute, Helmholtz Centre for Polar and Marine Research (AWI) a team of 53 researchers from 11 countries will investigate the effects of climate change in the Arctic, from the surface ice floes down to the seafloor.
RV Polarstern will enter the sea-ice zone north of Spitsbergen. Covering two shallow regions on their way to deeper waters, the scientists on board will focus...
20.05.2015 | Event News
18.05.2015 | Event News
12.05.2015 | Event News
27.05.2015 | Power and Electrical Engineering
27.05.2015 | Health and Medicine
27.05.2015 | Physics and Astronomy