Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Scientists Identify and Compare Yeast Genomes

24.06.2011
If you think yeast is most useful for beer and pizza crust, here’s something else to chew on: a team of U.S. researchers has identified and compared the genetic codes for all known species of yeasts closely related to bakers’ and brewers’ yeast.

This information, published in the Genetics Society of America’s new open-access journal, G3: Genes | Genomes | Genetics (http://www.g3journal.org), lays the foundation for future understanding of mutation and disease, as studies of yeasts often identify key genes and mechanisms of disease.

“We hope to learn to read the language of DNA and tell when mutations or differences will cause disease and when they will be advantageous,” said Chris Todd Hittinger, senior author of the work from the Department of Biochemistry and Molecular Genetics at the University of Colorado School of Medicine in Aurora, Colorado. “Providing a complete catalog of diversity among this group of species will allow us to quickly test which changes are responsible for which functions in the laboratory with a level of precision and efficiency not possible in other organisms.”

Using massively parallel next-generation DNA sequencing, the researchers determined the genome sequences, doubling the number of genes available for comparison, and identifying which genes changed in which species. They did this by segmenting each organism’s DNA into small pieces, and then computationally “reassembled” the pieces and compared them to the genome of S. cerevisiae (the species used to make beer, bread, wine, etc.) to identify similarities and differences. The researchers also genetically engineered several of the strains to make them amenable for experimentation. Results from this study will allow researchers to compare the genetics, molecular biology, and ecology of these species. Because yeast genomes and lifestyles are relatively simple, determining how diversity is encoded in their DNA is much easier than with more complex organisms, such as humans.

“The experimental resources described in this paper extend the value of yeasts for understanding biological processes,” said Brenda Andrews, Editor-in-Chief of G3: Genes | Genomes | Genetics, “and if they help us make better pizza crust and beer along the way, all the better.”

The Genetics Society of America established G3: Genes | Genomes |Genetics (http://www.g3journal.org) to meet the need for rapid review and publication of high-quality foundational research and experimental resources in genetics and genomics – an outlet unrestricted by subjective editorial criteria of perceived significance or predicted breadth of interest. Papers published in G3 describe useful, well-executed and lucidly interpreted genetic studies of all kinds. This new peer-reviewed, peer-edited, and fully open access journal meets crucial needs that are not met by current journals in this field.

Founded in 1931, the Genetics Society of America is the professional membership organization for geneticists and science educators. Its nearly 5,000 members work to advance knowledge in the basic mechanisms of inheritance, from the molecular to the population level.

Scannell et al. g3 June 2011 1:11-25; doi:10.1534/g3.111.000273
http://www.g3journal.org/content/1/1/11.full
The Awesome Power of Yeast Evolutionary Genetics: New Genome Sequences and Strain Resources for the Saccharomyces sensu stricto Genus

Tracey DePellegrin Connelly | Newswise Science News
Further information:
http://www.g3journal.org

More articles from Life Sciences:

nachricht Research team creates new possibilities for medicine and materials sciences
22.01.2018 | Humboldt-Universität zu Berlin

nachricht Saarland University bioinformaticians compute gene sequences inherited from each parent
22.01.2018 | Universität des Saarlandes

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Artificial agent designs quantum experiments

On the way to an intelligent laboratory, physicists from Innsbruck and Vienna present an artificial agent that autonomously designs quantum experiments. In initial experiments, the system has independently (re)discovered experimental techniques that are nowadays standard in modern quantum optical laboratories. This shows how machines could play a more creative role in research in the future.

We carry smartphones in our pockets, the streets are dotted with semi-autonomous cars, but in the research laboratory experiments are still being designed by...

Im Focus: Scientists decipher key principle behind reaction of metalloenzymes

So-called pre-distorted states accelerate photochemical reactions too

What enables electrons to be transferred swiftly, for example during photosynthesis? An interdisciplinary team of researchers has worked out the details of how...

Im Focus: The first precise measurement of a single molecule's effective charge

For the first time, scientists have precisely measured the effective electrical charge of a single molecule in solution. This fundamental insight of an SNSF Professor could also pave the way for future medical diagnostics.

Electrical charge is one of the key properties that allows molecules to interact. Life itself depends on this phenomenon: many biological processes involve...

Im Focus: Paradigm shift in Paris: Encouraging an holistic view of laser machining

At the JEC World Composite Show in Paris in March 2018, the Fraunhofer Institute for Laser Technology ILT will be focusing on the latest trends and innovations in laser machining of composites. Among other things, researchers at the booth shared with the Aachen Center for Integrative Lightweight Production (AZL) will demonstrate how lasers can be used for joining, structuring, cutting and drilling composite materials.

No other industry has attracted as much public attention to composite materials as the automotive industry, which along with the aerospace industry is a driver...

Im Focus: Room-temperature multiferroic thin films and their properties

Scientists at Tokyo Institute of Technology (Tokyo Tech) and Tohoku University have developed high-quality GFO epitaxial films and systematically investigated their ferroelectric and ferromagnetic properties. They also demonstrated the room-temperature magnetocapacitance effects of these GFO thin films.

Multiferroic materials show magnetically driven ferroelectricity. They are attracting increasing attention because of their fascinating properties such as...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

10th International Symposium: “Advanced Battery Power – Kraftwerk Batterie” Münster, 10-11 April 2018

08.01.2018 | Event News

See, understand and experience the work of the future

11.12.2017 | Event News

Innovative strategies to tackle parasitic worms

08.12.2017 | Event News

 
Latest News

Thanks for the memory: NIST takes a deep look at memristors

22.01.2018 | Materials Sciences

Radioactivity from oil and gas wastewater persists in Pennsylvania stream sediments

22.01.2018 | Earth Sciences

Saarland University bioinformaticians compute gene sequences inherited from each parent

22.01.2018 | Life Sciences

VideoLinks Wissenschaft & Forschung
Overview of more VideoLinks >>>