The research illustrates what may perhaps become an effective targeted epigenetic therapy in breast cancer. Interestingly, the targeted treatment showed exciting results in triple-negative breast cancer cells, reverting their function and appearance, and sensitizing them to tamoxifen and retinoids.
By introducing a small peptide, called the SID decoy, to interfere with protein binding in the Sin 3 PAH2 domain, scientists reduced the growth of triple-negative cancer cells by 80 percent. The decoy also blocked cancer cell invasion, which may shed light on preventing metastasis. The study was published in the June 29 print edition of the journal of the Proceedings of the National Academy of Sciences.
Triple-negative breast cancer is an aggressive form of breast cancer more commonly diagnosed in young women, African-American women and women with BRCA-1 mutated cancers, said medical oncologist Samuel Waxman, M.D., the study's senior author. Currently, the only treatment options that women with triple-negative breast cancer have are radiation therapy, surgery and chemotherapy. Women with triple-negative breast cancer do not respond to hormonal therapy or Herceptin and have a higher recurrence rate after chemotherapy.
"Hopefully, this breakthrough research means we can expand treatment options for women with triple-negative breast cancer and give them a chance at anti-estrogen hormonal therapy," said Dr. Waxman, a professor in the department of Hematology and Oncology at Mount Sinai Medical Center in New York City and the scientific director of the Samuel Waxman Cancer Research Foundation.
Arthur Zelent, Ph.D., a co-author of the study, said researchers plan to investigate small molecules that are predicted to have the same effect as the decoy peptide. "This could form the basis for a new class of targeted, epigenetic drugs in breast cancer," said Dr. Zelent, a team leader at The Institute of Cancer Research in the United Kingdom.
Elizabeth Woolfe, the executive director of the Triple Negative Breast Cancer Foundation, said though the study's results are too preliminary to make a clinical impact for cancer survivors today, she added, "The findings offer encouraging results that could lead to other promising research and the potential for new therapeutics for women facing triple-negative breast cancer."
About the Samuel Waxman Cancer Research Foundation
The Samuel Waxman Cancer Research Foundation is an international organization dedicated to curing and preventing cancer. The Foundation is a pioneer in cancer research, focusing on uncovering the causes of cancer and reprogramming cancer cells.
We dedicate ourselves to delivering tailored, minimally toxic treatments to patients. Our mission is to eradicate cancer by bridging the gap between lab science and the patient.
Through our collaborative group of world-class scientists, the Institute Without Walls, investigators share information and tools to speed the pace of cancer research. Since its inception in 1976, the SWCRF has awarded more than $70 million to support the work of more than 170 researchers across three continents.
Jenny Song | EurekAlert!
Rutgers scientists discover 'Legos of life'
23.01.2018 | Rutgers University
Researchers identify a protein that keeps metastatic breast cancer cells dormant
23.01.2018 | Institute for Research in Biomedicine (IRB Barcelona)
Physicists have developed a technique based on optical microscopy that can be used to create images of atoms on the nanoscale. In particular, the new method allows the imaging of quantum dots in a semiconductor chip. Together with colleagues from the University of Bochum, scientists from the University of Basel’s Department of Physics and the Swiss Nanoscience Institute reported the findings in the journal Nature Photonics.
Microscopes allow us to see structures that are otherwise invisible to the human eye. However, conventional optical microscopes cannot be used to image...
On the way to an intelligent laboratory, physicists from Innsbruck and Vienna present an artificial agent that autonomously designs quantum experiments. In initial experiments, the system has independently (re)discovered experimental techniques that are nowadays standard in modern quantum optical laboratories. This shows how machines could play a more creative role in research in the future.
We carry smartphones in our pockets, the streets are dotted with semi-autonomous cars, but in the research laboratory experiments are still being designed by...
What enables electrons to be transferred swiftly, for example during photosynthesis? An interdisciplinary team of researchers has worked out the details of how...
For the first time, scientists have precisely measured the effective electrical charge of a single molecule in solution. This fundamental insight of an SNSF Professor could also pave the way for future medical diagnostics.
Electrical charge is one of the key properties that allows molecules to interact. Life itself depends on this phenomenon: many biological processes involve...
At the JEC World Composite Show in Paris in March 2018, the Fraunhofer Institute for Laser Technology ILT will be focusing on the latest trends and innovations in laser machining of composites. Among other things, researchers at the booth shared with the Aachen Center for Integrative Lightweight Production (AZL) will demonstrate how lasers can be used for joining, structuring, cutting and drilling composite materials.
No other industry has attracted as much public attention to composite materials as the automotive industry, which along with the aerospace industry is a driver...
08.01.2018 | Event News
11.12.2017 | Event News
08.12.2017 | Event News
23.01.2018 | Life Sciences
23.01.2018 | Earth Sciences
23.01.2018 | Physics and Astronomy