Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Scientists first to grow organ in animal from cells created in lab

26.08.2014

Laboratory-grown replacement organs have moved a step closer with the completion of a new study.

Scientists have grown a fully functional organ from transplanted laboratory-created cells in a living animal for the first time.

World's First Working Organ Grown in An Animal from Lab-Created Cells

Scientists have grown a fully functional organ from transplanted laboratory-created cells in a living animal for the first time. They grew a working thymus -- an important organ that supplies the body with immune cells. Left: Specialised thymus cells were created in the lab from a completely different cell type using a technique called reprogramming. Right: The laboratory-created cells were transplanted onto a mouse kidney to form an organised and functional mini-thymus in a living animal.

Credit: MRC Centre for Regenerative Medicine, University of Edinburgh

The researchers have created a thymus - an organ next to the heart that produces immune cells known as T cells that are vital for guarding against disease.

They hope that, with further research, the discovery could lead to new treatments for people with a weakened immune system.

The team from the MRC Centre for Regenerative Medicine at the University of Edinburgh took cells called fibroblasts from a mouse embryo. They turned the fibroblasts into a completely different type of cell called thymus cells, using a technique called reprogramming.

The reprogrammed cells changed shape to look like thymus cells and were also capable of supporting development of T cells in the lab – a specialised function that only thymus cells can perform.

When the researchers mixed reprogrammed cells with other key thymus cell types and transplanted them into a mouse, the cells formed a replacement organ. The new organ had the same structure, complexity and function as a healthy adult thymus.

It is the first time that scientists have made an entire living organ from cells that were created outside of the body by reprogramming.

Doctors have already shown that patients with thymus disorders can be treated with infusions of extra immune cells or transplantation of a thymus organ soon after birth. The problem is that both are limited by a lack of donors and problems matching tissue to the recipient.

With further refinement, the researchers hope that their lab-grown cells could form the basis of a thymus transplant treatment for people with a weakened immune system.

The technique may also offer a way of making patient-matched T cells in the laboratory that could be used in cell therapies.

Such treatments could benefit bone marrow transplant patients, by helping speed up the rate at which they rebuild their immune system after transplant.

The discovery offers hope to babies born with genetic conditions that prevent the thymus from developing properly. Older people could also be helped as the thymus is the first organ to deteriorate with age.

The study is published today in the journal Nature Cell Biology.

Professor Clare Blackburn from the MRC Centre for Regenerative Medicine at the University of Edinburgh, who led the research, said: "Our research represents an important step towards the goal of generating a clinically useful artificial thymus in the lab."

Dr Rob Buckle, Head of Regenerative Medicine at the MRC, said: "This is an exciting study but much more work will be needed before this process can be reproduced in a safe and tightly controlled way suitable for use in humans."

Jen Middleton | Eurek Alert!
Further information:
http://www.ed.ac.uk

Further reports about: MRC Medicine created fibroblasts function grow immune reprogrammed transplant transplanted

More articles from Life Sciences:

nachricht Antimicrobial substances identified in Komodo dragon blood
23.02.2017 | American Chemical Society

nachricht New Mechanisms of Gene Inactivation may prevent Aging and Cancer
23.02.2017 | Leibniz-Institut für Alternsforschung - Fritz-Lipmann-Institut e.V. (FLI)

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

Im Focus: Mimicking nature's cellular architectures via 3-D printing

Research offers new level of control over the structure of 3-D printed materials

Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...

Im Focus: Three Magnetic States for Each Hole

Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".

Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

From rocks in Colorado, evidence of a 'chaotic solar system'

23.02.2017 | Physics and Astronomy

'Quartz' crystals at the Earth's core power its magnetic field

23.02.2017 | Earth Sciences

Antimicrobial substances identified in Komodo dragon blood

23.02.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>