The work is led by Dr. Christopher Nomura of the college’s Department of Chemistry, who discovered that a simple protein molecule can interrupt the process bacteria use to move, eat, attach to surfaces, and communicate with one another or, in other words, to become potentially harmful.
“This is fundamentally a new way to think about blocking bacteria from becoming virulent,” Nomura said.
Exposing bacteria to the synthetic protein disrupts the developmental sequence that is common among such organisms, he said. This gives the process the potential to work against an array of bacteria including those that threaten patients with certain illnesses, such as cystic fibrosis, stubborn strains that commonly affect hospital patients and strains that occur in desert environments and prove troublesome for U.S. troops serving in Afghanistan or similar arid environments.
The college is seeking to patent the process.
Nomura’s research group focuses on the synthesis and properties of eco-friendly, biologically based materials, in particular the production of biobased polymers that can be used to make biodegradable plastics. He and his postdoctoral researcher, Dr. Benjamin Lundgren, were working on experiments in that realm when they overproduced some proteins that they thought would increase the expression of genes to produce the bioplastic materials. But instead of making the bacteria produce large quantities of plastics, the protein had the opposite effect.
Nomura began to investigate the chemistry behind the startling development and discovered that specific proteins can attach themselves to the bacterial DNA in a manner that essentially prevents the organism from expressing the information contained within its genes and results in short circuiting the ability of bacteria to respond to changes in their environment.
The antimicrobial process has an added advantage over traditional antibiotics currently in use: It will be extremely difficult for bacteria to do an end run around the process by simply mutating. Since the protein targets hundreds of genes simultaneously, a corresponding mutation would also involve hundreds of changes. Traditional antibiotics attack only one aspect of the bacteria’s development, making mutation a simpler task.
“Basically, we’re interrupting the flow of genetic information in the cell, in effect ‘hacking’ the program of the bacterial cell,” Nomura said. “If we can fundamentally control the mechanism of gene expression, we can control what the bacteria are capable of doing. We can prevent them from becoming virulent.”
Claire B. Dunn | Newswise
New method opens crystal clear views of biomolecules
11.02.2016 | Deutsches Elektronen-Synchrotron DESY
Scientists from MIPT gain insights into 'forbidden' chemistry
11.02.2016 | Moscow Institute of Physics and Technology
Today, plants and microorganisms are heavily used for the production of medicinal products. The production of biopharmaceuticals in plants, also referred to as “Molecular Pharming”, represents a continuously growing field of plant biotechnology. Preferred host organisms include yeast and crop plants, such as maize and potato – plants with high demands. With the help of a special algal strain, the research team of Prof. Ralph Bock at the Max Planck Institute of Molecular Plant Physiology in Potsdam strives to develop a more efficient and resource-saving system for the production of medicines and vaccines. They tested its practicality by synthesizing a component of a potential AIDS vaccine.
The use of plants and microorganisms to produce pharmaceuticals is nothing new. In 1982, bacteria were genetically modified to produce human insulin, a drug...
Atomic clock experts from the Physikalisch-Technische Bundesanstalt (PTB) are the first research group in the world to have built an optical single-ion clock which attains an accuracy which had only been predicted theoretically so far. Their optical ytterbium clock achieved a relative systematic measurement uncertainty of 3 E-18. The results have been published in the current issue of the scientific journal "Physical Review Letters".
Atomic clock experts from the Physikalisch-Technische Bundesanstalt (PTB) are the first research group in the world to have built an optical single-ion clock...
The University of Würzburg has two new space projects in the pipeline which are concerned with the observation of planets and autonomous fault correction aboard satellites. The German Federal Ministry of Economic Affairs and Energy funds the projects with around 1.6 million euros.
Detecting tornadoes that sweep across Mars. Discovering meteors that fall to Earth. Investigating strange lightning that flashes from Earth's atmosphere into...
Physicists from Saarland University and the ESPCI in Paris have shown how liquids on solid surfaces can be made to slide over the surface a bit like a bobsleigh on ice. The key is to apply a coating at the boundary between the liquid and the surface that induces the liquid to slip. This results in an increase in the average flow velocity of the liquid and its throughput. This was demonstrated by studying the behaviour of droplets on surfaces with different coatings as they evolved into the equilibrium state. The results could prove useful in optimizing industrial processes, such as the extrusion of plastics.
The study has been published in the respected academic journal PNAS (Proceedings of the National Academy of Sciences of the United States of America).
Exceeding critical temperature limits in the Southern Ocean may cause the collapse of ice sheets and a sharp rise in sea levels
A future warming of the Southern Ocean caused by rising greenhouse gas concentrations in the atmosphere may severely disrupt the stability of the West...
09.02.2016 | Event News
02.02.2016 | Event News
26.01.2016 | Event News
11.02.2016 | Life Sciences
11.02.2016 | Physics and Astronomy
11.02.2016 | Earth Sciences